HAMP domain (original) (raw)
In molecular biology, the HAMP domain (present in Histidine kinases, Adenylate cyclases, Methyl accepting proteins and Phosphatases) is an approximately 50-amino acid alpha-helical region that forms a dimeric, four-helical coiled coil. It is found in bacterial sensor and chemotaxis proteins and in eukaryotic . The bacterial proteins are usually integral membrane proteins and part of a two-component signal transduction pathway. One or several copies of the HAMP domain can be found in association with other domains, such as the histidine kinase domain, the bacterial chemotaxis sensory transducer domain, the PAS repeat, the EAL domain, the GGDEF domain, the protein phosphatase 2C-like domain, the guanylate cyclase domain, or the response regulatory domain. In its most common setting, the HAMP
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| dbo:abstract | In molecular biology, the HAMP domain (present in Histidine kinases, Adenylate cyclases, Methyl accepting proteins and Phosphatases) is an approximately 50-amino acid alpha-helical region that forms a dimeric, four-helical coiled coil. It is found in bacterial sensor and chemotaxis proteins and in eukaryotic . The bacterial proteins are usually integral membrane proteins and part of a two-component signal transduction pathway. One or several copies of the HAMP domain can be found in association with other domains, such as the histidine kinase domain, the bacterial chemotaxis sensory transducer domain, the PAS repeat, the EAL domain, the GGDEF domain, the protein phosphatase 2C-like domain, the guanylate cyclase domain, or the response regulatory domain. In its most common setting, the HAMP domain transmits conformational changes in periplasmic ligand-binding domains to cytoplasmic signalling kinase and methyl-acceptor domains and thus regulates the phosphorylation or methylation activity of homodimeric receptors. (en) |
| dbo:symbol | HAMP |
| dbo:wikiPageID | 35844937 (xsd:integer) |
| dbo:wikiPageLength | 2961 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1032315736 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Methylation dbr:Cytoplasm dbr:EAL_domain dbr:Integral_membrane_protein dbr:Ligand_(biochemistry) dbc:Protein_families dbr:Chemotaxis dbr:Gene_regulation dbr:Conformational_change dbr:GGDEF_domain dbr:Alpha_helix dbr:PAS_domain dbr:Protein_domain dbr:Receptor_(biochemistry) dbr:Guanylate_cyclase dbr:Histidine_kinase dbr:Adenylate_cyclase dbr:Coiled_coil dbr:Methyl-accepting_chemotaxis_protein dbr:Cell_signalling dbr:Molecular_biology dbr:Phosphatase dbr:Phosphorylation dbr:Two-component_regulatory_system dbr:Histidine_kinases |
| dbp:caption | The solution structure of the HAMP domain of the hypothetical transmembrane receptor Af1503 (en) |
| dbp:cdd | cd06225 (en) |
| dbp:interpro | IPR003660 (en) |
| dbp:name | HAMP (en) |
| dbp:opmProtein | 5 (xsd:integer) |
| dbp:pfam | PF00672 (en) |
| dbp:scop | 2 (xsd:integer) |
| dbp:symbol | HAMP (en) |
| dbp:wikiPageUsesTemplate | dbt:Infobox_protein_family dbt:InterPro_content dbt:More_footnotes dbt:Reflist |
| dcterms:subject | dbc:Protein_families |
| rdf:type | owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 yago:Abstraction100002137 yago:Family108078020 yago:Group100031264 yago:Organization108008335 yago:YagoLegalActor yago:YagoLegalActorGeo yago:YagoPermanentlyLocatedEntity dbo:Protein yago:SocialGroup107950920 yago:Unit108189659 yago:WikicatProteinFamilies |
| rdfs:comment | In molecular biology, the HAMP domain (present in Histidine kinases, Adenylate cyclases, Methyl accepting proteins and Phosphatases) is an approximately 50-amino acid alpha-helical region that forms a dimeric, four-helical coiled coil. It is found in bacterial sensor and chemotaxis proteins and in eukaryotic . The bacterial proteins are usually integral membrane proteins and part of a two-component signal transduction pathway. One or several copies of the HAMP domain can be found in association with other domains, such as the histidine kinase domain, the bacterial chemotaxis sensory transducer domain, the PAS repeat, the EAL domain, the GGDEF domain, the protein phosphatase 2C-like domain, the guanylate cyclase domain, or the response regulatory domain. In its most common setting, the HAMP (en) |
| rdfs:label | HAMP domain (en) |
| owl:sameAs | freebase:HAMP domain yago-res:HAMP domain wikidata:HAMP domain https://global.dbpedia.org/id/2LF3s |
| prov:wasDerivedFrom | wikipedia-en:HAMP_domain?oldid=1032315736&ns=0 |
| foaf:isPrimaryTopicOf | wikipedia-en:HAMP_domain |
| is dbo:wikiPageWikiLink of | dbr:TP53-inducible_glycolysis_and_apoptosis_regulator |
| is foaf:primaryTopic of | wikipedia-en:HAMP_domain |