| dbo:abstract |
Ganirelix acetate (or diacetate), sold under the brand names Orgalutran and Antagon among others, is an injectable competitive gonadotropin-releasing hormone antagonist (GnRH antagonist). It is primarily used in assisted reproduction to control ovulation. The drug works by blocking the action of GnRH upon the pituitary, thus rapidly suppressing the production and action of LH and FSH. Ganirelix is used in fertility treatment to prevent premature ovulation that could result in the harvesting of eggs that are too immature to be used in procedures such as in vitro fertilization. GnRH agonists are also sometimes used in reproductive therapy, as well as to treat disorders involving sex-steroid hormones, such as endometriosis. One advantage of using GnRH antagonists is that repeated administration of GnRH agonists results in decreased levels of gonadotropins and sex steroids due to desensitization of the pituitary. This is avoided when using GnRH antagonists such as ganirelix. The success of ganirelix in reproductive therapy has been shown to be comparable to that when using GnRH agonists. (en) Il ganirelix acetato (o diacetato) è un antagonista del GnRH selettivo dell'ormone di rilascio delle gonadotropine (GnRH) impiegato come trattamento farmacologico della riproduzione assistita per controllare l'ovulazione. Il farmaco agisce bloccando l'azione del GnRH sulla ipofisi, così rapidamente da sopprimere la produzione e l'azione degli ormoni LH e FSH. Il ganirelix è usato nel trattamento della infertilità per prevenire l'ovulazione prematura causata dalla raccolta di ovociti immaturi, per essere utilizzati nelle procedure di fecondazione in vitro. (it) |
| dbo:alternativeName |
Orgalutran, Antagon, others (en) |
| dbo:bioavailability |
91.099998 (xsd:float) |
| dbo:casNumber |
124904-93-4 |
| dbo:chEMBL |
1251 |
| dbo:class |
dbr:Antigonadotropin dbr:GnRH_analogue dbr:GnRH_antagonist |
| dbo:drugbank |
DB06785 |
| dbo:fdaUniiCode |
IX503L9WN0 |
| dbo:kegg |
D04302 D08010 |
| dbo:pubchem |
16186319 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Ganirelix.svg?width=300 |
| dbo:wikiPageExternalLink |
https://druginfo.nlm.nih.gov/drugportal/name/ganirelix https://druginfo.nlm.nih.gov/drugportal/name/ganirelix%20acetate |
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dbr:Antigonadotropin dbc:Fertility_medicine dbr:Endometriosis dbr:Gonadotropin-releasing_hormone_agonist dbr:Gonadotropin-releasing_hormone_antagonist dbr:Controlled_ovarian_hyperstimulation dbr:Subcutaneous_injection dbr:Feces dbr:Ovulation dbr:Follicle-stimulating_hormone dbr:Gonadotropin-releasing_hormone dbr:Gonadotropin-releasing_hormone_receptor dbc:Peptides dbc:GnRH_antagonists dbc:Merck_&_Co._brands dbr:In_vitro_fertilization dbr:Urine dbr:Luteinizing_hormone dbr:Reproductive_technology dbr:GnRH_analogue dbr:GnRH_antagonist dbr:Human_chorionic_gonadotrophin |
| dbp:atcPrefix |
H01 (en) |
| dbp:atcSuffix |
CC01 (en) |
| dbp:bioavailability |
91.1 (dbd:perCent) |
| dbp:c |
80 (xsd:integer) |
| dbp:casNumber |
124904 (xsd:integer) |
| dbp:chembl |
1251 (xsd:integer) |
| dbp:chemspiderid |
16736620 (xsd:integer) |
| dbp:cl |
1 (xsd:integer) |
| dbp:class |
dbr:Antigonadotropin dbr:GnRH_analogue dbr:GnRH_antagonist |
| dbp:dailymedid |
Ganirelix (en) |
| dbp:drugbank |
DB06785 (en) |
| dbp:eliminationHalfLife |
58320.0 (dbd:second) |
| dbp:excretion |
Feces: 75% (en) Urine: 22% (en) |
| dbp:h |
113 (xsd:integer) |
| dbp:index2Label |
as salt (en) |
| dbp:iupacName |
-1 (xsd:integer) |
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3877 (xsd:integer) |
| dbp:kegg |
D04302 (en) D08010 (en) |
| dbp:legalAu |
S4 (en) |
| dbp:legalUs |
Rx-only (en) |
| dbp:licenceEu |
yes (en) |
| dbp:n |
18 (xsd:integer) |
| dbp:o |
13 (xsd:integer) |
| dbp:pregnancyAu |
D (en) |
| dbp:pregnancyUs |
X (en) |
| dbp:proteinBound |
81.9 (dbd:perCent) |
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16186319 (xsd:integer) |
| dbp:routesOfAdministration |
dbr:Subcutaneous_injection |
| dbp:smiles |
CCNCNCC (en) |
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1 (xsd:integer) |
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GJNXBNATEDXMAK-PFLSVRRQSA-N (en) |
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Orgalutran, Antagon, others (en) |
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IX503L9WN0 (en) |
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changed (en) |
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461118874 (xsd:integer) |
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250 (xsd:integer) |
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| dct:subject |
dbc:Fertility_medicine dbc:Peptides dbc:GnRH_antagonists dbc:Merck_&_Co._brands |
| gold:hypernym |
dbr:Antagonist |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:Adversary109773245 yago:CausalAgent100007347 yago:LivingThing100004258 yago:Object100002684 yago:Organism100004475 yago:Person100007846 yago:PhysicalEntity100001930 yago:WikicatGnRHAntagonists yago:YagoLegalActor yago:YagoLegalActorGeo dbo:Drug yago:Whole100003553 umbel-rc:DrugProduct |
| rdfs:comment |
Il ganirelix acetato (o diacetato) è un antagonista del GnRH selettivo dell'ormone di rilascio delle gonadotropine (GnRH) impiegato come trattamento farmacologico della riproduzione assistita per controllare l'ovulazione. Il farmaco agisce bloccando l'azione del GnRH sulla ipofisi, così rapidamente da sopprimere la produzione e l'azione degli ormoni LH e FSH. Il ganirelix è usato nel trattamento della infertilità per prevenire l'ovulazione prematura causata dalla raccolta di ovociti immaturi, per essere utilizzati nelle procedure di fecondazione in vitro. (it) Ganirelix acetate (or diacetate), sold under the brand names Orgalutran and Antagon among others, is an injectable competitive gonadotropin-releasing hormone antagonist (GnRH antagonist). It is primarily used in assisted reproduction to control ovulation. The drug works by blocking the action of GnRH upon the pituitary, thus rapidly suppressing the production and action of LH and FSH. Ganirelix is used in fertility treatment to prevent premature ovulation that could result in the harvesting of eggs that are too immature to be used in procedures such as in vitro fertilization. (en) |
| rdfs:label |
Ganirelix (en) Ganirelix (it) |
| owl:sameAs |
freebase:Ganirelix yago-res:Ganirelix wikidata:Ganirelix dbpedia-cy:Ganirelix dbpedia-da:Ganirelix dbpedia-he:Ganirelix dbpedia-it:Ganirelix dbpedia-sh:Ganirelix dbpedia-sr:Ganirelix dbpedia-vi:Ganirelix https://global.dbpedia.org/id/4juZG |
| prov:wasDerivedFrom |
wikipedia-en:Ganirelix?oldid=1106834632&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/Ganirelix.svg |
| foaf:isPrimaryTopicOf |
wikipedia-en:Ganirelix |
| is dbo:wikiPageRedirects of |
dbr:ATC_code_H01CC01 dbr:ATCvet_code_QH01CC01 dbr:Orgalutran dbr:Ganirelix_acetate dbr:Antagon |
| is dbo:wikiPageWikiLink of |
dbr:List_of_compounds_with_carbon_numbers_50+ dbr:Gonadotropin-releasing_hormone_antagonist dbr:Gonadotropin-releasing_hormone_modulator dbr:Gonadotropin-releasing_hormone_receptor dbr:ATC_code_H01CC01 dbr:ATCvet_code_QH01CC01 dbr:ATC_code_H01 dbr:Non-surgical_fertility_control_for_dogs_and_cats dbr:List_of_drugs:_G dbr:Orgalutran dbr:Ganirelix_acetate dbr:Antagon |
| is foaf:primaryTopic of |
wikipedia-en:Ganirelix |
