GalNAc-T activation pathway (original) (raw)

The GalNAc-T activation (GALA) pathway is a cellular process in which GalNAc-T enzymes, involved in O-linked glycosylation, are relocated from the Golgi to the ER. Activation of the pathway is thought to result in the alteration of the glycosylation status of a number of GalNAc-T substrates. This pathway was shown to be highly activated in cancer cells and was proposed as an explanation of the noticeable increased expression of Tn antigen seen in tumours.