FXYD2 (original) (raw)
Sodium/potassium-transporting ATPase gamma chain is a protein that in humans is encoded by the FXYD2 gene. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two f
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| dbo:abstract | Sodium/potassium-transporting ATPase gamma chain is a protein that in humans is encoded by the FXYD2 gene. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The Type III integral membrane protein encoded by this gene is the gamma subunit of the Na,K-ATPase present on the plasma membrane. Although the Na,K-ATPase does not depend on the gamma subunit to be functional, it is thought that the gamma subunit modulates the enzyme's activity by inducing ion channel activity. Mutations in this gene have been associated with renal hypomagnesaemia. (en) FXYD2 (англ. FXYD domain containing ion transport regulator 2) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 11-ї хромосоми. Довжина поліпептидного ланцюга білка становить 66 амінокислот, а молекулярна маса — 7 283. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: Валін Y: Тирозин Задіяний у таких біологічних процесах, як транспорт іонів, транспорт, транспорт калію, транспорт натрію, транспорт натрію та калію, альтернативний сплайсинг. Білок має сайт для зв'язування з калію, іоном натрію. Локалізований у мембрані. (uk) |
| dbo:wikiPageExternalLink | http://www.columbia.edu/itc/biology/pollack/w4065/client_edit/readings/nature377_3.pdf |
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| dbo:wikiPageLength | 9129 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1115929674 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Gene |
| dbp:wikiPageUsesTemplate | dbt:Gene-11-stub dbt:Cite_journal dbt:Infobox_gene dbt:Refbegin dbt:Refend dbt:Reflist |
| gold:hypernym | dbr:Protein |
| rdf:type | owl:Thing dbo:Biomolecule dbo:Gene wikidata:Q206229 wikidata:Q7187 dbo:HumanGene dbo:Protein |
| rdfs:comment | Sodium/potassium-transporting ATPase gamma chain is a protein that in humans is encoded by the FXYD2 gene. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two f (en) FXYD2 (англ. FXYD domain containing ion transport regulator 2) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 11-ї хромосоми. Довжина поліпептидного ланцюга білка становить 66 амінокислот, а молекулярна маса — 7 283. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: Валін Y: Тирозин (uk) |
| rdfs:label | FXYD2 (en) FXYD2 (uk) |
| owl:sameAs | freebase:FXYD2 http://www4.wiwiss.fu-berlin.de/diseasome/resource/genes/FXYD2 http://www4.wiwiss.fu-berlin.de/drugbank/resource/targets/253 wikidata:FXYD2 dbpedia-cy:FXYD2 http://tt.dbpedia.org/resource/FXYD2 dbpedia-uk:FXYD2 https://global.dbpedia.org/id/inxL |
| prov:wasDerivedFrom | wikipedia-en:FXYD2?oldid=1115929674&ns=0 |
| foaf:isPrimaryTopicOf | wikipedia-en:FXYD2 |
| is dbo:wikiPageRedirects of | dbr:FXYD2_(gene) |
| is dbo:wikiPageWikiLink of | dbr:FXYD2_(gene) dbr:FXYD5 dbr:List_of_human_protein-coding_genes_2 dbr:Magnesium_deficiency dbr:List_of_OMIM_disorder_codes dbr:FXYD_family |
| is foaf:primaryTopic of | wikipedia-en:FXYD2 |