dbo:abstract |
فلوكسوريدين هو دواء يستعمل في علاج الأورام، من مجموعة مضادات المئيضة، فهو مضاهئ بيريميدين، ومصنف ضمن فئة يوريدين منقوص الأكسجين. (ar) Floxuridine (also 5-fluorodeoxyuridine) is an oncology drug that belongs to the class known as antimetabolites. Specifically, floxuridine is a pyrimidine analog, classified as a deoxyuridine. The drug is usually administered via an artery, and most often used in the treatment of colorectal cancer. The quality of life and survival rates of individuals that receive continuous hepatic artery infusion of floxuridine for colorectal cancer metastases is significantly higher than control groups. Floxuridine can also be prescribed for the treatment of kidney and stomach cancers. In vitro uses of floxuridine include 5-minute treatments of fluorouracil, floxuridine, and mitomycin to increase cell proliferation in Tenon's capsule fibroblasts. (en) Флоксуридин — протипухлинний лікарський засіб, антиметаболіт. Флоксуридин є похідним пиримідинових нуклеозидів, а саме . Використовується у лікуванні раку товстого кишківника. Пацієнти які отримували флоксуридин демонстрували кращі клінічні показники порівняно із контрольною групою. Також інколи використовується для лікування раку нирок та шлунку. (uk) |
dbo:casNumber |
50-91-9 |
dbo:chEBI |
60761 |
dbo:chEMBL |
917 |
dbo:drugbank |
DB00322 |
dbo:fdaUniiCode |
039LU44I5M |
dbo:kegg |
D04197 |
dbo:medlinePlus |
a682006 |
dbo:pubchem |
5790 |
dbo:thumbnail |
wiki-commons:Special:FilePath/Floxuridine.png?width=300 |
dbo:wikiPageID |
3767486 (xsd:integer) |
dbo:wikiPageLength |
12872 (xsd:nonNegativeInteger) |
dbo:wikiPageRevisionID |
1108299975 (xsd:integer) |
dbo:wikiPageWikiLink |
dbr:Caenorhabditis_elegans dbr:Cancers dbr:Carbon_dioxide dbr:Pyrimidine dbr:Mouse dbr:Nucleotide dbr:Methylation dbr:Bilirubin dbr:Deoxyuridine dbr:Antimetabolite dbr:Appetite dbr:Hoffmann-La_Roche dbr:DNA dbr:DNA_synthesis dbr:Uracil dbr:Urea dbr:Derivative_(chemistry) dbr:In_vitro dbr:Infusion dbc:Organofluorides dbc:Pyrimidones dbr:Colorectal_cancer dbr:Nausea dbr:Transaminase dbr:Enzyme dbr:Anemia dbr:Swelling_(medical) dbr:Thymidine dbr:Thymine dbr:Tenon's_capsule dbr:Alkaline_phosphatase dbc:Hydroxymethyl_compounds dbc:Nucleosides dbr:Cytosine dbr:FDA dbr:Fever dbr:Fluorouracil dbr:Diarrhea dbr:Gerontology dbr:Vomiting dbr:RNA dbr:Hair_loss dbr:Fibroblasts dbr:Hand-foot_syndrome dbr:Aeromonas_salmonicida dbr:LD50 dbr:Lactate_dehydrogenase dbr:Dog dbc:Pyrimidine_antagonists dbr:Platelets dbr:F_H_Faulding dbr:Mayne_Pharma dbr:Metastases dbr:National_Cancer_Institute dbr:Oncology dbr:Organisms dbr:Rabbit dbr:Rat dbr:Red_blood_cells dbr:Longevity dbr:Species dbr:Urine dbr:White_blood_cell dbr:Mitomycin dbr:Stomach_ulcers dbr:S-phase dbr:5-fluorouracil dbr:Hepatic_artery dbr:Thymidylate_synthetase dbr:Antimetabolites dbr:Deoxyuridylic_acid dbr:Mouth_sores dbr:5-fluoro-2'-deoxyuridine-5'-phosphate dbr:File:Floxuridine_Biosynthesis.png dbr:Hepatic_metastases dbr:Monophosphate dbr:Thymidylic_acid dbr:Uracil_riboside_phosphorylase |
dbp:atcPrefix |
L01 (en) |
dbp:atcSuffix |
BC09 (en) |
dbp:c |
9 (xsd:integer) |
dbp:casNumber |
50 (xsd:integer) |
dbp:chebi |
60761 (xsd:integer) |
dbp:chembl |
917 (xsd:integer) |
dbp:chemspiderid |
5586 (xsd:integer) |
dbp:drugbank |
DB00322 (en) |
dbp:f |
1 (xsd:integer) |
dbp:h |
11 (xsd:integer) |
dbp:iupacName |
5 (xsd:integer) |
dbp:iupharLigand |
4801 (xsd:integer) |
dbp:kegg |
D04197 (en) |
dbp:medlineplus |
a682006 (en) |
dbp:meltingPoint |
150.500000 (xsd:double) |
dbp:n |
2 (xsd:integer) |
dbp:o |
5 (xsd:integer) |
dbp:pregnancyUs |
D (en) |
dbp:pubchem |
5790 (xsd:integer) |
dbp:routesOfAdministration |
Intra-arterial (en) |
dbp:smiles |
FC=1CNCN[C@@H]2O[C@@H]CO (en) |
dbp:stdinchi |
1 (xsd:integer) |
dbp:stdinchikey |
ODKNJVUHOIMIIZ-RRKCRQDMSA-N (en) |
dbp:unii |
39 (xsd:integer) |
dbp:verifiedrevid |
461100974 (xsd:integer) |
dbp:wikiPageUsesTemplate |
dbt:Chemotherapeutic_agents dbt:Div_col dbt:Div_col_end dbt:Drugbox dbt:LD50 dbt:More_citations_needed dbt:Reflist dbt:Cascite dbt:Chemspidercite dbt:Drugbankcite dbt:Ebicite dbt:Fdacite dbt:Keggcite dbt:Stdinchicite dbt:Drugs.com |
dcterms:subject |
dbc:Organofluorides dbc:Pyrimidones dbc:Hydroxymethyl_compounds dbc:Nucleosides dbc:Pyrimidine_antagonists |
gold:hypernym |
dbr:Drug |
rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:Drug umbel-rc:DrugProduct |
rdfs:comment |
فلوكسوريدين هو دواء يستعمل في علاج الأورام، من مجموعة مضادات المئيضة، فهو مضاهئ بيريميدين، ومصنف ضمن فئة يوريدين منقوص الأكسجين. (ar) Floxuridine (also 5-fluorodeoxyuridine) is an oncology drug that belongs to the class known as antimetabolites. Specifically, floxuridine is a pyrimidine analog, classified as a deoxyuridine. The drug is usually administered via an artery, and most often used in the treatment of colorectal cancer. The quality of life and survival rates of individuals that receive continuous hepatic artery infusion of floxuridine for colorectal cancer metastases is significantly higher than control groups. Floxuridine can also be prescribed for the treatment of kidney and stomach cancers. In vitro uses of floxuridine include 5-minute treatments of fluorouracil, floxuridine, and mitomycin to increase cell proliferation in Tenon's capsule fibroblasts. (en) Флоксуридин — протипухлинний лікарський засіб, антиметаболіт. Флоксуридин є похідним пиримідинових нуклеозидів, а саме . Використовується у лікуванні раку товстого кишківника. Пацієнти які отримували флоксуридин демонстрували кращі клінічні показники порівняно із контрольною групою. Також інколи використовується для лікування раку нирок та шлунку. (uk) |
rdfs:label |
فلوكسوريدين (ar) Floxuridine (en) Флоксуридин (uk) |
owl:sameAs |
freebase:Floxuridine http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugs/DB00322 wikidata:Floxuridine dbpedia-ar:Floxuridine dbpedia-cy:Floxuridine dbpedia-ro:Floxuridine dbpedia-sh:Floxuridine dbpedia-sr:Floxuridine dbpedia-uk:Floxuridine dbpedia-vi:Floxuridine https://global.dbpedia.org/id/4ja9r |
prov:wasDerivedFrom |
wikipedia-en:Floxuridine?oldid=1108299975&ns=0 |
foaf:depiction |
wiki-commons:Special:FilePath/Floxuridine.png wiki-commons:Special:FilePath/Floxuridine_Biosynthesis.png |
foaf:isPrimaryTopicOf |
wikipedia-en:Floxuridine |
is dbo:wikiPageRedirects of |
dbr:FUDR dbr:FUdR dbr:Fluorodeoxyuridine dbr:5-fluoro-2'-deoxyuridine dbr:5-fluorodeoxyuridine |
is dbo:wikiPageWikiLink of |
dbr:FUDR dbr:List_of_antineoplastic_agents dbr:Antimetabolite dbr:Index_of_oncology_articles dbr:Pyrimidine_analogue dbr:Fluorodeoxyuridylate dbr:List_of_MeSH_codes_(D13) dbr:ATC_code_L01 dbr:Hepatic_arterial_infusion dbr:C9H11FN2O5 dbr:Clastogen dbr:FUdR dbr:National_Cancer_Institute dbr:List_of_drugs:_Fl dbr:Fluorodeoxyuridine dbr:5-fluoro-2'-deoxyuridine dbr:5-fluorodeoxyuridine |
is foaf:primaryTopic of |
wikipedia-en:Floxuridine |