HCV genotypes (original) (raw)
Hepatitis C virus (HCV) genotypes refer to the genetic variations that occurs in the hepatitis C virus. Hepatitis C is a contagious disease that primarily affects the liver, causing severe damage as the disease progresses. It is caused by the Hepatitis C virus, a small, enveloped RNA virus. The transmission of hepatitis C is through the contact with the blood of the infected person, for example by sharing the needles or by using non-sterile medical equipment. HCV is transmitted globally because of the high infection rate and is also associated with a high mortality rate. The World Health Organization indicates the 3.3% of the world population is infected by the HCV virus. Statistical records show that there are about 13 million HCV affected persons in Сhina, 3.5 million affected persons in
| Property | Value |
|---|---|
| dbo:abstract | Hepatitis C virus (HCV) genotypes refer to the genetic variations that occurs in the hepatitis C virus. Hepatitis C is a contagious disease that primarily affects the liver, causing severe damage as the disease progresses. It is caused by the Hepatitis C virus, a small, enveloped RNA virus. The transmission of hepatitis C is through the contact with the blood of the infected person, for example by sharing the needles or by using non-sterile medical equipment. HCV is transmitted globally because of the high infection rate and is also associated with a high mortality rate. The World Health Organization indicates the 3.3% of the world population is infected by the HCV virus. Statistical records show that there are about 13 million HCV affected persons in Сhina, 3.5 million affected persons in the United States, and about 10 million people are affected by HCV in Pakistan. In all cases, the viral genotype of the HCV stays the same, occasionally mutations do occur making the treatment more complex by targeting the changes in the genotype. Hepatitis C virus genotype is considered more common than the Hepatitis B virus infection contributing to more than a million cases annually and is considered one of the major reason for liver transplantation in United States. Some of the HCV genotypes may develop in people without symptoms leading to dangerous conditions like liver cirrhosis causing a permanent damage to liver and the unnoticed HCV conditions will affect brain, joints, blood vessels, bones, and kidneys. The complexity of the HCV genotypes made the treatment specific for the associated genotype. The treatment for the HCV genotype also depends on the presence or absence of cirrhosis. There are six major genotypes of hepatitis C virus which includes many subtypes. The genotype can affect treatment of HCV infections. Recent studies show that HCV genotypes consist of 8 genotypes and 67 subtypes. All the genotypes and subtypes affect the liver to the same extent of damage irrespective of the HCV genotype Among the common six genotypes, genotype 1 is the most prevalent form in the United States of America, covering around 70-90% of total infections. It is usually difficult to treat the people with HCV genotype 1. Genotype 2 and genotype 3 are less common contributing to around 10-20%. Genotypes 4 and 5 affect a large proportion of the population in undeveloped countries. Genotype 4 is the most common type of infections in Middle East and Africa, around 80% of total infections. About 15% of the people affected by HCV genotypes will get cured without medications, in which immune system plays a vital role in defeating the virus. Until recently, there were no specific vaccines available for treating hepatitis C virus genotypes. (en) Вирус гепатита C подразделяется на 8 генотипов, а те, в свою очередь, на свыше 100 подтипов.Генотипы вируса гепатита С различаются между собой по вариабельности нуклеотидного уровня более чем на 30%; подтипы внутри генотипа вируса вариабельны между собой примерно на 15%. Все генотипы вируса способны приводить к циррозу и гепатоцеллюлярной карциноме, однако генотип 3 является фактором более быстрого прогрессирования заболевания. Географически наиболее распространены генотипы 1—4. В Северной Америке и Западной Европе наиболее распространён подтип 1a, охватывающий до 70% всех случаев. В Центральной и Восточной Европе наиболее распространён подтип 1b. На просторах бывшего СССР наибольшее распространение получили подтип 1b и генотип 3.Генотип 4 наиболее распространён на Ближнем Востоке и Африке: в Египте на него приходится до 90% всех инфекций. Наиболее сложны в лечении подтип 1a и генотип 3. Из-за большого генетического разнообразия генотипа 2, часто вступающего в рекомбинанты с другими генотипами, встречаются отдельные штаммы генотипа 2, более устойчивые к терапии. Самым проработанным для лечения является подтип 1b. Согласно проведённому эволюционному анализу, ближайший общий предок вируса генотипа 3a существовал приблизительно 200 лет назад. (ru) |
| dbo:wikiPageID | 52926946 (xsd:integer) |
| dbo:wikiPageLength | 8433 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1123822809 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Mortality_rate dbr:United_States dbr:ELISA dbr:Cirrhosis dbr:Africa dbr:Real-time_polymerase_chain_reaction dbr:Hepatitis_C dbc:Hepatitis_C dbr:Hepatitis_C_virus dbr:Middle_East dbr:World_population |
| dbp:wikiPageUsesTemplate | dbt:Citation_needed dbt:Reflist |
| dcterms:subject | dbc:Hepatitis_C |
| rdfs:comment | Hepatitis C virus (HCV) genotypes refer to the genetic variations that occurs in the hepatitis C virus. Hepatitis C is a contagious disease that primarily affects the liver, causing severe damage as the disease progresses. It is caused by the Hepatitis C virus, a small, enveloped RNA virus. The transmission of hepatitis C is through the contact with the blood of the infected person, for example by sharing the needles or by using non-sterile medical equipment. HCV is transmitted globally because of the high infection rate and is also associated with a high mortality rate. The World Health Organization indicates the 3.3% of the world population is infected by the HCV virus. Statistical records show that there are about 13 million HCV affected persons in Сhina, 3.5 million affected persons in (en) Вирус гепатита C подразделяется на 8 генотипов, а те, в свою очередь, на свыше 100 подтипов.Генотипы вируса гепатита С различаются между собой по вариабельности нуклеотидного уровня более чем на 30%; подтипы внутри генотипа вируса вариабельны между собой примерно на 15%. Все генотипы вируса способны приводить к циррозу и гепатоцеллюлярной карциноме, однако генотип 3 является фактором более быстрого прогрессирования заболевания. Самым проработанным для лечения является подтип 1b. (ru) |
| rdfs:label | HCV genotypes (en) Генотипы вируса гепатита C (ru) |
| owl:sameAs | wikidata:HCV genotypes dbpedia-ru:HCV genotypes https://global.dbpedia.org/id/2iszt |
| prov:wasDerivedFrom | wikipedia-en:HCV_genotypes?oldid=1123822809&ns=0 |
| foaf:isPrimaryTopicOf | wikipedia-en:HCV_genotypes |
| is dbo:wikiPageWikiLink of | dbr:Gamal_Esmat dbr:Grazoprevir dbr:Mylab_Discovery_Solutions dbr:Sunil_Solomon |
| is foaf:primaryTopic of | wikipedia-en:HCV_genotypes |