IgA specific serine endopeptidase (original) (raw)
IgA protease (EC 3.4.21.72, IgA-specific serine endopeptidase, IgA proteinase, IgA-specific proteinase, immunoglobulin A protease, immunoglobulin A proteinase) is an enzyme. This enzyme catalyses the following chemical reaction[reaction equation needed] It performs cleavage of immunoglobulin A molecules at certain Pro- bonds in the hinge region. No small molecule substrates are known This enzyme is secreted by Gram-negative bacteria Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilus influenzae, and Gram-positive Streptococcus pneumoniae.
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| dbo:abstract | IgA protease (EC 3.4.21.72, IgA-specific serine endopeptidase, IgA proteinase, IgA-specific proteinase, immunoglobulin A protease, immunoglobulin A proteinase) is an enzyme. This enzyme catalyses the following chemical reaction[reaction equation needed] It performs cleavage of immunoglobulin A molecules at certain Pro- bonds in the hinge region. No small molecule substrates are known This enzyme is secreted by Gram-negative bacteria Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilus influenzae, and Gram-positive Streptococcus pneumoniae. The action of IgA protease allows the above mentioned bacteria to adhere to mucous membranes. An IgA protease is a highly specific 106kDa enzyme that cleaves amino acid sequences of certain proteins. The natural substrate of IgA proteases is immunoglobulin A, hence its name. The enzyme is in fact capable of cleavage of proteins with the amino acid sequence Cleaves N-X-Z-Pro-Pro/-Y-Pro-C, where the X in the sequence preferably is a Proline or Serine; the Y = Threonine, Serine or Alanine; and Z preferably is Arginine or Threonine. Because of the sequence that the enzyme is able to cleave, it is also called IgAse Pro-Pro-Y-Pro. Thus, the IgA protease act by cleaving the proline-rich hinge region of the heavy chain of IgA1. Three major bacteria, Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae type B, release the IgA protease which destroys IgA. (en) |
| dbo:ecNumber | 3.4.21.72 |
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| dbo:wikiPageWikiLink | dbr:Proline dbr:Chemical_reaction dbr:Enzyme dbr:Haemophilus_influenzae dbr:Bacteria dbr:Threonine dbr:Gram-positive dbr:Alanine dbr:Amino_acid dbr:Gram-negative_bacteria dbr:Streptococcus_pneumoniae dbr:Arginine dbc:EC_3.4.21 dbc:Proteases dbr:Catalysis dbr:Serine dbr:Neisseria_gonorrhoeae dbr:Neisseria_meningitidis dbr:Immunoglobulin_A |
| dbp:casNumber | 55127 (xsd:integer) |
| dbp:ecNumber | 3.400000 (xsd:double) |
| dbp:iubmbEcNumber | 3 (xsd:integer) |
| dbp:name | IgA-specific serine endopeptidase (en) |
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| dct:subject | dbc:EC_3.4.21 dbc:Proteases |
| gold:hypernym | dbr:Enzyme |
| rdf:type | owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8047 yago:Abstraction100002137 yago:Activator114723079 yago:Catalyst114723628 yago:Chemical114806838 yago:Compound114818238 yago:Enzyme114732946 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 dbo:Enzyme dbo:Protein yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 |
| rdfs:comment | IgA protease (EC 3.4.21.72, IgA-specific serine endopeptidase, IgA proteinase, IgA-specific proteinase, immunoglobulin A protease, immunoglobulin A proteinase) is an enzyme. This enzyme catalyses the following chemical reaction[reaction equation needed] It performs cleavage of immunoglobulin A molecules at certain Pro- bonds in the hinge region. No small molecule substrates are known This enzyme is secreted by Gram-negative bacteria Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilus influenzae, and Gram-positive Streptococcus pneumoniae. (en) |
| rdfs:label | IgA specific serine endopeptidase (en) |
| owl:sameAs | freebase:IgA specific serine endopeptidase wikidata:IgA specific serine endopeptidase dbpedia-sh:IgA specific serine endopeptidase dbpedia-sr:IgA specific serine endopeptidase https://global.dbpedia.org/id/KuSe |
| prov:wasDerivedFrom | wikipedia-en:IgA_specific_serine_endopeptidase?oldid=1113674254&ns=0 |
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| foaf:name | IgA-specific serine endopeptidase (en) |
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| is dbo:wikiPageWikiLink of | dbr:PA_clan_of_proteases dbr:IgA_protease dbr:Immunoglobulin_A dbr:IgA-specific_serine_endopeptidase |
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