Ditran (original) (raw)
Ditran (JB-329) is an anticholinergic drug mixture, related to the chemical warfare agent 3-Quinuclidinyl benzilate (QNB). Ditran is composed of a mixture of 70% 1-ethyl-2-pyrrolidinylmethyl-alpha- phenylcyclopentylglycolate and 30% 1-ethyl-3-piperidyl-alpha-phenylcyclopentylglycolate. These compounds are structural isomers and have very similar pharmacological properties. The piperidine compound is the more potent of the two and the reason the mixture was used was because of ease of manufacture, however it is also possible to make the piperidine compound in its pure form, so there were ultimately two forms of Ditran used in research, the original 70/30 mix, and "Ditran-B", the pure piperidine compound. Ditran was developed during chemical weapons research in an attempt to produce non-leth
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| dbo:abstract | Ditran (JB-329) is an anticholinergic drug mixture, related to the chemical warfare agent 3-Quinuclidinyl benzilate (QNB). Ditran is composed of a mixture of 70% 1-ethyl-2-pyrrolidinylmethyl-alpha- phenylcyclopentylglycolate and 30% 1-ethyl-3-piperidyl-alpha-phenylcyclopentylglycolate. These compounds are structural isomers and have very similar pharmacological properties. The piperidine compound is the more potent of the two and the reason the mixture was used was because of ease of manufacture, however it is also possible to make the piperidine compound in its pure form, so there were ultimately two forms of Ditran used in research, the original 70/30 mix, and "Ditran-B", the pure piperidine compound. Ditran was developed during chemical weapons research in an attempt to produce non-lethal incapacitating agents, similar to QNB itself. The ditran mixture is more potent as an anticholinergic than the piperidyl benzilate drugs such as N-methyl-3-piperidyl benzilate, but is less potent than QNB. There has been a modest amount of scientific research using this mixture, but most modern research using these kinds of anticholinergic drugs uses N-methyl-3-piperidyl benzilate due to its wider availability. (en) Ditran – potencjalny psychotoksyczny bojowy środek trujący o silnym działaniu halucynogennym. Jest mieszaniną dwóch izomerycznych związków chemicznych z grupy fenyloglikolanów: * N-etylo-3-pirolidylometylofenylocyklopentyloglikolanu (70%; Ditran I) * N-etylo-3-piperydylofenylocyklopentyloglikolanu (30%; Ditran II) Ditran powoduje trwające 20-24 godzin psychozy o objawach przypominających choroby psychiczne. Dawki doustne rzędu 5–15 mg powodują rozszerzenie źrenic, osłabienie mięśni, suchość w jamie ustnej i podwyższenie tętna. Po około godzinie stopniowo pojawiają się zaburzenia mowy, utrudniona koncentracja i orientacja, następnie silne halucynacje (wzrokowe, słuchowe i dotykowe), całkowicie wyłączające człowieka z otaczającej rzeczywistości. W niektórych przypadkach powoduje brak reakcji na bodźce zewnętrzne. Identyfikacja: * numer CAS: 8015-54-1 (pl) |
| dbo:casNumber | 8015-54-1 |
| dbo:chEMBL | 126644 |
| dbo:fdaUniiCode | US46XLX8YH |
| dbo:pubchem | 111040 |
| dbo:thumbnail | wiki-commons:Special:FilePath/Ditran.svg?width=300 |
| dbo:wikiPageID | 18549998 (xsd:integer) |
| dbo:wikiPageLength | 4598 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1085968535 (xsd:integer) |
| dbo:wikiPageWikiLink | dbc:Acetate_esters dbc:Piperidines dbc:Pyrrolidines dbc:Tertiary_alcohols dbr:Structural_isomer dbr:N-Ethyl-3-piperidyl_benzilate dbr:N-Methyl-3-piperidyl_benzilate dbr:Anticholinergic dbr:3-Quinuclidinyl_benzilate dbc:Deliriants dbc:Muscarinic_antagonists dbr:EA-3167 dbc:Phenylcyclopentylglycolate_esters dbr:Chemical_weapons |
| dbp:c | 20 (xsd:integer) |
| dbp:casNumber | 8015 (xsd:integer) |
| dbp:chembl | 126644 (xsd:integer) |
| dbp:h | 29 (xsd:integer) |
| dbp:iupacName | mixture of methyl 2-cyclopentyl-2-hydroxy-2-phenylacetate and -2-cyclopentyl-2-hydroxy-2-phenylacetate (en) |
| dbp:n | 1 (xsd:integer) |
| dbp:o | 3 (xsd:integer) |
| dbp:pubchem | 111040 (xsd:integer) |
| dbp:unii | US46XLX8YH (en) |
| dbp:verifiedfields | changed (en) |
| dbp:verifiedrevid | 399960637 (xsd:integer) |
| dbp:watchedfields | changed (en) |
| dbp:width | 300 (xsd:integer) |
| dbp:wikiPageUsesTemplate | dbt:Commonscat-inline dbt:Drugbox dbt:Hallucinogens dbt:Reflist dbt:Short_description dbt:Cascite dbt:Drugbankcite dbt:Ebicite dbt:Fdacite dbt:Muscarinic_acetylcholine_receptor_modulators dbt:Hallucinogen-stub |
| dcterms:subject | dbc:Acetate_esters dbc:Piperidines dbc:Pyrrolidines dbc:Tertiary_alcohols dbc:Deliriants dbc:Muscarinic_antagonists dbc:Phenylcyclopentylglycolate_esters |
| gold:hypernym | dbr:Mixture |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatAnticholinergics yago:Agent109190918 yago:Agent114778436 yago:Anticholinergic102717901 yago:CausalAgent100007347 yago:Drug103247620 yago:Matter100020827 yago:Medicine103740161 yago:PhysicalEntity100001930 yago:PsychoactiveDrug104017137 yago:WikicatIncapacitatingAgents dbo:Drug yago:Substance100020090 yago:WikicatPsychoactiveDrugs umbel-rc:DrugProduct |
| rdfs:comment | Ditran (JB-329) is an anticholinergic drug mixture, related to the chemical warfare agent 3-Quinuclidinyl benzilate (QNB). Ditran is composed of a mixture of 70% 1-ethyl-2-pyrrolidinylmethyl-alpha- phenylcyclopentylglycolate and 30% 1-ethyl-3-piperidyl-alpha-phenylcyclopentylglycolate. These compounds are structural isomers and have very similar pharmacological properties. The piperidine compound is the more potent of the two and the reason the mixture was used was because of ease of manufacture, however it is also possible to make the piperidine compound in its pure form, so there were ultimately two forms of Ditran used in research, the original 70/30 mix, and "Ditran-B", the pure piperidine compound. Ditran was developed during chemical weapons research in an attempt to produce non-leth (en) Ditran – potencjalny psychotoksyczny bojowy środek trujący o silnym działaniu halucynogennym. Jest mieszaniną dwóch izomerycznych związków chemicznych z grupy fenyloglikolanów: * N-etylo-3-pirolidylometylofenylocyklopentyloglikolanu (70%; Ditran I) * N-etylo-3-piperydylofenylocyklopentyloglikolanu (30%; Ditran II) Identyfikacja: * numer CAS: 8015-54-1 (pl) |
| rdfs:label | Ditran (en) Ditran (pl) |
| owl:sameAs | freebase:Ditran yago-res:Ditran wikidata:Ditran dbpedia-pl:Ditran dbpedia-sh:Ditran dbpedia-sr:Ditran https://global.dbpedia.org/id/4jBGm |
| prov:wasDerivedFrom | wikipedia-en:Ditran?oldid=1085968535&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Ditran.svg |
| foaf:isPrimaryTopicOf | wikipedia-en:Ditran |
| is dbo:wikiPageWikiLink of | dbr:N-Ethyl-3-piperidyl_benzilate dbr:N-Methyl-3-piperidyl_benzilate dbr:Deliriant dbr:CAR-226,086 dbr:CAR-302,196 dbr:EA-3167 dbr:EA-3443 dbr:EA-3580 dbr:EA-3834 dbr:Holmesburg_Prison dbr:C20H29NO3 dbr:CAR-301,060 dbr:Piperidine |
| is foaf:primaryTopic of | wikipedia-en:Ditran |
