| dbo:abstract |
A growth factor receptor is a receptor that binds to a growth factor. Growth factor receptors are the first stop in cells where the signaling cascade for cell differentiation and proliferation begins. Growth factors, which are ligands that bind to the receptor are the initial step to activating the growth factor receptors and tells the cell to grow and/or divide. These receptors may use the JAK/STAT, MAP kinase, and PI3 kinase pathways. A majority of growth factor receptors consists of receptor tyrosine kinases (RTKs). There are 3 dominant receptor types that are exclusive to research : the epidermal growth factor receptor, the neurotrophin receptor, and the insulin receptors. All growth factor receptors are membrane bound and composed of 3 general protein domains: extracellular, transmembrane, and cytoplasmic. The extracellular domain region is where a ligand may bind, usually with very high specificity. In RTKs, the binding of a ligand to the extracellular ligand binding site leads to the autophosphorylation of tyrosine residues in the intracellular domain. These phosphorylations allow for other intracellular proteins to bind to with the phosphotyrosine-binding domain which results in a series of physiological responses within the cell. (en) 生长因子受体（英語：growth factor receptor）是细胞表面结合生长因子的受体，是生长因子信号在细胞中级联放大的第一步。 作为配體的生长因子与受体结合通常会给与细胞生长或分化的信号。 生长因子受体通常通过JAK/STAT、和PI3激酶等途径起作用。 (zh) |
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dbr:Receptor |
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| rdfs:comment |
生长因子受体（英語：growth factor receptor）是细胞表面结合生长因子的受体，是生长因子信号在细胞中级联放大的第一步。 作为配體的生长因子与受体结合通常会给与细胞生长或分化的信号。 生长因子受体通常通过JAK/STAT、和PI3激酶等途径起作用。 (zh) A growth factor receptor is a receptor that binds to a growth factor. Growth factor receptors are the first stop in cells where the signaling cascade for cell differentiation and proliferation begins. Growth factors, which are ligands that bind to the receptor are the initial step to activating the growth factor receptors and tells the cell to grow and/or divide. These receptors may use the JAK/STAT, MAP kinase, and PI3 kinase pathways. (en) |
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Growth factor receptor (en) 生长因子受体 (zh) |
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