GHMP kinase family (original) (raw)
In molecular biology, the GHMP kinase family is a family of kinase enzymes. Members of this family include homoserine kinases EC 2.7.1.39, galactokinases EC 2.7.1.6, and mevalonate kinasesEC 2.7.1.36. These kinases make up the GHMP kinase superfamily of ATP-dependent enzymes. These enzymes are involved in the biosynthesis of isoprenes and amino acids as well as in carbohydrate metabolism. These enzymes contain, in their N-terminal section, a conserved Gly/Ser-rich region which is probably involved in the binding of ATP. The C-terminal domain of homoserine kinase has a central alpha-beta plait fold and an insertion of four helices, which, together with the N-terminal fold, creates a novel nucleotide binding fold.
| Property | Value |
|---|---|
| dbo:abstract | In molecular biology, the GHMP kinase family is a family of kinase enzymes. Members of this family include homoserine kinases EC 2.7.1.39, galactokinases EC 2.7.1.6, and mevalonate kinasesEC 2.7.1.36. These kinases make up the GHMP kinase superfamily of ATP-dependent enzymes. These enzymes are involved in the biosynthesis of isoprenes and amino acids as well as in carbohydrate metabolism. These enzymes contain, in their N-terminal section, a conserved Gly/Ser-rich region which is probably involved in the binding of ATP. The C-terminal domain of homoserine kinase has a central alpha-beta plait fold and an insertion of four helices, which, together with the N-terminal fold, creates a novel nucleotide binding fold. (en) |
| dbo:symbol | GHMP_kinases_C GHMP_kinases_N |
| dbo:thumbnail | wiki-commons:Special:FilePath/PDB_1k47_EBI.jpg?width=300 |
| dbo:wikiPageID | 32998515 (xsd:integer) |
| dbo:wikiPageLength | 3425 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1032255022 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Carbohydrate dbr:Nucleotide dbr:Mevalonate_kinase dbr:C-terminal dbc:Protein_families dbr:Enzyme dbr:Enzymes dbr:Galactokinase dbr:Glycine dbr:Conserved_sequence dbr:Alpha_helices dbr:Adenosine_triphosphate dbr:Amino_acid dbr:Kinase dbr:Protein_family dbr:Protein_folding dbr:Isoprene dbr:Biosynthesis dbr:Homoserine_kinase dbr:Metabolism dbr:Serine dbr:Superfamily_(molecular_biology) dbr:N-terminal |
| dbp:caption | crystal structure of the streptococcus pneumoniae phosphomevalonate kinase (en) pyrococcus furiosus galactokinase in complex with galactose, adp and magnesium (en) |
| dbp:interpro | IPR006204 (en) IPR013750 (en) |
| dbp:name | GHMP kinases C terminal (en) GHMP kinases N terminal domain (en) |
| dbp:pfam | PF00288 (en) PF08544 (en) |
| dbp:pfamClan | CL0329 (en) |
| dbp:prosite | PDOC00545 (en) |
| dbp:scop | 1 (xsd:integer) |
| dbp:symbol | GHMP_kinases_C (en) GHMP_kinases_N (en) |
| dbp:wikiPageUsesTemplate | dbt:EC_number dbt:Infobox_protein_family dbt:InterPro_content dbt:Reflist |
| dcterms:subject | dbc:Protein_families |
| gold:hypernym | dbr:Family |
| rdf:type | owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 dbo:Protein |
| rdfs:comment | In molecular biology, the GHMP kinase family is a family of kinase enzymes. Members of this family include homoserine kinases EC 2.7.1.39, galactokinases EC 2.7.1.6, and mevalonate kinasesEC 2.7.1.36. These kinases make up the GHMP kinase superfamily of ATP-dependent enzymes. These enzymes are involved in the biosynthesis of isoprenes and amino acids as well as in carbohydrate metabolism. These enzymes contain, in their N-terminal section, a conserved Gly/Ser-rich region which is probably involved in the binding of ATP. The C-terminal domain of homoserine kinase has a central alpha-beta plait fold and an insertion of four helices, which, together with the N-terminal fold, creates a novel nucleotide binding fold. (en) |
| rdfs:label | GHMP kinase family (en) |
| owl:sameAs | freebase:GHMP kinase family wikidata:GHMP kinase family https://global.dbpedia.org/id/7Zhfv |
| prov:wasDerivedFrom | wikipedia-en:GHMP_kinase_family?oldid=1032255022&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/PDB_1k47_EBI.jpg wiki-commons:Special:FilePath/PDB_1s4e_EBI.jpg |
| foaf:isPrimaryTopicOf | wikipedia-en:GHMP_kinase_family |
| is dbo:wikiPageWikiLink of | dbr:Galactokinase dbr:Diphosphomevalonate_decarboxylase |
| is foaf:primaryTopic of | wikipedia-en:GHMP_kinase_family |
