Human Proteome Folding Project (original) (raw)
Il progetto Human Proteome Folding (HPF) è frutto della collaborazione tra l'Università di New York (Bonneau Lab), l' (ISB) e l'Università di Washington (Baker Lab), utilizzando il software Rosetta sviluppato da .Il progetto HPF è attualmente alla fase 2, che lavora esclusivamente sul progetto di calcolo distribuito World Community Grid. La fase 1 ha lavorato su due reti di calcolo distribuito: World Community Grid, un'iniziativa filantropica dell'IBM, e la United Devices' grid.org.L'Institute for Systems Biology ha progettato lo Human Proteome Folding per il World Community Grid e userà i risultati nel suo più ampio impegno di ricerca.
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| dbo:abstract | El Human Proteome Folding Project (HPF, «Projecte de Plegament del Proteoma Humà») és un projecte col·laboratiu de la Universitat de Nova York (Laboratori ), l' (ISB) i la Universitat de Washington (Laboratori Baker), que utilitza el programari Rosetta desenvolupat per Rosetta Commons. El projecte HPF es troba actualment a la Fase 2, que funciona exclusivament a la World Community Grid. La Fase 1 funcionava a dues xarxes de computació distribuïda: la World Community Grid, una iniciativa filantròpica d'IBM i la de . L'Institute for Systems Biology dissenyà el Human Proteome Folding Project per a la World Community Grid i n'utilitzarà els resultats en els seus programes de recerca. (ca) Das Human Proteome Folding Project war ein Projekt des World Community Grid für verteiltes Rechnen. Betrieben wurde das Projekt von der New York University, dem in Seattle und der University of Washington. Ziel dieses Projekts war die de novo-Strukturvorhersage menschlicher Proteine. Als Algorithmus findet die Software des Rosetta@home-Projekts Anwendung, die aufgrund sehr guter Ergebnisse bei dem CASP-Wettbewerb als sehr leistungsfähig gilt. Das Projekt wurde in zwei Phasen durchgeführt bei denen medizinisch besonders wichtige Proteine genauer untersucht werden. Am 10. Juli 2007 wurde bekannt, dass der erste Malaria-relevante Datensatz an Proteinen erfolgreich berechnet wurde. Das Projekt basiert auf der BOINC-Infrastruktur. Früher wurde ein eigener Client eingesetzt, der allerdings eingestellt wurde. Die Infrastruktur des Projekts wurde von IBM gesponsert, es handelt sich allerdings nicht um ein kommerzielles Projekt, da alle Ergebnisse auch öffentlich zugänglich sind. (de) El Proyecto del Plegado del Proteoma Humano, en inglés Human Proteome Folding Project (HPF), es un esfuerzo colaborativo entre la Universidad de Nueva York (laboratorio Bonneau), el Instituto de Biología de Sistemas (Institute for Systems Biology, ISB) de Washington, y la Universidad de Washington (laboratorio Baker), dedicado a la investigación de la forma que adoptan las proteínas humanas, y que utiliza el software Rosetta desarrollado por Rosetta Commons). El proyecto está actualmente en Fase 2, y corriendo exclusivamente en la World Community Grid. La Fase 1 corrió sobre dos redes de computación distribuida: la World Community Grid (una iniciativa filantrópica de IBM), y sobre el de la compañía United Devices. (es) The Human Proteome Folding Project (HPF) is a collaborative effort between New York University (Bonneau Lab), the Institute for Systems Biology (ISB) and the University of Washington (Baker Lab), using the Rosetta software developed by the Rosetta Commons. HPF Phase 1 applied Rosetta v4.2x software on the human genome and 89 others, starting in November 2004. Phase 1 ended in July 2006. HPF Phase 2 (HPF2) applies the Rosetta v4.8x software in higher resolution, "full atom refinement" mode, concentrating on cancer biomarkers (proteins found at dramatically increased levels in cancer tissues), human secreted proteins and malaria. Phase 1 ran on two volunteer computing grids: on United Devices' grid.org, and on the World Community Grid, an IBM philanthropic initiative. Phase 2 of the project ran exclusively on the World Community Grid; it terminated in 2013 after more than 9 years of IBM involvement. The Institute for Systems Biology will use the results of the computations within its larger research efforts. (en) Il progetto Human Proteome Folding (HPF) è frutto della collaborazione tra l'Università di New York (Bonneau Lab), l' (ISB) e l'Università di Washington (Baker Lab), utilizzando il software Rosetta sviluppato da .Il progetto HPF è attualmente alla fase 2, che lavora esclusivamente sul progetto di calcolo distribuito World Community Grid. La fase 1 ha lavorato su due reti di calcolo distribuito: World Community Grid, un'iniziativa filantropica dell'IBM, e la United Devices' grid.org.L'Institute for Systems Biology ha progettato lo Human Proteome Folding per il World Community Grid e userà i risultati nel suo più ampio impegno di ricerca. (it) |
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| rdfs:comment | Il progetto Human Proteome Folding (HPF) è frutto della collaborazione tra l'Università di New York (Bonneau Lab), l' (ISB) e l'Università di Washington (Baker Lab), utilizzando il software Rosetta sviluppato da .Il progetto HPF è attualmente alla fase 2, che lavora esclusivamente sul progetto di calcolo distribuito World Community Grid. La fase 1 ha lavorato su due reti di calcolo distribuito: World Community Grid, un'iniziativa filantropica dell'IBM, e la United Devices' grid.org.L'Institute for Systems Biology ha progettato lo Human Proteome Folding per il World Community Grid e userà i risultati nel suo più ampio impegno di ricerca. (it) El Human Proteome Folding Project (HPF, «Projecte de Plegament del Proteoma Humà») és un projecte col·laboratiu de la Universitat de Nova York (Laboratori ), l' (ISB) i la Universitat de Washington (Laboratori Baker), que utilitza el programari Rosetta desenvolupat per Rosetta Commons. El projecte HPF es troba actualment a la Fase 2, que funciona exclusivament a la World Community Grid. La Fase 1 funcionava a dues xarxes de computació distribuïda: la World Community Grid, una iniciativa filantròpica d'IBM i la de . (ca) Das Human Proteome Folding Project war ein Projekt des World Community Grid für verteiltes Rechnen. Betrieben wurde das Projekt von der New York University, dem in Seattle und der University of Washington. Ziel dieses Projekts war die de novo-Strukturvorhersage menschlicher Proteine. Als Algorithmus findet die Software des Rosetta@home-Projekts Anwendung, die aufgrund sehr guter Ergebnisse bei dem CASP-Wettbewerb als sehr leistungsfähig gilt. Das Projekt wurde in zwei Phasen durchgeführt bei denen medizinisch besonders wichtige Proteine genauer untersucht werden. (de) The Human Proteome Folding Project (HPF) is a collaborative effort between New York University (Bonneau Lab), the Institute for Systems Biology (ISB) and the University of Washington (Baker Lab), using the Rosetta software developed by the Rosetta Commons. Phase 1 ran on two volunteer computing grids: on United Devices' grid.org, and on the World Community Grid, an IBM philanthropic initiative. Phase 2 of the project ran exclusively on the World Community Grid; it terminated in 2013 after more than 9 years of IBM involvement. (en) El Proyecto del Plegado del Proteoma Humano, en inglés Human Proteome Folding Project (HPF), es un esfuerzo colaborativo entre la Universidad de Nueva York (laboratorio Bonneau), el Instituto de Biología de Sistemas (Institute for Systems Biology, ISB) de Washington, y la Universidad de Washington (laboratorio Baker), dedicado a la investigación de la forma que adoptan las proteínas humanas, y que utiliza el software Rosetta desarrollado por Rosetta Commons). (es) |
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