Eoxin A4 (original) (raw)
Eoxin A4, also known as 14,15-leukotriene A4, is an eoxin. Cells make eoxins by metabolizing arachidonic acid with a 15-lipoxygenase enzyme to form 15(S)-hydroperoxyeicosapentaenoic acid (i.e. 15(S)-HpETE). This product is then converted serially to eoxin A4 (i.e. EXA4), EXC4, EXD4, and EXE4 by LTC4 synthase, an unidentified gamma-glutamyltransferase, and an unidentified dipeptidase, respectively, in a pathway which appears similar if not identical to the pathway which forms leukotreines, i.e. LTA4, LTC4, LTD4, and LTE4. This pathway is schematically shown as follows:
| Property | Value |
|---|---|
| dbo:abstract | Eoxin A4, also known as 14,15-leukotriene A4, is an eoxin. Cells make eoxins by metabolizing arachidonic acid with a 15-lipoxygenase enzyme to form 15(S)-hydroperoxyeicosapentaenoic acid (i.e. 15(S)-HpETE). This product is then converted serially to eoxin A4 (i.e. EXA4), EXC4, EXD4, and EXE4 by LTC4 synthase, an unidentified gamma-glutamyltransferase, and an unidentified dipeptidase, respectively, in a pathway which appears similar if not identical to the pathway which forms leukotreines, i.e. LTA4, LTC4, LTD4, and LTE4. This pathway is schematically shown as follows: Arachidonic acid + O2 → 15(S)-HpETE → EXA4 → EXC4 → EXD4 → EXE4 EXA4 is viewed as an intracellular-bound, short-lived intermediate which is rapidly metabolized to the down-stream eoxins. The eoxins down stream of EXA4 are secreted from their parent cells and, it is proposed but not yet proven, serve to regulate allergic responses and the development of certain cancers (see Eoxins). (en) |
| dbo:alternativeName | EXa4; 14,15-LTA4 (en) |
| dbo:iupacName | (5Z,8Z,10E,12E)-13-[(2S,3S)-3-Pentyloxiran-2-yl]trideca-5,8,10,12-tetraenoic acid (en) |
| dbo:thumbnail | wiki-commons:Special:FilePath/Eoxin_A4.svg?width=300 |
| dbo:wikiPageID | 44965596 (xsd:integer) |
| dbo:wikiPageLength | 3386 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1119001352 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Eoxin dbr:15-Hydroxyeicosatetraenoic_acid dbr:15-lipoxygenase dbc:Eicosanoids dbr:Eoxins dbr:Leukotriene_A4 dbr:Gamma-glutamyltransferase dbr:EXA4 dbr:EXD4 dbr:EXE4 dbr:Dipeptidase dbr:LTD4 dbr:LTA4 dbr:LTC4 dbr:LTC4_synthase dbr:LTE4 |
| dbp:imagefile | Eoxin A4.svg (en) |
| dbp:imagesize | 200 (xsd:integer) |
| dbp:othernames | EXa4; 14,15-LTA4 (en) |
| dbp:pin | -13 (xsd:integer) |
| dbp:wikiPageUsesTemplate | dbt:Biochemistry-stub dbt:Center dbt:Chembox dbt:Chembox_Hazards dbt:Chembox_Identifiers dbt:Chembox_Properties dbt:Leukotrienes dbt:Cascite |
| dcterms:subject | dbc:Eicosanoids |
| gold:hypernym | dbr:Synthase |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q11173 dbo:ChemicalCompound |
| rdfs:comment | Eoxin A4, also known as 14,15-leukotriene A4, is an eoxin. Cells make eoxins by metabolizing arachidonic acid with a 15-lipoxygenase enzyme to form 15(S)-hydroperoxyeicosapentaenoic acid (i.e. 15(S)-HpETE). This product is then converted serially to eoxin A4 (i.e. EXA4), EXC4, EXD4, and EXE4 by LTC4 synthase, an unidentified gamma-glutamyltransferase, and an unidentified dipeptidase, respectively, in a pathway which appears similar if not identical to the pathway which forms leukotreines, i.e. LTA4, LTC4, LTD4, and LTE4. This pathway is schematically shown as follows: (en) |
| rdfs:label | Eoxin A4 (en) |
| owl:sameAs | freebase:Eoxin A4 wikidata:Eoxin A4 https://global.dbpedia.org/id/sQGT |
| prov:wasDerivedFrom | wikipedia-en:Eoxin_A4?oldid=1119001352&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Eoxin_A4.svg |
| foaf:isPrimaryTopicOf | wikipedia-en:Eoxin_A4 |
| is dbo:wikiPageRedirects of | dbr:EXA4 |
| is dbo:wikiPageWikiLink of | dbr:Eoxin dbr:C20H30O3 dbr:15-Hydroxyeicosatetraenoic_acid dbr:EXA4 |
| is foaf:primaryTopic of | wikipedia-en:Eoxin_A4 |
