Endomorphin-2 (original) (raw)
Endomorphin-2 (EM-2) is an endogenous opioid peptide and one of the two endomorphins. It has the amino acid sequence Tyr-Pro-Phe-Phe-NH2. It is a high affinity, highly selective agonist of the μ-opioid receptor, and along with endomorphin-1 (EM-1), has been proposed to be the actual endogenous ligand of this receptor (that is, rather than the endorphins). Like EM-1, EM-2 produces analgesia in animals, but whereas EM-1 is more prevalent in the brain, EM-2 is more prevalent in the spinal cord. In addition, the action of EM-2 differs from that of EM-1 somewhat, because EM-2 additionally induces the release of dynorphin A and [Met]enkephalin in the spinal cord and brain by an unknown mechanism, which in turn go on to activate the κ- and δ-opioid receptors, respectively, and a portion of the an
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| dbo:abstract | Endomorphin-2 (EM-2) is an endogenous opioid peptide and one of the two endomorphins. It has the amino acid sequence Tyr-Pro-Phe-Phe-NH2. It is a high affinity, highly selective agonist of the μ-opioid receptor, and along with endomorphin-1 (EM-1), has been proposed to be the actual endogenous ligand of this receptor (that is, rather than the endorphins). Like EM-1, EM-2 produces analgesia in animals, but whereas EM-1 is more prevalent in the brain, EM-2 is more prevalent in the spinal cord. In addition, the action of EM-2 differs from that of EM-1 somewhat, because EM-2 additionally induces the release of dynorphin A and [Met]enkephalin in the spinal cord and brain by an unknown mechanism, which in turn go on to activate the κ- and δ-opioid receptors, respectively, and a portion of the analgesic effects of EM-2 is dependent on this action. Moreover, while EM-1 produces conditioned place preference, a measure of drug reward, EM-2 produces conditioned place aversion, an effect which is dynorphin A-dependent. Similarly to the case of EM-1, the gene encoding for EM-2 has not yet been identified. (en) |
| dbo:iupacName | (L)-Tyrosyl-(L)-prolyl-(L)-phenylalanyl-(L)-phenylalaninamide (en) |
| dbo:thumbnail | wiki-commons:Special:FilePath/Endomorphin_2.svg?width=300 |
| dbo:wikiPageID | 44927916 (xsd:integer) |
| dbo:wikiPageLength | 5134 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1051003115 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Ligand_(biochemistry) dbr:Δ-opioid_receptor dbc:Mu-opioid_receptor_agonists dbr:Endomorphin dbr:Endorphin dbr:Gene dbr:Brain dbr:Conditioned_place_preference dbr:Opioid_peptide dbr:Agonist dbr:Analgesia dbr:Dynorphin_A dbr:Endogenous dbr:Μ-opioid_receptor dbc:Neuropeptides dbr:Affinity_(pharmacology) dbr:Met-enkephalin dbr:Mechanism_of_action dbr:Κ-opioid_receptor dbr:Spinal_cord dbr:Drug_reward dbr:Amino_acid_sequence dbr:Conditioned_place_aversion dbr:Β-Endorphin |
| dbp:imagefile | Endomorphin 2.svg (en) |
| dbp:imagesize | 250 (xsd:integer) |
| dbp:iupacname | (L)-Tyrosyl-(L)-prolyl-(L)-phenylalanyl-(L)-phenylalaninamide (en) |
| dbp:wikiPageUsesTemplate | dbt:Chembox dbt:Chembox_Hazards dbt:Chembox_Identifiers dbt:Chembox_Properties dbt:Opioidergics dbt:Reflist dbt:Cascite dbt:Fdacite dbt:Neuropeptides |
| dct:subject | dbc:Mu-opioid_receptor_agonists dbc:Neuropeptides |
| gold:hypernym | dbr:Peptide |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q11173 dbo:ChemicalCompound |
| rdfs:comment | Endomorphin-2 (EM-2) is an endogenous opioid peptide and one of the two endomorphins. It has the amino acid sequence Tyr-Pro-Phe-Phe-NH2. It is a high affinity, highly selective agonist of the μ-opioid receptor, and along with endomorphin-1 (EM-1), has been proposed to be the actual endogenous ligand of this receptor (that is, rather than the endorphins). Like EM-1, EM-2 produces analgesia in animals, but whereas EM-1 is more prevalent in the brain, EM-2 is more prevalent in the spinal cord. In addition, the action of EM-2 differs from that of EM-1 somewhat, because EM-2 additionally induces the release of dynorphin A and [Met]enkephalin in the spinal cord and brain by an unknown mechanism, which in turn go on to activate the κ- and δ-opioid receptors, respectively, and a portion of the an (en) |
| rdfs:label | Endomorphin-2 (en) |
| owl:sameAs | freebase:Endomorphin-2 wikidata:Endomorphin-2 https://global.dbpedia.org/id/shC7 |
| prov:wasDerivedFrom | wikipedia-en:Endomorphin-2?oldid=1051003115&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Endomorphin_2.svg |
| foaf:isPrimaryTopicOf | wikipedia-en:Endomorphin-2 |
| is dbo:wikiPageRedirects of | dbr:Endomorphin_2 |
| is dbo:wikiPageWikiLink of | dbr:List_of_opioids dbr:Endomorphin-1 dbr:Opioid_peptide dbr:Endomorphin_2 |
| is foaf:primaryTopic of | wikipedia-en:Endomorphin-2 |
