| dbo:abstract |
Epstein–Barr virus latent membrane protein 1 (LMP1) is an Epstein–Barr virus (EBV) protein that regulates its own expression and the expression of human genes. It has a molecular weight of approximately 63 kDa, and its expression induces many of the changes associated with EBV infections and activation of primary B cells. LMP1 is the best-documented oncoprotein of the EBV latent gene products, as it is expressed in most EBV-related human cancers such as the various malignant Epstein-Barr virus-associated lymphoproliferative diseases. The structure of LMP1 consists of a short cytoplasmic terminal tail, six trans-membrane domains, and a long cytoplasmic C-terminus, which contains three activating domains: CTARt, CTAR2, and CTAR3. Each CTAR domain contains an amino acid sequence that serves as a recognition site for cellular adaptors to bind and trigger a series of signal transduction pathways that can lead to a change in gene expression. LMP-1 is a functional homologue of tumor necrosis factor and mediates signaling through the nuclear factor-κB pathway, mimicking CD40 receptor signaling. It is often found in the malignant Reed–Sternberg cells of Hodgkin lymphoma, the malignant B cells of EBV-associated B cell lymphatic cancers, and the malignant NK cells of NK/T cell lymphatic cancers. (en) EBV proteína latente de la membrana 1 (LMP-1) es una proteína viral asociada con el virus de Epstein-Barr. LMP-1 es un lapso de seis proteínas transmembranales que es también esencial para la transformación del crecimiento mediado por VEB. LMP-1 media la señalización a través del factor de necrosis tumoral-alfa/. Se encuentra a menudo en las células Reed-Sternberg. (es) |
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dbt:Reflist dbt:Viral_proteins |
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dbc:Viral_structural_proteins dbc:Epstein–Barr_virus |
| gold:hypernym |
dbr:Protein |
| rdf:type |
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| rdfs:comment |
EBV proteína latente de la membrana 1 (LMP-1) es una proteína viral asociada con el virus de Epstein-Barr. LMP-1 es un lapso de seis proteínas transmembranales que es también esencial para la transformación del crecimiento mediado por VEB. LMP-1 media la señalización a través del factor de necrosis tumoral-alfa/. Se encuentra a menudo en las células Reed-Sternberg. (es) Epstein–Barr virus latent membrane protein 1 (LMP1) is an Epstein–Barr virus (EBV) protein that regulates its own expression and the expression of human genes. It has a molecular weight of approximately 63 kDa, and its expression induces many of the changes associated with EBV infections and activation of primary B cells. LMP1 is the best-documented oncoprotein of the EBV latent gene products, as it is expressed in most EBV-related human cancers such as the various malignant Epstein-Barr virus-associated lymphoproliferative diseases. (en) |
| rdfs:label |
Proteína latente de la membrana 1 del virus Epstein–Barr (es) Epstein–Barr virus latent membrane protein 1 (en) |
| owl:sameAs |
freebase:Epstein–Barr virus latent membrane protein 1 wikidata:Epstein–Barr virus latent membrane protein 1 dbpedia-es:Epstein–Barr virus latent membrane protein 1 https://global.dbpedia.org/id/4id1M |
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