Genes to Cognition Project (original) (raw)
Genes to Cognition (G2C) is a neuroscience research programme that studies genes, the brain and behaviour in an integrated manner. It is engaged in a large-scale investigation of the function of molecules found at the synapse. This is mainly focused on proteins that interact with the NMDA receptor, a receptor for the neurotransmitter, glutamate, which is required for processes of synaptic plasticity such as long-term potentiation (LTP). One key discovery that led to the G2C project was the characterization of a group of proteins that interact with this receptor, called the "NMDA Receptor Complex (NRC)" and the observation that dysfunctions of many of these proteins are characteristic of numerous diseases of the nervous system. The NRC contains 185 proteins, 48 of which have so far been imp
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| dbo:abstract | Genes to Cognition (G2C) is a neuroscience research programme that studies genes, the brain and behaviour in an integrated manner. It is engaged in a large-scale investigation of the function of molecules found at the synapse. This is mainly focused on proteins that interact with the NMDA receptor, a receptor for the neurotransmitter, glutamate, which is required for processes of synaptic plasticity such as long-term potentiation (LTP). One key discovery that led to the G2C project was the characterization of a group of proteins that interact with this receptor, called the "NMDA Receptor Complex (NRC)" and the observation that dysfunctions of many of these proteins are characteristic of numerous diseases of the nervous system. The NRC contains 185 proteins, 48 of which have so far been implicated in 54 human nervous system disorders. The molecular evolution of the NRC is also an active area of research, and it has been shown that an increase in the complexity of these signaling proteins at synapses has evolved alongside the enhanced cognitive capacities of humans and other higher vertebrates. (en) |
| dbo:wikiPageExternalLink | http://www.g2conline.org http://www.genes2cognition.org https://web.archive.org/web/20080613083459/http:/www.genes2cognition.org/cgi-bin/LiteratureView%3Ftype=g2c |
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| dbo:wikiPageWikiLink | dbr:Behavior dbc:Neuroscience_projects dbr:Neurotransmitter dbr:James_D._Watson dbc:Population_genetics_organizations dbr:Chemical_synapse dbr:Gene dbr:Brain dbr:Synaptic_plasticity dbr:Long-term_potentiation dbr:Eric_Kandel dbr:List_of_Nobel_laureates dbr:Human_Genome_Project dbr:Open_access_(publishing) dbr:Neuroscience dbr:NMDA_receptor dbr:Molecular_evolution dbr:Postsynaptic_density dbr:The_1000_Genomes_Project dbr:Glutamate |
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| dct:subject | dbc:Neuroscience_projects dbc:Population_genetics_organizations |
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| rdfs:comment | Genes to Cognition (G2C) is a neuroscience research programme that studies genes, the brain and behaviour in an integrated manner. It is engaged in a large-scale investigation of the function of molecules found at the synapse. This is mainly focused on proteins that interact with the NMDA receptor, a receptor for the neurotransmitter, glutamate, which is required for processes of synaptic plasticity such as long-term potentiation (LTP). One key discovery that led to the G2C project was the characterization of a group of proteins that interact with this receptor, called the "NMDA Receptor Complex (NRC)" and the observation that dysfunctions of many of these proteins are characteristic of numerous diseases of the nervous system. The NRC contains 185 proteins, 48 of which have so far been imp (en) |
| rdfs:label | Genes to Cognition Project (en) |
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| prov:wasDerivedFrom | wikipedia-en:Genes_to_Cognition_Project?oldid=1066249877&ns=0 |
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