Excisionase (original) (raw)
In molecular biology, excisionase is a bacteriophage protein encoded by the Xis gene. It is involved in excisive recombination by regulating the assembly of the excisive intasome and by inhibiting viral integration. It adopts an unusual winged-helix structure in which two alpha helices are packed against two extended strands. Also present in the structure is a two-stranded anti-parallel beta-sheet, whose strands are connected by a four-residue wing. During interaction with DNA, helix alpha2 is thought to insert into the major groove, while the wing contacts the adjacent minor groove or phosphodiester backbone. The C-terminal region of excisionase is involved in interaction with phage-encoded integrase (Int), and a putative C-terminal alpha helix may fold upon interaction with Int and/or DN
| Property | Value |
|---|---|
| dbo:abstract | In molecular biology, excisionase is a bacteriophage protein encoded by the Xis gene. It is involved in excisive recombination by regulating the assembly of the excisive intasome and by inhibiting viral integration. It adopts an unusual winged-helix structure in which two alpha helices are packed against two extended strands. Also present in the structure is a two-stranded anti-parallel beta-sheet, whose strands are connected by a four-residue wing. During interaction with DNA, helix alpha2 is thought to insert into the major groove, while the wing contacts the adjacent minor groove or phosphodiester backbone. The C-terminal region of excisionase is involved in interaction with phage-encoded integrase (Int), and a putative C-terminal alpha helix may fold upon interaction with Int and/or DNA. (en) |
| dbo:symbol | Exc |
| dbo:thumbnail | wiki-commons:Special:FilePath/PDB_2og0_EBI.jpg?width=300 |
| dbo:wikiPageID | 32713971 (xsd:integer) |
| dbo:wikiPageLength | 1793 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 995775470 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:DNA dbr:Integrase dbr:Genetic_recombination dbr:Alpha_helix dbr:Protein_folding dbr:Protein dbc:Protein_domains dbr:Bacteriophage dbr:Virus dbr:Minor_groove dbr:Secondary_structure dbr:Phosphodiester |
| dbp:caption | crystal structure of the lambda xis-dna complex (en) |
| dbp:interpro | IPR012884 (en) |
| dbp:name | Excisionase-like protein (en) |
| dbp:pfam | PF07825 (en) |
| dbp:pfamClan | CL0123 (en) |
| dbp:symbol | Exc (en) |
| dbp:wikiPageUsesTemplate | dbt:Infobox_protein_family dbt:InterPro_content dbt:Reflist |
| dct:subject | dbc:Protein_domains |
| gold:hypernym | dbr:Protein |
| rdf:type | owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 yago:Abstraction100002137 yago:Family108078020 yago:Group100031264 yago:Organization108008335 yago:YagoLegalActor yago:YagoLegalActorGeo yago:YagoPermanentlyLocatedEntity dbo:Protein yago:SocialGroup107950920 yago:Unit108189659 |
| rdfs:comment | In molecular biology, excisionase is a bacteriophage protein encoded by the Xis gene. It is involved in excisive recombination by regulating the assembly of the excisive intasome and by inhibiting viral integration. It adopts an unusual winged-helix structure in which two alpha helices are packed against two extended strands. Also present in the structure is a two-stranded anti-parallel beta-sheet, whose strands are connected by a four-residue wing. During interaction with DNA, helix alpha2 is thought to insert into the major groove, while the wing contacts the adjacent minor groove or phosphodiester backbone. The C-terminal region of excisionase is involved in interaction with phage-encoded integrase (Int), and a putative C-terminal alpha helix may fold upon interaction with Int and/or DN (en) |
| rdfs:label | Excisionase (en) |
| owl:sameAs | freebase:Excisionase wikidata:Excisionase https://global.dbpedia.org/id/8Wqdh |
| prov:wasDerivedFrom | wikipedia-en:Excisionase?oldid=995775470&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/PDB_2og0_EBI.jpg |
| foaf:isPrimaryTopicOf | wikipedia-en:Excisionase |
| is dbo:wikiPageWikiLink of | dbr:Lambda_phage |
| is foaf:primaryTopic of | wikipedia-en:Excisionase |
