Flutemazepam (original) (raw)
Le flutémazépam est une benzodiazépine qui n'est pas commercialisée en France. C'est la même molécule que le témazépam à l'exception qu'il y'a un atome de fluor sur le cycle phényle en position R2'. D'où son nom: flu-témazépam.Cette molécule ressemble également au fludiazépam. C'est la même molécule à l'exception qu'il y'a un groupe hydroxyle en position 3.
| Property | Value |
|---|---|
| dbo:abstract | Flutemazepam, initially first synthesized in 1965, but wasn't further developed and described until a team at Stabilimenti Chimici Farmaceutici Riuniti SpA in the mid 1970s. It is the fluorinated analogue of temazepam that has powerful hypnotic, sedative, amnesiac, anxiolytic, anticonvulsant and skeletal muscle relaxant properties. It is most closely related in structure to temazepam, being the fluoro instead of chloro analogue. As a result, flutemazepam has been shown to have similar pharmacological properties to temazepam and nimetazepam. It has been found to be effective for the treatment of the most severe states of anxiety, panic attacks, and severe insomnia. Furthermore, it is highly potent with 1 mg of flutemazepam being equivalent to 10 mg of diazepam. Flutemazepam is highly effective for acute psychotic states, especially stimulant psychosis, violent behaviour, and aggression. It was first synthesized and described in 1965 by Leo Sternbach. In a test which compared a series of 3-fluorobenzodiazepine compounds in 1976, one of which was the 3-hydroxy benzodiazepine, flutemazepam. Of the tested compounds (9 different 3-fluorobenzodiazepines including, a powerful compound known as N-Desalkyl-3-hydroxyflurazepam). Flutemazepam was the most potent: 20x more potent than temazepam, 10x more potent than diazepam and nitrazepam, 5x more potent than nimetazepam and roughly equipotent to a related 3-hydroxy benzodiazepine, lorazepam. It was also the most rapid-acting compound of the series via oral administration, as well as the most active and powerful anxiolytic, myorelaxant, tranquilizer, motor-impairing, amnesic, sedative-hypnotic, and anti-convulsive agent at doses as low as 0.5-1 mg range. (en) Le flutémazépam est une benzodiazépine qui n'est pas commercialisée en France. C'est la même molécule que le témazépam à l'exception qu'il y'a un atome de fluor sur le cycle phényle en position R2'. D'où son nom: flu-témazépam.Cette molécule ressemble également au fludiazépam. C'est la même molécule à l'exception qu'il y'a un groupe hydroxyle en position 3. (fr) Il flutemazepam è uno psicofarmaco appartenente alla categoria delle benzodiazepine, sviluppato da un team degli Stabilimenti Chimici Farmaceutici Riuniti SpA nel 1975. Questo farmaco è un analogo del temazepam che ha proprietà ipnotiche, sedative, amnesiche, ansiolitiche, anticonvulsivanti e miorilassanti scheletrici. (it) |
| dbo:casNumber | 52391-89-6 |
| dbo:chEMBL | 291770 |
| dbo:fdaUniiCode | J8U5694BCW |
| dbo:pubchem | 40344 |
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| dbp:legalCa | Schedule IV (en) |
| dbp:legalDe | NpSG (en) |
| dbp:legalUk | PSA (en) |
| dbp:legalUn | P IV (en) |
| dbp:legalUs | Schedule IV (en) |
| dbp:molecularWeight | 318.730000 (xsd:double) |
| dbp:n | 2 (xsd:integer) |
| dbp:o | 2 (xsd:integer) |
| dbp:pregnancyCategory | X (en) |
| dbp:pubchem | 40344 (xsd:integer) |
| dbp:routesOfAdministration | Oral (en) |
| dbp:smiles | FC1=CC=CC=C1C2=NCO (en) |
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| rdfs:comment | Le flutémazépam est une benzodiazépine qui n'est pas commercialisée en France. C'est la même molécule que le témazépam à l'exception qu'il y'a un atome de fluor sur le cycle phényle en position R2'. D'où son nom: flu-témazépam.Cette molécule ressemble également au fludiazépam. C'est la même molécule à l'exception qu'il y'a un groupe hydroxyle en position 3. (fr) Il flutemazepam è uno psicofarmaco appartenente alla categoria delle benzodiazepine, sviluppato da un team degli Stabilimenti Chimici Farmaceutici Riuniti SpA nel 1975. Questo farmaco è un analogo del temazepam che ha proprietà ipnotiche, sedative, amnesiche, ansiolitiche, anticonvulsivanti e miorilassanti scheletrici. (it) Flutemazepam, initially first synthesized in 1965, but wasn't further developed and described until a team at Stabilimenti Chimici Farmaceutici Riuniti SpA in the mid 1970s. It is the fluorinated analogue of temazepam that has powerful hypnotic, sedative, amnesiac, anxiolytic, anticonvulsant and skeletal muscle relaxant properties. It is most closely related in structure to temazepam, being the fluoro instead of chloro analogue. As a result, flutemazepam has been shown to have similar pharmacological properties to temazepam and nimetazepam. It has been found to be effective for the treatment of the most severe states of anxiety, panic attacks, and severe insomnia. Furthermore, it is highly potent with 1 mg of flutemazepam being equivalent to 10 mg of diazepam. Flutemazepam is highly effect (en) |
| rdfs:label | Flutemazepam (en) Flutemazepam (it) Flutémazépam (fr) |
| owl:sameAs | freebase:Flutemazepam yago-res:Flutemazepam wikidata:Flutemazepam dbpedia-fr:Flutemazepam dbpedia-it:Flutemazepam dbpedia-sh:Flutemazepam dbpedia-sr:Flutemazepam dbpedia-vi:Flutemazepam https://global.dbpedia.org/id/4jL6F |
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