Formetorex (original) (raw)
Formetorex (INN), also known as formetamide or N-formylamphetamine, is a substituted amphetamine described as an anorectic which does not appear to have ever been marketed. Formetorex is also an intermediate in the production of amphetamine by the "Leuckart reaction." It is also commonly found as an impurity in clandestine labs where this synthesis method is used. Due to the simplicity of the Leuckart reaction, it is the most popular synthetic route employed for the illicit manufacture of amphetamines. The synthesis involves a non-metal reduction that is typically carried out in three steps. For amphetamine synthesis, a mixture of phenylacetone and formamide (sometimes in the presence of formic acid) or ammonium formate, is heated until a condensation reaction results in the intermediate p
| Property | Value |
|---|---|
| dbo:abstract | Formetorex (INN), also known as formetamide or N-formylamphetamine, is a substituted amphetamine described as an anorectic which does not appear to have ever been marketed. Formetorex is also an intermediate in the production of amphetamine by the "Leuckart reaction." It is also commonly found as an impurity in clandestine labs where this synthesis method is used. Due to the simplicity of the Leuckart reaction, it is the most popular synthetic route employed for the illicit manufacture of amphetamines. The synthesis involves a non-metal reduction that is typically carried out in three steps. For amphetamine synthesis, a mixture of phenylacetone and formamide (sometimes in the presence of formic acid) or ammonium formate, is heated until a condensation reaction results in the intermediate product, formetamide. In the second step, formetamide is hydrolysed using hydrochloric acid, and the reaction mixture is then basified, isolated, and steam distilled to produce the free base. The final step, the product is dissolved in an organic solvent and precipitated as the sulphate salt of amphetamine by adding sulfuric acid. (en) |
| dbo:alternativeName | Formetorex (en) N-Formylamphetamine (en) N-(alpha-Methylphenethyl)formamide (en) |
| dbo:iupacName | N-(1-Phenylpropan-2-yl)formamide (en) |
| dbo:thumbnail | wiki-commons:Special:FilePath/N-formylamphetamine.png?width=300 |
| dbo:wikiPageID | 40886967 (xsd:integer) |
| dbo:wikiPageLength | 3758 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1039853578 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Anorectic dbr:Substituted_amphetamine dbc:Stimulants dbr:Leuckart_reaction dbc:Formamides dbr:Ammonium_formate dbr:Amphetamine dbc:Amphetamine dbr:Formamide dbr:Formic_acid dbc:Anorectics dbc:Norepinephrine-dopamine_releasing_agents dbc:Substituted_amphetamines dbr:International_Nonproprietary_Name dbr:Phenylacetone dbr:Chemical_intermediate |
| dbp:align | center (en) |
| dbp:alt | Diagram of amphetamine synthesis via the Leuckart reaction (en) |
| dbp:caption | Amphetamine synthesis via the Leuckart reaction (en) |
| dbp:height | 100 (xsd:integer) |
| dbp:icon | none (en) |
| dbp:imageWidth | 600 (xsd:integer) |
| dbp:imagealt | An image of formetamide (en) |
| dbp:imagefile | N-formylamphetamine.png (en) |
| dbp:imagesize | 200 (xsd:integer) |
| dbp:othernames | Formetorex (en) N-Formylamphetamine (en) N-formamide (en) |
| dbp:pin | N-formamide (en) |
| dbp:width | 600 (xsd:integer) |
| dbp:wikiPageUsesTemplate | dbt:Amphetamine dbt:Annotated_image_4 dbt:Chembox dbt:Chembox_Hazards dbt:Chembox_Identifiers dbt:Chembox_Properties dbt:MeshName dbt:Nervous-system-drug-stub dbt:Phenethylamines dbt:Reflist dbt:Stimulants dbt:Cascite dbt:Anorectics |
| dcterms:subject | dbc:Stimulants dbc:Formamides dbc:Amphetamine dbc:Anorectics dbc:Norepinephrine-dopamine_releasing_agents dbc:Substituted_amphetamines |
| gold:hypernym | dbr:Amphetamine |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q11173 yago:WikicatAmphetamines yago:Agent114778436 yago:Amphetamine102704153 yago:CausalAgent100007347 yago:Drug103247620 yago:DrugOfAbuse103248958 yago:Matter100020827 yago:PhysicalEntity100001930 dbo:ChemicalCompound dbo:Drug yago:Stimulant104320126 yago:Substance100020090 |
| rdfs:comment | Formetorex (INN), also known as formetamide or N-formylamphetamine, is a substituted amphetamine described as an anorectic which does not appear to have ever been marketed. Formetorex is also an intermediate in the production of amphetamine by the "Leuckart reaction." It is also commonly found as an impurity in clandestine labs where this synthesis method is used. Due to the simplicity of the Leuckart reaction, it is the most popular synthetic route employed for the illicit manufacture of amphetamines. The synthesis involves a non-metal reduction that is typically carried out in three steps. For amphetamine synthesis, a mixture of phenylacetone and formamide (sometimes in the presence of formic acid) or ammonium formate, is heated until a condensation reaction results in the intermediate p (en) |
| rdfs:label | Formetorex (en) |
| owl:sameAs | freebase:Formetorex yago-res:Formetorex wikidata:Formetorex dbpedia-sh:Formetorex dbpedia-sr:Formetorex https://global.dbpedia.org/id/YH2v |
| prov:wasDerivedFrom | wikipedia-en:Formetorex?oldid=1039853578&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Amphetamine_-_Leuckart_reaction.png wiki-commons:Special:FilePath/N-formylamphetamine.png |
| foaf:isPrimaryTopicOf | wikipedia-en:Formetorex |
| is dbo:wikiPageRedirects of | dbr:N-formylamphetamine dbr:Formetamide dbr:N-(1-phenylpropan-2-yl)formamide dbr:N-(alpha-Methylphenethyl)formamide dbr:N-(alpha-methylphenethyl)-formamide dbr:N-formylamfetamine |
| is dbo:wikiPageWikiLink of | dbr:N-formylamphetamine dbr:Formetamide dbr:N-(1-phenylpropan-2-yl)formamide dbr:N-(alpha-Methylphenethyl)formamide dbr:N-(alpha-methylphenethyl)-formamide dbr:N-formylamfetamine dbr:List_of_drugs:_Fm–Ft |
| is foaf:primaryTopic of | wikipedia-en:Formetorex |
