| dbo:abstract |
Eikosanoidní receptor je receptor zpravidla spřažený s G proteinem, který se váže na eikosanoidní signální molekuly. Eikosanoidy jsou rychle metabolizovány na neaktivní produkty a působí proto krátce a ilokálně.. Buňky po stimulaci metabolizují arachidonovou kyselinu na eikosanoid, který se pak váže na koreceptory a to na svou mateřské buňku (autokrinní signalizace) nebo na blízké buňky (parakrinní signálizace) a tím se vyvola funkční odpověď v rámci omezené oblasti tkáně, např. zánětlivou reakci na invazi patogenu. V některých případech však syntetizováný eikosanoid se šíří krví a působí jako pseudo hormonální messenger pro spuštění systémové a koordinované reakce tkáně, např. prostaglandin (PG) E2 cestuje do hypothalamu a vyvolá febrilní reakce (viz Horečka#uvolňování PGE2). Příkladem receptoru nespřaženého s G proteinem je PPAR-γ nukleární receptor. (cs) Most of the eicosanoid receptors are integral membrane protein G protein-coupled receptors (GPCRs) that bind and respond to eicosanoid signaling molecules. Eicosanoids are rapidly metabolized to inactive products and therefore are short-lived. Accordingly, the eicosanoid-receptor interaction is typically limited to a local interaction: cells, upon stimulation, metabolize arachidonic acid to an eicosanoid which then binds cognate receptors on either its parent cell (acting as an Autocrine signalling molecule) or on nearby cells (acting as a Paracrine signalling molecule) to trigger functional responses within a restricted tissue area, e.g. an inflammatory response to an invading pathogen. In some cases, however, the synthesized eicosanoid travels through the blood (acting as a hormone-like messenger) to trigger systemic or coordinated tissue responses, e.g. prostaglandin (PG) E2 released locally travels to the hypothalamus to trigger a febrile reaction (see Fever § PGE2 release). An example of a non-GPCR receptor that binds many eicosanoids is the PPAR-γ nuclear receptor. The following is a list of human eicosanoid GPCRs grouped according to the type of eicosanoid ligand that each binds: (en) Um receptor eicosanoide(pt-BR) ou recetor eicosanoide(pt-PT?) é uma proteína integral de membrana que deteta a presença de moléculas de sinalização chamadas eicosanoides. A maioria, porém não todos, são receptores acoplados à proteína G (GPCRs). Um exemplo de um receptor não-GPCR, que se liga eicosanóides é PPAR-γ. (pt) |
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http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward%3FobjectId=223 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward%3FobjectId=267; http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward%3FobjectId=268). http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward%3FobjectId=270). http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward%3FobjectId=271). http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward%3FobjectId=338). http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward%3FobjectId=339&familyId=58&familyType=GPCR). http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward%3FobjectId=341). http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward%3FobjectId=342). http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward%3FobjectId=343). http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward%3FobjectId=344). http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward%3FobjectId=345). http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward%3FobjectId=346&familyId=58&familyType=GPCR). http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward%3FobjectId=79). http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward%3FobjectId=88) http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward%3FobjectId=88). http://www.iuphar-db.org/GPCR/ChapterMenuForward%3FchapterID=1289 http://www.iuphar-db.org/GPCR/ChapterMenuForward%3FchapterID=1297 |
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| rdfs:comment |
Um receptor eicosanoide(pt-BR) ou recetor eicosanoide(pt-PT?) é uma proteína integral de membrana que deteta a presença de moléculas de sinalização chamadas eicosanoides. A maioria, porém não todos, são receptores acoplados à proteína G (GPCRs). Um exemplo de um receptor não-GPCR, que se liga eicosanóides é PPAR-γ. (pt) Eikosanoidní receptor je receptor zpravidla spřažený s G proteinem, který se váže na eikosanoidní signální molekuly. Eikosanoidy jsou rychle metabolizovány na neaktivní produkty a působí proto krátce a ilokálně.. Buňky po stimulaci metabolizují arachidonovou kyselinu na eikosanoid, který se pak váže na koreceptory a to na svou mateřské buňku (autokrinní signalizace) nebo na blízké buňky (parakrinní signálizace) a tím se vyvola funkční odpověď v rámci omezené oblasti tkáně, např. zánětlivou reakci na invazi patogenu. V některých případech však syntetizováný eikosanoid se šíří krví a působí jako pseudo hormonální messenger pro spuštění systémové a koordinované reakce tkáně, např. prostaglandin (PG) E2 cestuje do hypothalamu a vyvolá febrilní reakce (viz Horečka#uvolňování PGE2). Příkladem re (cs) Most of the eicosanoid receptors are integral membrane protein G protein-coupled receptors (GPCRs) that bind and respond to eicosanoid signaling molecules. Eicosanoids are rapidly metabolized to inactive products and therefore are short-lived. Accordingly, the eicosanoid-receptor interaction is typically limited to a local interaction: cells, upon stimulation, metabolize arachidonic acid to an eicosanoid which then binds cognate receptors on either its parent cell (acting as an Autocrine signalling molecule) or on nearby cells (acting as a Paracrine signalling molecule) to trigger functional responses within a restricted tissue area, e.g. an inflammatory response to an invading pathogen. In some cases, however, the synthesized eicosanoid travels through the blood (acting as a hormone-like (en) |
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Eikosanoidní receptor (cs) Eicosanoid receptor (en) Receptor eicosanoide (pt) |
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