HSP90B1 (original) (raw)
Heat shock protein 90kDa beta member 1 (HSP90B1), known also as endoplasmin, gp96, grp94, or ERp99, is a chaperone protein that in humans is encoded by the HSP90B1 gene. HSP90B1 is an HSP90 paralogue that is found in the endoplasmic reticulum. It plays critical roles in folding proteins in the secretory pathway such as Toll-like receptors and integrins. It has been implicated as an essential immune chaperone to regulate both innate and adaptive immunity. Tumor-derived HSP90B1 (vitespen) has entered clinical trials for cancer immunotherapy.
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| dbo:abstract | Heat shock protein 90kDa beta member 1 (HSP90B1), known also as endoplasmin, gp96, grp94, or ERp99, is a chaperone protein that in humans is encoded by the HSP90B1 gene. HSP90B1 is an HSP90 paralogue that is found in the endoplasmic reticulum. It plays critical roles in folding proteins in the secretory pathway such as Toll-like receptors and integrins. It has been implicated as an essential immune chaperone to regulate both innate and adaptive immunity. Tumor-derived HSP90B1 (vitespen) has entered clinical trials for cancer immunotherapy. grp94 has been shown to be a target for treatment of a plethora of diseases such as glaucoma, multiple myeloma, and metastatic cancer. grp94 includes 5 distinct amino acids in its primary sequence which creates 2 unique sub-pockets, S1 and S2. These sub-pockets have been utilized in current research in order to inhibit the chaperone since its client proteins seem to be up-regulated in cancer cells. (en) HSP90B1 (англ. Heat shock protein 90 beta family member 1) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 12-ї хромосоми. Довжина поліпептидного ланцюга білка становить 803 амінокислот, а молекулярна маса — 92 469. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Кодований геном білок за функцією належить до шаперонів. Білок має сайт для зв'язування з АТФ, нуклеотидами, іоном кальцію. Локалізований у ендоплазматичному ретикулумі. (uk) |
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| dbo:wikiPageWikiLink | dbr:Endoplasmic_reticulum dbr:Innate_immunity dbr:Gene dbc:Endoplasmic_reticulum_resident_proteins dbr:Chaperone_protein dbc:Molecular_chaperones dbr:Homology_(biology) dbr:Hsp90 dbr:Cancer_immunotherapy dbr:Toll-like_receptors dbr:Integrins dbr:Adaptive_immunity |
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| dcterms:subject | dbc:Endoplasmic_reticulum_resident_proteins dbc:Molecular_chaperones |
| gold:hypernym | dbr:Protein |
| rdf:type | owl:Thing dbo:Biomolecule dbo:Gene wikidata:Q206229 wikidata:Q7187 dbo:HumanGene dbo:Protein |
| rdfs:comment | Heat shock protein 90kDa beta member 1 (HSP90B1), known also as endoplasmin, gp96, grp94, or ERp99, is a chaperone protein that in humans is encoded by the HSP90B1 gene. HSP90B1 is an HSP90 paralogue that is found in the endoplasmic reticulum. It plays critical roles in folding proteins in the secretory pathway such as Toll-like receptors and integrins. It has been implicated as an essential immune chaperone to regulate both innate and adaptive immunity. Tumor-derived HSP90B1 (vitespen) has entered clinical trials for cancer immunotherapy. (en) HSP90B1 (англ. Heat shock protein 90 beta family member 1) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 12-ї хромосоми. Довжина поліпептидного ланцюга білка становить 803 амінокислот, а молекулярна маса — 92 469. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин (uk) |
| rdfs:label | HSP90B1 (en) HSP90B1 (uk) |
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| is dbo:wikiPageWikiLink of | dbr:HSP90AB1 dbr:HSP90B1_(gene) dbr:Apolipoprotein_B dbr:List_of_human_protein-coding_genes_2 dbr:GHKL_domain dbr:Tian_Bo dbr:Heat_shock_protein dbr:Glucose-regulated_protein dbr:Grp94 dbr:Baculoviral_IAP_repeat-containing_protein_2 dbr:Hsp90 dbr:HSPPC-96 dbr:SMARCA4 dbr:GRP94 dbr:Gp96 |
| is foaf:primaryTopic of | wikipedia-en:HSP90B1 |