Frzb (original) (raw)

Frzb (pronounced like the toy frisbee) is a Wnt-binding protein especially important in embryonic development. It is a competitor for the cell-surface G-protein receptor Frizzled. Frizzled is a in Drosophila melanogaster and encodes integral proteins that function as cell-surface receptors for Wnts called . The integral membrane proteins contain a cysteine-rich domain thought to be the Wnt binding domain in extracellular region. The signals are initiated at the 7 transmembrane domain and transmitted through receptor coupling to G-proteins.