Framework region (original) (raw)
In molecular biology, a framework region is a subdivision of the variable region (Fab) of the antibody. The variable region is composed of seven amino acid regions, four of which are framework regions and three of which are hypervariable regions. The framework region makes up about 85% of the variable region. Located on the tips of the Y-shaped molecule, the framework regions are responsible for acting as a scaffold for the complementarity determining regions (CDR), also referred to as hypervariable regions, of the Fab. These CDRs are in direct contact with the antigen and are involved in binding antigen, while the framework regions support the binding of the CDR to the antigen and aid in maintaining the overall structure of the four variable domains on the antibody. To increase its stabil
| Property | Value |
|---|---|
| dbo:abstract | In molecular biology, a framework region is a subdivision of the variable region (Fab) of the antibody. The variable region is composed of seven amino acid regions, four of which are framework regions and three of which are hypervariable regions. The framework region makes up about 85% of the variable region. Located on the tips of the Y-shaped molecule, the framework regions are responsible for acting as a scaffold for the complementarity determining regions (CDR), also referred to as hypervariable regions, of the Fab. These CDRs are in direct contact with the antigen and are involved in binding antigen, while the framework regions support the binding of the CDR to the antigen and aid in maintaining the overall structure of the four variable domains on the antibody. To increase its stability, the framework region has less variability in its amino acid sequences compared to the CDR. (en) |
| dbo:thumbnail | wiki-commons:Special:FilePath/Antibody_Structure_and_Antigen_Binding_Regions.jpg?width=300 |
| dbo:wikiPageID | 22409299 (xsd:integer) |
| dbo:wikiPageLength | 9152 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1092982788 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Antigen dbr:Antibody dbr:Complementarity-determining_region dbr:Somatic_hypermutation dbc:Proteins dbr:Activation-induced_cytidine_deaminase dbr:Mutagen dbr:Hypervariable_region dbc:Antibodies dbr:Humanized_antibody dbr:Immunoglobulin_class_switching dbr:Molecular_biology dbr:File:Antibody_Structure_and_Antigen_Binding_Regions.jpg |
| dbp:wikiPageUsesTemplate | dbt:Reflist |
| dct:subject | dbc:Proteins dbc:Antibodies |
| gold:hypernym | dbr:Region |
| rdf:type | yago:WikicatAntibodies yago:Abstraction100002137 yago:Antibody115027189 yago:Chemical114806838 yago:Compound114818238 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 dbo:Settlement yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 yago:WikicatProteins |
| rdfs:comment | In molecular biology, a framework region is a subdivision of the variable region (Fab) of the antibody. The variable region is composed of seven amino acid regions, four of which are framework regions and three of which are hypervariable regions. The framework region makes up about 85% of the variable region. Located on the tips of the Y-shaped molecule, the framework regions are responsible for acting as a scaffold for the complementarity determining regions (CDR), also referred to as hypervariable regions, of the Fab. These CDRs are in direct contact with the antigen and are involved in binding antigen, while the framework regions support the binding of the CDR to the antigen and aid in maintaining the overall structure of the four variable domains on the antibody. To increase its stabil (en) |
| rdfs:label | Framework region (en) |
| owl:sameAs | freebase:Framework region yago-res:Framework region wikidata:Framework region https://global.dbpedia.org/id/4k1Zk |
| prov:wasDerivedFrom | wikipedia-en:Framework_region?oldid=1092982788&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Antibody_Structure_and_Antigen_Binding_Regions.jpg |
| foaf:isPrimaryTopicOf | wikipedia-en:Framework_region |
| is dbo:wikiPageDisambiguates of | dbr:Framework |
| is dbo:wikiPageWikiLink of | dbr:Complementarity-determining_region dbr:T-cell_receptor dbr:Inotuzumab_ozogamicin dbr:Superantigen dbr:Framework dbr:Outline_of_immunology |
| is foaf:primaryTopic of | wikipedia-en:Framework_region |
