| dbo:abstract |
Hydroxynorketamin (HNK) ist ein Metabolit von Ketamin, welches durch Hydroxylierung seines Metaboliten Norketamin gebildet wird. Im Gegensatz zu Ketamin und Norketamin ist Hydroxynorketamin als Anästhetikum und Dissoziativum inaktiv und produziert keine Rauschzustände. (de) Hydroxynorketamine (HNK), or 6-hydroxynorketamine, is a minor metabolite of the anesthetic, dissociative, and antidepressant drug ketamine. It is formed by hydroxylation of the intermediate norketamine, another metabolite of ketamine. As of late 2019, (2R,6R)-HNK is in clinical trials for the treatment of depression. The major metabolite of ketamine is norketamine (80%). Norketamine is secondarily converted into 4-, 5-, and 6-hydroxynorketamines (15%), mainly HNK (6-hydroxynorketamine). Ketamine is also transformed into hydroxyketamine (5%). As such, bioactivated HNK comprises less than 15% of a dose of ketamine. (en) |
| dbo:casNumber |
81395-70-2 |
| dbo:fdaUniiCode |
6VAD9SC8NW |
| dbo:pubchem |
133669 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/(2R,6R)-Hydroxynorketamine_Formula_V1.svg?width=300 |
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dbr:Psychostimulant dbr:Metabolic_intermediate dbr:Metabolite dbr:Dehydronorketamine dbr:United_States dbr:Depression_(mood) dbr:Ligand_(biochemistry) dbr:List_of_investigational_antidepressants dbc:Acyloins dbc:Chloroarenes dbc:Experimental_drugs dbc:Human_drug_metabolites dbr:Memantine dbr:Nature_(journal) dbc:Nicotinic_antagonists dbr:Antidepressant dbr:Mammalian_target_of_rapamycin dbr:Stereoisomer dbr:Clinical_trial dbr:Receptor_antagonist dbr:Traxoprodil dbr:Drug dbc:Antidepressants dbr:Alpha-7_nicotinic_receptor dbr:Esketamine dbr:Estrogen_receptor dbr:Anesthetic dbr:Norketamine dbc:Arylcyclohexylamines dbr:Hydroxylation dbr:Arketamine dbr:AMPA_receptor dbc:Drugs_with_unknown_mechanisms_of_action dbr:Affinity_(pharmacology) dbr:Ketamine dbr:Lanicemine dbr:Biological_activity dbr:Dissociative_drug dbr:Dizocilpine dbr:National_Institute_of_Mental_Health dbr:IC50 dbr:Phases_of_clinical_research dbr:NMDA_receptor dbr:Forced_swim_test dbr:ERα dbr:Negative_allosteric_modulator |
| dbp:alt |
-Hydroxynorketamine (en) |
| dbp:altl |
-Hydroxynorketamine (en) |
| dbp:altr |
-Hydroxynorketamine (en) |
| dbp:atcPrefix |
None (en) |
| dbp:c |
12 (xsd:integer) |
| dbp:caption |
The four possible stereoisomers of Hydroxynorketamine (en) |
| dbp:casNumber |
81395 (xsd:integer) |
| dbp:chemspiderid |
117907 (xsd:integer) |
| dbp:cl |
1 (xsd:integer) |
| dbp:h |
14 (xsd:integer) |
| dbp:image |
-Hydroxynorketamine Formula V1.svg (en) |
| dbp:imagel |
-Hydroxynorketamine Formula V1.svg (en) |
| dbp:imager |
-Hydroxynorketamine Formula V1.svg (en) |
| dbp:iupacName |
2 (xsd:integer) |
| dbp:n |
1 (xsd:integer) |
| dbp:o |
2 (xsd:integer) |
| dbp:pubchem |
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| dbp:smiles |
C1CCO (en) |
| dbp:stdinchi |
1 (xsd:integer) |
| dbp:stdinchikey |
CFBVGSWSOJBYGC-UHFFFAOYSA-N (en) |
| dbp:synonyms |
HNK; 6-Hydroxynorketamine; 6-HNK (en) |
| dbp:unii |
6 (xsd:integer) |
| dbp:width |
180 (xsd:integer) |
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dbt:Abbr dbt:Drugbox dbt:Estrogen_receptor_modulators dbt:Reflist dbt:Cascite dbt:Fdacite dbt:Nicotinic_acetylcholine_receptor_modulators dbt:Antidepressants |
| dct:subject |
dbc:Acyloins dbc:Chloroarenes dbc:Experimental_drugs dbc:Human_drug_metabolites dbc:Nicotinic_antagonists dbc:Antidepressants dbc:Arylcyclohexylamines dbc:Drugs_with_unknown_mechanisms_of_action |
| gold:hypernym |
dbr:Metabolite |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:ChemicalCompound dbo:Drug |
| rdfs:comment |
Hydroxynorketamin (HNK) ist ein Metabolit von Ketamin, welches durch Hydroxylierung seines Metaboliten Norketamin gebildet wird. Im Gegensatz zu Ketamin und Norketamin ist Hydroxynorketamin als Anästhetikum und Dissoziativum inaktiv und produziert keine Rauschzustände. (de) Hydroxynorketamine (HNK), or 6-hydroxynorketamine, is a minor metabolite of the anesthetic, dissociative, and antidepressant drug ketamine. It is formed by hydroxylation of the intermediate norketamine, another metabolite of ketamine. As of late 2019, (2R,6R)-HNK is in clinical trials for the treatment of depression. (en) |
| rdfs:label |
Hydroxynorketamin (de) Hydroxynorketamine (en) |
| owl:sameAs |
freebase:Hydroxynorketamine yago-res:Hydroxynorketamine wikidata:Hydroxynorketamine dbpedia-de:Hydroxynorketamine https://global.dbpedia.org/id/vA12 |
| prov:wasDerivedFrom |
wikipedia-en:Hydroxynorketamine?oldid=1072423021&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/(2R,6R)-Hydroxynorketamine_Formula_V1.svg wiki-commons:Special:FilePath/(2R,6S)-Hydroxynorketamine_Formula_V1.svg wiki-commons:Special:FilePath/(2S,6R)-Hydroxynorketamine_Formula_V1.svg wiki-commons:Special:FilePath/(2S,6S)-Hydroxynorketamine_Formula_V1.svg |
| foaf:isPrimaryTopicOf |
wikipedia-en:Hydroxynorketamine |
| is dbo:wikiPageDisambiguates of |
dbr:HNK |
| is dbo:wikiPageRedirects of |
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| is dbo:wikiPageWikiLink of |
dbr:Dehydronorketamine dbr:List_of_investigational_antidepressants dbr:Trifluoromethyldeschloroketamine dbr:Alpha-7_nicotinic_receptor dbr:Norketamine dbr:HNK dbr:Arketamine dbr:Ketamine dbr:Arylcyclohexylamine dbr:C12H14ClNO2 dbr:List_of_signaling_peptide/protein_receptor_modulators dbr:6-Hydroxynorketamine dbr:6-hydroxynorketamine dbr:2R,6R-Hydroxynorketamine dbr:2R,6R-hydroxynorketamine dbr:(2R,6R)-Hydroxynorketamine dbr:(2R,6R)-hydroxynorketamine |
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wikipedia-en:Hydroxynorketamine |
-Hydroxynorketamine_Formula_V1.svg?width=300)
