Hemagglutinin-neuraminidase (original) (raw)
Hemagglutinin-neuraminidase refers to a single viral protein that has both hemagglutinin and (endo) neuraminidase EC 3.2.1.18 activity. This is in contrast to the proteins found in influenza, where both functions exist but in two separate proteins. Its neuraminidase domain has the CAZy designation glycoside hydrolase family 83 (GH83). It does show a structural similarity to influenza viral neuraminidase and has a six-bladed beta-propeller structure. This Pfam entry also matches measles hemagglutinin (cd15467), which has a "dead" neuraminidase part repurposed as a receptor binding site.
| Property | Value |
|---|---|
| dbo:abstract | Hemagglutinin-neuraminidase refers to a single viral protein that has both hemagglutinin and (endo) neuraminidase EC 3.2.1.18 activity. This is in contrast to the proteins found in influenza, where both functions exist but in two separate proteins. Its neuraminidase domain has the CAZy designation glycoside hydrolase family 83 (GH83). It does show a structural similarity to influenza viral neuraminidase and has a six-bladed beta-propeller structure. This Pfam entry also matches measles hemagglutinin (cd15467), which has a "dead" neuraminidase part repurposed as a receptor binding site. Hemagglutinin-neuraminidase allows the virus to stick to a potential host cell, and cut itself loose if necessary. Hemagglutinin-neuraminidase can be found in a variety of paramyxoviruses including mumps virus, human parainfluenza virus 3, and the avian pathogen Newcastle disease virus. Types include: * Mumps hemagglutinin-neuraminidase * Parainfluenza hemagglutinin-neuraminidase Hemagglutinin-neuraminidase inhibitors have been investigated and suggest that there may applications for human use in the future. (en) Une hémagglutinine-neuraminidase est une protéine virale présentant à la fois les propriétés d'une hémagglutinine et l'activité enzymatique EC 3.2.1.18 d'une neuraminidase, par opposition aux virus de la grippe chez lesquels ces deux propriétés sont présentes chacune sur une protéine distincte. Le domaine neuraminidase a la désignation CAZy de la famille 83 des glycoside hydrolases (GH83). Ces protéines ne présentent pas de similitude structurelle particulière avec la neuraminidase virale des virus de la grippe et présentent une structure beta-propeller à six lames. Les hémagglutinine-neuraminidases permettent aux virus d'adhérer à la surface de la cellule hôte potentielle. On les retrouve dans tout un ensemble de paramyxovirus tels que le virus des oreillons, le virus Parainfluenza 3 et le virus de la maladie de Newcastle. Certains inhibiteurs de l'hémagglutinine-neuraminidase pourraient avoir des applications chez l'homme. (fr) |
| dbo:symbol | HN |
| dbo:thumbnail | wiki-commons:Special:FilePath/PDB_1usr_EBI.jpg?width=300 |
| dbo:wikiPageID | 20964133 (xsd:integer) |
| dbo:wikiPageLength | 3753 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1032283362 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Newcastle_disease_virus dbr:Beta-propeller dbr:Viral_neuraminidase dbr:Viral_protein dbc:EC_3.2.1 dbc:Protein_families dbr:Paramyxoviridae dbr:Glycoside_hydrolase dbr:Hemagglutinin dbc:GH_family dbr:Influenza dbr:Neuraminidase dbr:Mumps_hemagglutinin-neuraminidase dbr:Mumps_virus dbr:Parainfluenza_hemagglutinin-neuraminidase dbr:Human_parainfluenza_virus |
| dbp:caption | Structure of the sialic acid binding site in Newcastle disease virus hemagglutinin-neuraminidase. (en) |
| dbp:cazy | GH83 (en) |
| dbp:cdd | cd15469 (en) |
| dbp:interpro | IPR000665 (en) |
| dbp:name | Hemagglutinin-neuraminidase, Paramyxoviridae (en) |
| dbp:pdb | , , , , , , , , , (en) |
| dbp:pfam | PF00423 (en) |
| dbp:pfamClan | CL0434 (en) |
| dbp:scop | 1 (xsd:integer) |
| dbp:symbol | HN (en) |
| dbp:wikiPageUsesTemplate | dbt:EC_number dbt:Enzymes dbt:Infobox_protein_family dbt:Portal_bar dbt:Reflist dbt:Sugar_hydrolases dbt:PDB2 dbt:Viral_proteins |
| dcterms:subject | dbc:EC_3.2.1 dbc:Protein_families dbc:GH_family |
| rdf:type | owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 yago:Abstraction100002137 yago:Family108078020 yago:Group100031264 yago:Organization108008335 yago:YagoLegalActor yago:YagoLegalActorGeo yago:YagoPermanentlyLocatedEntity dbo:Protein yago:SocialGroup107950920 yago:Unit108189659 |
| rdfs:comment | Hemagglutinin-neuraminidase refers to a single viral protein that has both hemagglutinin and (endo) neuraminidase EC 3.2.1.18 activity. This is in contrast to the proteins found in influenza, where both functions exist but in two separate proteins. Its neuraminidase domain has the CAZy designation glycoside hydrolase family 83 (GH83). It does show a structural similarity to influenza viral neuraminidase and has a six-bladed beta-propeller structure. This Pfam entry also matches measles hemagglutinin (cd15467), which has a "dead" neuraminidase part repurposed as a receptor binding site. (en) Une hémagglutinine-neuraminidase est une protéine virale présentant à la fois les propriétés d'une hémagglutinine et l'activité enzymatique EC 3.2.1.18 d'une neuraminidase, par opposition aux virus de la grippe chez lesquels ces deux propriétés sont présentes chacune sur une protéine distincte. Le domaine neuraminidase a la désignation CAZy de la famille 83 des glycoside hydrolases (GH83). Ces protéines ne présentent pas de similitude structurelle particulière avec la neuraminidase virale des virus de la grippe et présentent une structure beta-propeller à six lames. (fr) |
| rdfs:label | Hemagglutinin-neuraminidase (en) Hémagglutinine-neuraminidase (fr) |
| owl:sameAs | freebase:Hemagglutinin-neuraminidase wikidata:Hemagglutinin-neuraminidase dbpedia-fr:Hemagglutinin-neuraminidase https://global.dbpedia.org/id/KB4q |
| prov:wasDerivedFrom | wikipedia-en:Hemagglutinin-neuraminidase?oldid=1032283362&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/PDB_1usr_EBI.jpg |
| foaf:isPrimaryTopicOf | wikipedia-en:Hemagglutinin-neuraminidase |
| is dbo:wikiPageRedirects of | dbr:Glycoside_hydrolase_family_83 |
| is dbo:wikiPageWikiLink of | dbr:Viral_neuraminidase dbr:Index_of_oncology_articles dbr:Paramyxoviridae dbr:Murine_respirovirus dbr:Glycoside_hydrolase_family_83 dbr:Hemagglutinin dbr:Measles_hemagglutinin dbr:Mumps_virus dbr:Syncytium dbr:Parainfluenza_hemagglutinin-neuraminidase |
| is gold:hypernym of | dbr:Mumps_hemagglutinin-neuraminidase dbr:Parainfluenza_hemagglutinin-neuraminidase |
| is foaf:primaryTopic of | wikipedia-en:Hemagglutinin-neuraminidase |
