FMRFamide (original) (raw)
FMRFamide (H-Phe-Met-Arg-Phe-NH2) is a neuropeptide from a broad family of FMRFamide-related peptides (FaRPs) all sharing an -RFamide sequence at their C-terminus. First identified in Hard clam (Mercenaria mercenaria), it is thought to play an important role in cardiac activity regulation. Several FMRFamide related peptides are known, regulating various cellular functions and possessing pharmacological actions, such as anti-opiate effects. In Mercenaria mercenaria, FMRFamide has been isolated and demonstrated to increase both the force and frequency of the heartbeat through a biochemical pathway that is thought to involve the increase of cytoplasmic cAMP in the ventricular region.
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| dbo:abstract | FMRFamide (H-Phe-Met-Arg-Phe-NH2) is a neuropeptide from a broad family of FMRFamide-related peptides (FaRPs) all sharing an -RFamide sequence at their C-terminus. First identified in Hard clam (Mercenaria mercenaria), it is thought to play an important role in cardiac activity regulation. Several FMRFamide related peptides are known, regulating various cellular functions and possessing pharmacological actions, such as anti-opiate effects. In Mercenaria mercenaria, FMRFamide has been isolated and demonstrated to increase both the force and frequency of the heartbeat through a biochemical pathway that is thought to involve the increase of cytoplasmic cAMP in the ventricular region. FMRFamide is an important neuropeptide in several phyla such as Insecta, Nematoda, Mollusca, and Annelida. It is the most abundant neuropeptide in endocrine cells of insect alimentary tracts along with allatostatin and tachykinin families, however the neuropeptide’s function is not known. Generally, the neuropeptide is encoded by several genes such as flp-1 through flp-22 in C. elegans. The common precursor of the FaRPs is modified to yield many different neuropeptides all having the same FMRFamide sequence. Moreover, these peptides are not functionally redundant. In invertebrates, the FMRFamide-related peptides are known to affect heart rate, blood pressure, gut motility, feeding behaviour and reproduction. In vertebrates such as mice, they are known to affect opioid receptors resulting in elicitation of naloxone-sensitive antinociception and reduction of morphine-induced antinociception. Detection of this neuropeptide is important because its expression lays down the foundation of the CNS in the early stages of development in invertebrates. In recent years, neuromodulatory actions of FMRFamide in invertebrates have become more apparent. This is, in part, due to the extensive studies done on the Planorbid and Lymnaeid families of pond snails. (en) |
| dbo:alternativeName | FMRF amide; H-Phe-Met-Arg-Phe-NH2; (L)-Phenylalanyl-(L)-methionyl-(L)-arginyl-(L)-phenylalaninamide (en) |
| dbo:thumbnail | wiki-commons:Special:FilePath/FMRF_amide.svg?width=300 |
| dbo:wikiPageExternalLink | http://www.abcam.com/index.html%3Fdatasheet=10352&t0=1587883-12317545 |
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| dbo:wikiPageWikiLink | dbr:Caenorhabditis_elegans dbr:Blood_pressure dbr:Allatostatin dbr:Annelida dbr:Neuropeptide dbc:Biomolecules dbr:Endocrine dbr:Mollusca dbr:Morphine dbr:Heart_rate dbr:Cyclic_adenosine_monophosphate dbr:Receptor_(biochemistry) dbr:Reproduction dbc:Neurotransmitters dbr:Hard_clam dbr:C-terminus dbr:Insecta dbr:Opioid dbr:Nematoda dbr:Neuropeptide_VF_precursor dbr:Feeding_behaviour dbr:Gut_motility dbr:Tachykinin |
| dbp:imagefile | FMRF amide.svg (en) |
| dbp:imagesize | 200 (xsd:integer) |
| dbp:othernames | FMRF amide; H-Phe-Met-Arg-Phe-NH2; (L)-Phenylalanyl-(L)-methionyl-(L)-arginyl-(L)-phenylalaninamide (en) |
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| dcterms:subject | dbc:Biomolecules dbc:Neurotransmitters |
| gold:hypernym | dbr:Neuropeptide |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q11173 yago:WikicatNeurotransmitters yago:Abstraction100002137 yago:Chemical114806838 yago:Compound114818238 yago:Material114580897 yago:Matter100020827 yago:Neurochemical114807410 yago:Neurotransmitter114807558 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Relation100031921 dbo:ChemicalCompound dbo:Protein yago:Substance100019613 |
| rdfs:comment | FMRFamide (H-Phe-Met-Arg-Phe-NH2) is a neuropeptide from a broad family of FMRFamide-related peptides (FaRPs) all sharing an -RFamide sequence at their C-terminus. First identified in Hard clam (Mercenaria mercenaria), it is thought to play an important role in cardiac activity regulation. Several FMRFamide related peptides are known, regulating various cellular functions and possessing pharmacological actions, such as anti-opiate effects. In Mercenaria mercenaria, FMRFamide has been isolated and demonstrated to increase both the force and frequency of the heartbeat through a biochemical pathway that is thought to involve the increase of cytoplasmic cAMP in the ventricular region. (en) |
| rdfs:label | FMRFamide (en) |
| owl:sameAs | freebase:FMRFamide yago-res:FMRFamide wikidata:FMRFamide dbpedia-sh:FMRFamide dbpedia-sr:FMRFamide https://global.dbpedia.org/id/4jh69 |
| prov:wasDerivedFrom | wikipedia-en:FMRFamide?oldid=1062645584&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/FMRF_amide.svg |
| foaf:isPrimaryTopicOf | wikipedia-en:FMRFamide |
| is dbo:wikiPageRedirects of | dbr:C29H42N8O4S dbr:Fmrfamide |
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| is foaf:primaryTopic of | wikipedia-en:FMRFamide |
