H3T6P (original) (raw)

H3T6P is an epigenetic modification to the DNA packaging protein histone H3. It is a mark that indicates the phosphorylation of the 6th threonine residue of the histone H3 protein. H3S10P and H3T6P levels are higher in cervical cancer cells and are responsible for cellular transformation. The writing of H3T6P by androgen-dependent kinase signaling precludes the removal of active methyl tags from H3K4 during AR-stimulated gene expression. H3T6P levels are positively correlated with high Gleason scores in prostate carcinomas.