H3R8me2 (original) (raw)

H3R8me2 is an epigenetic modification to the DNA packaging protein histone H3. It is a mark that indicates the di-methylation at the 8th arginine residue of the histone H3 protein. In epigenetics, arginine methylation of histones H3 and H4 is associated with a more accessible chromatin structure and thus higher levels of transcription. The existence of arginine demethylases that could reverse arginine methylation is controversial. H3R8me2 is associated with transcriptional repression, and modified by PRMT5, but not CARM1. As of March 2021, there are no disease associations known for H3R8me2.