Eosinophil peroxidase (original) (raw)
La perossidasi eosinofila o EPO (dall'inglese eosinophil peroxidase) è un enzima perossidasi codificato negli esseri umani dal gene EPX.È un eterodimero 71-77 kD composto da una catena più pesante glicosilata e una più leggera non glicosilata.
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| dbo:abstract | Eosinophil peroxidase is an enzyme found within the eosinophil granulocytes, innate immune cells of humans and mammals. This oxidoreductase protein is encoded by the gene EPX, expressed within these myeloid cells. EPO shares many similarities with its orthologous peroxidases, myeloperoxidase (MPO), lactoperoxidase (LPO), and thyroid peroxidase (TPO). The protein is concentrated in secretory granules within eosinophils. Eosinophil peroxidase is a heme peroxidase, its activities including the oxidation of halide ions to bacteriocidal reactive oxygen species, the cationic disruption of bacterial cell walls, and the post-translational modification of protein amino acid residues. The major function of eosinophil peroxidase is to catalyze the formation of from hydrogen peroxide and halide ions in solution. For example: H2O2 + Br− → HOBr + H2O Hypohalous acids formed from halides or pseudohalides are potent oxidizing agents. However, the role of eosinophilic peroxidase seems to be to generate hyphalous acids largely from bromide and iodide rather than chloride, since the former are favored greatly over the latter. The enzyme myeloperoxidase is responsible for formation of most of the hypochlorous acid in the body, and eosinophil peroxidase is responsible for reactions involving bromide and iodide. (en) Une peroxydase d'éosinophile, presque toujours écrite éosinophile peroxydase (EPO), est une oxydoréductase qui catalyse une réaction chimique du type : H2O2 + Br− → BrO− + H2O. Cette enzyme est présente dans les granulocytes éosinophiles, cellules du système immunitaire inné des mammifères. Chez l'homme, elle est codée par le gène EPX, situé sur le chromosome 17, et est exprimée dans les myélocytes. Elle partage de nombreuses similitudes avec les peroxydases orthologues, comme la myéloperoxydase (MPO), la lactoperoxydase (LPO) et la thyroperoxydase (TPO). Cette protéine est concentrée dans les granules de sécrétion au sein des éosinophiles. Il s'agit d'une peroxydase héminique susceptible d'oxyder des halogénures afin de produire des dérivés réactifs de l'oxygène bactéricides, de favoriser la destruction cationique de la paroi bactérienne, et de catalyser des modifications post-traductionnelles de résidus d'acides aminés. Peroxydase héminique (fr) La perossidasi eosinofila o EPO (dall'inglese eosinophil peroxidase) è un enzima perossidasi codificato negli esseri umani dal gene EPX.È un eterodimero 71-77 kD composto da una catena più pesante glicosilata e una più leggera non glicosilata. (it) EPX (англ. Eosinophil peroxidase) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 17-ї хромосоми. Довжина поліпептидного ланцюга білка становить 715 амінокислот, а молекулярна маса — 81 040. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Кодований геном білок за функціями належить до оксидоредуктаз, . Задіяний у такому біологічному процесі, як перекис водню. Білок має сайт для зв'язування з іонами металів, іоном кальцію, іоном заліза, гемом. (uk) |
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| rdfs:comment | La perossidasi eosinofila o EPO (dall'inglese eosinophil peroxidase) è un enzima perossidasi codificato negli esseri umani dal gene EPX.È un eterodimero 71-77 kD composto da una catena più pesante glicosilata e una più leggera non glicosilata. (it) Eosinophil peroxidase is an enzyme found within the eosinophil granulocytes, innate immune cells of humans and mammals. This oxidoreductase protein is encoded by the gene EPX, expressed within these myeloid cells. EPO shares many similarities with its orthologous peroxidases, myeloperoxidase (MPO), lactoperoxidase (LPO), and thyroid peroxidase (TPO). The protein is concentrated in secretory granules within eosinophils. Eosinophil peroxidase is a heme peroxidase, its activities including the oxidation of halide ions to bacteriocidal reactive oxygen species, the cationic disruption of bacterial cell walls, and the post-translational modification of protein amino acid residues. (en) Une peroxydase d'éosinophile, presque toujours écrite éosinophile peroxydase (EPO), est une oxydoréductase qui catalyse une réaction chimique du type : H2O2 + Br− → BrO− + H2O. Cette enzyme est présente dans les granulocytes éosinophiles, cellules du système immunitaire inné des mammifères. Chez l'homme, elle est codée par le gène EPX, situé sur le chromosome 17, et est exprimée dans les myélocytes. Elle partage de nombreuses similitudes avec les peroxydases orthologues, comme la myéloperoxydase (MPO), la lactoperoxydase (LPO) et la thyroperoxydase (TPO). Peroxydase héminique (fr) EPX (англ. Eosinophil peroxidase) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 17-ї хромосоми. Довжина поліпептидного ланцюга білка становить 715 амінокислот, а молекулярна маса — 81 040. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин (uk) |
| rdfs:label | Eosinophil peroxidase (en) Éosinophile peroxydase (fr) Perossidasi eosinofila (it) EPX (uk) |
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