HLA-DQ4 (original) (raw)
HLA-DQ4 (DQ4) is a serotype subgroup within HLA-DQ(DQ) serotypes. The serotype is determined by the antibody recognition of β4 subset of DQ β-chains. The β-chain of DQ is encoded by HLA-DQB1 locus and DQ4 are encoded by the HLA-DQB1*04 allele group. This group currently contains 2 common alleles, DQB1*0401 and DQB1*0402. HLA-DQ4 and HLA-DQB1*04 are almost synonymous in meaning. DQ4 β-chains combine with α-chains, encoded by genetically linked HLA-DQA1 alleles, to form the cis-haplotype isoforms. These isoforms, nicknamed DQ4.3 and DQ4.4, are also encoded by the DQA1*0303 and DQA1*0401 genes, respectively.
| Property | Value |
|---|---|
| dbo:abstract | HLA-DQ4 (DQ4) is a serotype subgroup within HLA-DQ(DQ) serotypes. The serotype is determined by the antibody recognition of β4 subset of DQ β-chains. The β-chain of DQ is encoded by HLA-DQB1 locus and DQ4 are encoded by the HLA-DQB1*04 allele group. This group currently contains 2 common alleles, DQB1*0401 and DQB1*0402. HLA-DQ4 and HLA-DQB1*04 are almost synonymous in meaning. DQ4 β-chains combine with α-chains, encoded by genetically linked HLA-DQA1 alleles, to form the cis-haplotype isoforms. These isoforms, nicknamed DQ4.3 and DQ4.4, are also encoded by the DQA1*0303 and DQA1*0401 genes, respectively. (en) |
| dbo:thumbnail | wiki-commons:Special:FilePath/DQ_Illustration.png?width=300 |
| dbo:wikiPageID | 12824453 (xsd:integer) |
| dbo:wikiPageLength | 20229 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1116878198 (xsd:integer) |
| dbo:wikiPageWikiLink | dbc:MHC_class_II dbr:Botswana dbr:Ryukyu_Islands dbc:HLA-DQ_haplotypes dbr:Namibia dbr:Andes dbr:Haemophilia_A dbr:Diabetes_mellitus_type_1 dbr:HLA-DQ dbr:HLA-DQB1 dbr:Juvenile_idiopathic_arthritis dbr:Vogt–Koyanagi–Harada_disease dbr:Japan dbr:Chlamydia_infection dbr:High-altitude_pulmonary_edema dbr:Thyroid_cancer dbr:Indonesia dbr:Mexico dbr:MHC_Class_II dbr:Serotype dbr:HLA-DQA1 dbr:Juvenile_diabetes dbr:Wikt:haplotype dbr:Wikt:cis |
| dbp:allele1b | [[#DQB1*0401 (en) |
| dbp:allele2a | *0303 (en) |
| dbp:allele2b | [[#DQB1*0402 (en) |
| dbp:allele3b | *0402 (en) |
| dbp:imageSource | Illustration of HLA-DQ with gliadin peptide in the binding pocket. (en) |
| dbp:isoform | DQ α3β4.1 (en) DQ α3β4.2 (en) DQ α4β4.2 (en) |
| dbp:isoformcount | 3 (xsd:integer) |
| dbp:isoformgroup | HLA-DQ4 (en) |
| dbp:nick | DQ4.3b (en) [[#DQ4.2 (en) [[#DQ4.3 (en) |
| dbp:polymerType | MHC Class II, DQ cell surface antigen (en) |
| dbp:subunit | dbr:HLA-DQB1 dbr:HLA-DQA1 |
| dbp:wikiPageUsesTemplate | dbt:Color dbt:Reflist dbt:HQAA dbt:HQBA dbt:DQ_serotypes dbt:Infobox_heteroisoform |
| dcterms:subject | dbc:MHC_class_II dbc:HLA-DQ_haplotypes |
| gold:hypernym | dbr:Subgroup |
| rdf:type | yago:Abstraction100002137 yago:Collection107951464 yago:Combination107963711 yago:Group100031264 yago:Haplotype105439582 yago:WikicatHLA-DQHaplotypes dbo:EthnicGroup |
| rdfs:comment | HLA-DQ4 (DQ4) is a serotype subgroup within HLA-DQ(DQ) serotypes. The serotype is determined by the antibody recognition of β4 subset of DQ β-chains. The β-chain of DQ is encoded by HLA-DQB1 locus and DQ4 are encoded by the HLA-DQB1*04 allele group. This group currently contains 2 common alleles, DQB1*0401 and DQB1*0402. HLA-DQ4 and HLA-DQB1*04 are almost synonymous in meaning. DQ4 β-chains combine with α-chains, encoded by genetically linked HLA-DQA1 alleles, to form the cis-haplotype isoforms. These isoforms, nicknamed DQ4.3 and DQ4.4, are also encoded by the DQA1*0303 and DQA1*0401 genes, respectively. (en) |
| rdfs:label | HLA-DQ4 (en) |
| owl:sameAs | freebase:HLA-DQ4 yago-res:HLA-DQ4 wikidata:HLA-DQ4 https://global.dbpedia.org/id/4kdXT |
| prov:wasDerivedFrom | wikipedia-en:HLA-DQ4?oldid=1116878198&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/DQ_Illustration.png |
| foaf:isPrimaryTopicOf | wikipedia-en:HLA-DQ4 |
| is dbo:wikiPageWikiLink of | dbr:Major_histocompatibility_complex,_class_II,_DQ_alpha_1 dbr:HLA-DQ dbr:HLA-DQB1 dbr:HLA-DR4 dbr:HLA-DR8 dbr:DQ4 |
| is foaf:primaryTopic of | wikipedia-en:HLA-DQ4 |
