ERG5 (original) (raw)
ERG5 or Sterol 22-desaturase is a cytochrome P450 enzyme in the ergosterol biosynthesis pathway of fungi Saccharomyces cerevisiae (Baker's yeast, a model organism), with the CYP Symbol CYP61A1. CYP61A1 is one of only three P450 enzyme found in baker's yeast, the other two are CYP51F1 and CYP56A1. The ortholog in Schizosaccharomyces pombe (fission yeast, the second sequenced model fungi), was named CYP61A3 for historical reasons, and is only one of two P450 enzyme found with CYP51F1. ERG5 catalyzes the C22-C23 double bond formation on the sterol side chain of ergostatrienol to convert it into , then the C24 double bond of ergostatetrenol will be hydrogenation reduced into ergosterol by ERG4.
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| dbo:abstract | ERG5 or Sterol 22-desaturase is a cytochrome P450 enzyme in the ergosterol biosynthesis pathway of fungi Saccharomyces cerevisiae (Baker's yeast, a model organism), with the CYP Symbol CYP61A1. CYP61A1 is one of only three P450 enzyme found in baker's yeast, the other two are CYP51F1 and CYP56A1. The ortholog in Schizosaccharomyces pombe (fission yeast, the second sequenced model fungi), was named CYP61A3 for historical reasons, and is only one of two P450 enzyme found with CYP51F1. ERG5 catalyzes the C22-C23 double bond formation on the sterol side chain of ergostatrienol to convert it into , then the C24 double bond of ergostatetrenol will be hydrogenation reduced into ergosterol by ERG4. (en) ERG5 或固醇-22-去饱和酶（英語：Sterol 22-desaturase）是真菌釀酒酵母（Saccharomyces cerevisiae）基因组中的一个涉及麦角固醇生物合成的细胞色素P450酶，其CYP编号为CYP61A1，是釀酒酵母三种细胞色素P450基因之一，另外两种是CYP51F1和CYP56A1。ERG5可催化类固醇C17侧链上C22-C23位置脱氢形成双键，如麦角固醇生物合成中的5-脱氢表甾醇（也称为“麦角三烯醇”）转化为，之后麦角四烯醇的C24双键会被酶ERG4加氢还原为麦角固醇。 (zh) |
| dbo:wikiPageID | 64012174 (xsd:integer) |
| dbo:wikiPageLength | 4902 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1093336995 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Cytochrome_P450 dbr:ERG11 dbr:ERG4 dbr:Saccharomyces_cerevisiae dbr:List_of_sequenced_eukaryotic_genomes dbc:Cytochrome_P450 dbc:EC_1.14.19 dbr:Enzyme dbr:Fungi dbr:Botrytis_cinerea dbr:Schizosaccharomyces_pombe dbr:DIT2 dbr:Ergosterol dbr:Hydrogenation dbc:Saccharomyces_cerevisiae_genes dbr:Model_organism dbr:Candida_albicans dbr:Neurospora_crassa dbr:Ergostatrienol dbr:Ergostatetraenol |
| dbp:altsymbols | CYP61A1 (en) |
| dbp:chromosome | XIII (en) |
| dbp:ecnumber | 1.140000 (xsd:double) |
| dbp:entrezchromosome | NC_001145.3 (en) |
| dbp:entrezgene | 855029 (xsd:integer) |
| dbp:genlocEnd | 302485 (xsd:integer) |
| dbp:genlocStart | 300869 (xsd:integer) |
| dbp:homologene | 20212 (xsd:integer) |
| dbp:name | Sterol 22-desaturase (en) |
| dbp:organism | Saccharomyces cerevisiae S288c (en) |
| dbp:refseqmrna | NM_001182511.1 (en) |
| dbp:refseqprotein | NP_013728.1 (en) |
| dbp:symbol | ERG5 (en) |
| dbp:taxid | 559292 (xsd:integer) |
| dbp:uniprot | P54781 (en) |
| dbp:wikiPageUsesTemplate | dbt:UniProt dbt:Cytochrome_P450 dbt:Enzyme-stub dbt:Infobox_nonhuman_protein dbt:Reflist |
| dct:subject | dbc:Cytochrome_P450 dbc:EC_1.14.19 dbc:Saccharomyces_cerevisiae_genes |
| rdfs:comment | ERG5 or Sterol 22-desaturase is a cytochrome P450 enzyme in the ergosterol biosynthesis pathway of fungi Saccharomyces cerevisiae (Baker's yeast, a model organism), with the CYP Symbol CYP61A1. CYP61A1 is one of only three P450 enzyme found in baker's yeast, the other two are CYP51F1 and CYP56A1. The ortholog in Schizosaccharomyces pombe (fission yeast, the second sequenced model fungi), was named CYP61A3 for historical reasons, and is only one of two P450 enzyme found with CYP51F1. ERG5 catalyzes the C22-C23 double bond formation on the sterol side chain of ergostatrienol to convert it into , then the C24 double bond of ergostatetrenol will be hydrogenation reduced into ergosterol by ERG4. (en) ERG5 或固醇-22-去饱和酶（英語：Sterol 22-desaturase）是真菌釀酒酵母（Saccharomyces cerevisiae）基因组中的一个涉及麦角固醇生物合成的细胞色素P450酶，其CYP编号为CYP61A1，是釀酒酵母三种细胞色素P450基因之一，另外两种是CYP51F1和CYP56A1。ERG5可催化类固醇C17侧链上C22-C23位置脱氢形成双键，如麦角固醇生物合成中的5-脱氢表甾醇（也称为“麦角三烯醇”）转化为，之后麦角四烯醇的C24双键会被酶ERG4加氢还原为麦角固醇。 (zh) |
| rdfs:label | ERG5 (en) ERG5 (zh) |
| owl:sameAs | wikidata:ERG5 dbpedia-zh:ERG5 https://global.dbpedia.org/id/2Zbz3 |
| prov:wasDerivedFrom | wikipedia-en:ERG5?oldid=1093336995&ns=0 |
| foaf:isPrimaryTopicOf | wikipedia-en:ERG5 |
| is dbo:wikiPageRedirects of | dbr:CYP61 |
| is dbo:wikiPageWikiLink of | dbr:CYP56A1 dbr:CYP710_family dbr:CYP61 |
| is foaf:primaryTopic of | wikipedia-en:ERG5 |