Granulocyte colony-stimulating factor receptor (original) (raw)
The granulocyte colony-stimulating factor receptor (G-CSF-R) also known as CD114 (Cluster of Differentiation 114) is a protein that in humans is encoded by the CSF3R gene. G-CSF-R is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF). The G-CSF receptors belongs to a family of cytokine receptors known as the hematopoietin receptor family. The granulocyte colony-stimulating factor receptor is present on precursor cells in the bone marrow, and, in response to stimulation by G-CSF, initiates cell proliferation and differentiation into mature neutrophilic granulocytes and macrophages.
| Property | Value |
|---|---|
| dbo:abstract | The granulocyte colony-stimulating factor receptor (G-CSF-R) also known as CD114 (Cluster of Differentiation 114) is a protein that in humans is encoded by the CSF3R gene. G-CSF-R is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF). The G-CSF receptors belongs to a family of cytokine receptors known as the hematopoietin receptor family. The granulocyte colony-stimulating factor receptor is present on precursor cells in the bone marrow, and, in response to stimulation by G-CSF, initiates cell proliferation and differentiation into mature neutrophilic granulocytes and macrophages. The G-CSF-R is a transmembrane receptor that consists of an extracellular ligand-binding portion, a transmembrane domain, and the cytoplasmic portion that is responsible for signal transduction. GCSF-R ligand-binding is associated with dimerization of the receptor and signal transduction through proteins including Jak, Lyn, STAT, and Erk1/2. (en) CSF3R (англ. Colony stimulating factor 3 receptor) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 1-ї хромосоми. Довжина поліпептидного ланцюга білка становить 836 амінокислот, а молекулярна маса — 92 156. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Кодований геном білок за функцією належить до рецепторів. Задіяний у такому біологічному процесі як клітинна адгезія. Локалізований у клітинній мембрані, мембрані.Також секретований назовні. (uk) |
| dbo:wikiPageExternalLink | http://repub.eur.nl/pub/60338 |
| dbo:wikiPageID | 9623448 (xsd:integer) |
| dbo:wikiPageLength | 13439 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1092816857 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Protein-protein_interaction dbr:Mutation dbr:Cytokine dbr:STAT_protein dbr:Gene dbr:Granulocytes dbr:Leukemia dbr:Macrophages dbr:Cluster_of_differentiation dbc:Type_I_cytokine_receptors dbr:Cell_(biology) dbr:HCK dbr:Janus_kinase dbr:Grb2 dbr:Erythropoietin dbr:Cell_proliferation dbr:Cellular_differentiation dbr:Granulocyte_colony-stimulating_factor dbr:Protein_dimer dbr:Protein dbr:Receptor_(biochemistry) dbr:Transmembrane_protein dbc:Clusters_of_differentiation dbr:Signal_transduction dbr:Bone_marrow dbr:Severe_congenital_neutropenia dbr:Lyn_(Src_family_kinase) dbr:SHC1 dbr:Extracellular_signal-regulated_kinases dbr:Transmembrane_receptor |
| dbp:wikiPageUsesTemplate | dbt:Cite_journal dbt:Infobox_gene dbt:MeshName dbt:PDB_Gallery dbt:Refbegin dbt:Refend dbt:Reflist dbt:Short_description dbt:Cytokine_receptor_modulators dbt:Clusters_of_differentiation dbt:Cytokine_receptors |
| dct:subject | dbc:Type_I_cytokine_receptors dbc:Clusters_of_differentiation |
| gold:hypernym | dbr:Protein |
| rdf:type | owl:Thing dbo:Biomolecule dbo:Gene wikidata:Q206229 wikidata:Q7187 yago:WikicatClustersOfDifferentiation yago:Abstraction100002137 yago:Agglomeration107959269 yago:Bunch107959943 yago:Collection107951464 yago:Group100031264 dbo:HumanGene dbo:Protein |
| rdfs:comment | The granulocyte colony-stimulating factor receptor (G-CSF-R) also known as CD114 (Cluster of Differentiation 114) is a protein that in humans is encoded by the CSF3R gene. G-CSF-R is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF). The G-CSF receptors belongs to a family of cytokine receptors known as the hematopoietin receptor family. The granulocyte colony-stimulating factor receptor is present on precursor cells in the bone marrow, and, in response to stimulation by G-CSF, initiates cell proliferation and differentiation into mature neutrophilic granulocytes and macrophages. (en) CSF3R (англ. Colony stimulating factor 3 receptor) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 1-ї хромосоми. Довжина поліпептидного ланцюга білка становить 836 амінокислот, а молекулярна маса — 92 156. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин (uk) |
| rdfs:label | Granulocyte colony-stimulating factor receptor (en) CSF3R (uk) |
| owl:sameAs | freebase:Granulocyte colony-stimulating factor receptor yago-res:Granulocyte colony-stimulating factor receptor wikidata:Granulocyte colony-stimulating factor receptor dbpedia-cy:Granulocyte colony-stimulating factor receptor dbpedia-fa:Granulocyte colony-stimulating factor receptor dbpedia-gl:Granulocyte colony-stimulating factor receptor http://tt.dbpedia.org/resource/CSF3R dbpedia-uk:Granulocyte colony-stimulating factor receptor https://global.dbpedia.org/id/VC5t |
| prov:wasDerivedFrom | wikipedia-en:Granulocyte_colony-stimulating_factor_receptor?oldid=1092816857&ns=0 |
| foaf:isPrimaryTopicOf | wikipedia-en:Granulocyte_colony-stimulating_factor_receptor |
| is dbo:wikiPageRedirects of | dbr:Granulocyte_colony_stimulating_factor_receptor dbr:CSF3R_(gene) dbr:G-CSF-R dbr:G-CSF-receptor dbr:G-CSFR dbr:G-CSF_R dbr:G-CSF_receptor dbr:GCSF-R dbr:CD114 dbr:CSF3R |
| is dbo:wikiPageWikiLink of | dbr:Index_of_biochemistry_articles dbr:Index_of_immunology_articles dbr:Clonal_hypereosinophilia dbr:GRB2 dbr:HCK dbr:Granulocyte_colony-stimulating_factor dbr:Granulocyte_colony_stimulating_factor_receptor dbr:CSF3R_(gene) dbr:P14_deficiency dbr:G-CSF-R dbr:G-CSF-receptor dbr:G-CSFR dbr:G-CSF_R dbr:G-CSF_receptor dbr:GCSF-R dbr:CD114 dbr:CSF3R |
| is foaf:primaryTopic of | wikipedia-en:Granulocyte_colony-stimulating_factor_receptor |