Ibipinabant (original) (raw)
Ibipinabant (SLV319, BMS-646,256) is a drug used in scientific research which acts as a potent and highly selective CB1 antagonist. It has potent anorectic effects in animals, and was researched for the treatment of obesity, although CB1 antagonists as a class have now fallen out of favour as potential anorectics following the problems seen with rimonabant, and so ibipinabant is now only used for laboratory research, especially structure-activity relationship studies into novel CB1 antagonists. SLV330, which is a structural analogue of Ibipinabant, was reported active in animal models related to the regulation of memory, cognition, as well as in addictive behavior. An atom-efficient synthesis of ibipinabant has been reported.
| Property | Value |
|---|---|
| dbo:abstract | Ibipinabant (SLV319, BMS-646,256) is a drug used in scientific research which acts as a potent and highly selective CB1 antagonist. It has potent anorectic effects in animals, and was researched for the treatment of obesity, although CB1 antagonists as a class have now fallen out of favour as potential anorectics following the problems seen with rimonabant, and so ibipinabant is now only used for laboratory research, especially structure-activity relationship studies into novel CB1 antagonists. SLV330, which is a structural analogue of Ibipinabant, was reported active in animal models related to the regulation of memory, cognition, as well as in addictive behavior. An atom-efficient synthesis of ibipinabant has been reported. (en) |
| dbo:casNumber | 464213-10-3 |
| dbo:chEMBL | 158784 |
| dbo:fdaUniiCode | O5CSC6WH1T |
| dbo:kegg | D09349 |
| dbo:pubchem | 9826744 |
| dbo:thumbnail | wiki-commons:Special:FilePath/Ibipinabant.svg?width=300 |
| dbo:wikiPageID | 20247773 (xsd:integer) |
| dbo:wikiPageLength | 7477 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1082424224 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Anorectic dbr:Rimonabant dbc:Abandoned_drugs dbc:Cannabinoids dbc:Chloroarenes dbc:Pyrazolines dbc:CB1_receptor_antagonists dbr:Obesity dbr:Cannabinoid_receptor_antagonist dbr:Cannabinoid_receptor_1 dbr:Structure-activity_relationship dbr:Antagonist_(pharmacology) |
| dbp:atcPrefix | none (en) |
| dbp:c | 24 (xsd:integer) |
| dbp:casNumber | 464213 (xsd:integer) |
| dbp:chembl | 158784 (xsd:integer) |
| dbp:chemspiderid | 24765166 (xsd:integer) |
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| dbp:kegg | D09349 (en) |
| dbp:molecularWeight | 501.427000 (xsd:double) |
| dbp:n | 4 (xsd:integer) |
| dbp:o | 2 (xsd:integer) |
| dbp:pubchem | 9826744 (xsd:integer) |
| dbp:s | 1 (xsd:integer) |
| dbp:smiles | c2ccccc2C1=NNCC1c4ccccc4 (en) |
| dbp:stdinchi | 1 (xsd:integer) |
| dbp:stdinchikey | BSFKAVCGRDMWTK-JOCHJYFZSA-N (en) |
| dbp:unii | O5CSC6WH1T (en) |
| dbp:verifiedfields | changed (en) |
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| dbp:watchedfields | changed (en) |
| dbp:width | 250 (xsd:integer) |
| dbp:wikiPageUsesTemplate | dbt:Cannabinoid-stub dbt:Cannabinoidergics dbt:Cannabinoids dbt:Drugbox dbt:Reflist dbt:Short_description dbt:Cascite dbt:Chemspidercite dbt:Drugbankcite dbt:Ebicite dbt:Fdacite dbt:Keggcite dbt:Stdinchicite dbt:Anorectics |
| dcterms:subject | dbc:Abandoned_drugs dbc:Cannabinoids dbc:Chloroarenes dbc:Pyrazolines dbc:CB1_receptor_antagonists |
| gold:hypernym | dbr:Drug |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatCB1ReceptorAntagonists yago:Adversary109773245 yago:CausalAgent100007347 yago:LivingThing100004258 yago:Object100002684 yago:Organism100004475 yago:Person100007846 yago:PhysicalEntity100001930 yago:YagoLegalActor yago:YagoLegalActorGeo dbo:Drug yago:Whole100003553 umbel-rc:DrugProduct |
| rdfs:comment | Ibipinabant (SLV319, BMS-646,256) is a drug used in scientific research which acts as a potent and highly selective CB1 antagonist. It has potent anorectic effects in animals, and was researched for the treatment of obesity, although CB1 antagonists as a class have now fallen out of favour as potential anorectics following the problems seen with rimonabant, and so ibipinabant is now only used for laboratory research, especially structure-activity relationship studies into novel CB1 antagonists. SLV330, which is a structural analogue of Ibipinabant, was reported active in animal models related to the regulation of memory, cognition, as well as in addictive behavior. An atom-efficient synthesis of ibipinabant has been reported. (en) |
| rdfs:label | Ibipinabant (en) |
| owl:sameAs | freebase:Ibipinabant yago-res:Ibipinabant wikidata:Ibipinabant http://azb.dbpedia.org/resource/ایبیپینابانت dbpedia-fa:Ibipinabant dbpedia-sh:Ibipinabant dbpedia-sr:Ibipinabant https://global.dbpedia.org/id/4nTrF |
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| foaf:depiction | wiki-commons:Special:FilePath/Ibipinabant.svg |
| foaf:isPrimaryTopicOf | wikipedia-en:Ibipinabant |
| is dbo:wikiPageRedirects of | dbr:SLV-319 dbr:SLV319 |
| is dbo:wikiPageWikiLink of | dbr:List_of_psychedelic_drugs dbr:Cannabinoid_receptor_antagonist dbr:Cannabinoid_receptor_type_1 dbr:List_of_drugs:_Ia–Il dbr:SLV-319 dbr:SLV319 |
| is foaf:primaryTopic of | wikipedia-en:Ibipinabant |
