JWH-203 (original) (raw)
JWH-203 – organiczny związek chemiczny, syntetyczny kanabinoid zsyntezowany przez Johna W. Huffmana (stąd akronim JWH). W Polsce od 2011 roku jest w grupie I-N Ustawy o przeciwdziałaniu narkomanii.
| Property | Value |
|---|---|
| dbo:abstract | JWH-203 (1-pentyl-3-(2-chlorophenylacetyl)indole) is an analgesic chemical from the phenylacetylindole family that acts as a cannabinoid agonist with approximately equal affinity at both the CB1 and CB2 receptors, having a Ki of 8.0 nM at CB1 and 7.0 nM at CB2. It was originally discovered by, and named after, John W. Huffman, but has subsequently been sold without his permission as an ingredient of synthetic cannabis smoking blends. Similar to the related 2'-methoxy compound JWH-250, the 2'-bromo compound JWH-249, and the 2'-methyl compound JWH-251, JWH-203 has a phenylacetyl group in place of the naphthoyl ring used in most aminoalkylindole cannabinoid compounds, and has the strongest in vitro binding affinity for the cannabinoid receptors of any compound in the phenylacetyl group. Unexpectedly despite its weaker CB1 Ki in vitro, the 2-methylindole derivative JWH-204 is actually more potent than JWH-203 in animal tests for cannabinoid activity, though it is still weaker than JWH-249. (en) JWH-203 – organiczny związek chemiczny, syntetyczny kanabinoid zsyntezowany przez Johna W. Huffmana (stąd akronim JWH). W Polsce od 2011 roku jest w grupie I-N Ustawy o przeciwdziałaniu narkomanii. (pl) JWH-203 (1-пентил-3-(2-хлорфенилацетил)индол) — анальгетик, , действующий как каннабиноидный агонист с практически равным сродством с CB1 и CB2 рецепторами. Так, ингибиторная константа, показывающая степень сродства к CB1, составляет 8 нМ. Был создан химиком Джоном Хаффманом в экспериментальных целях, откуда и сокращение «JWH». (ru) |
| dbo:casNumber | (JWH-203)864445-55-6 (JWH-204) 864445-54-5 |
| dbo:fdaUniiCode | 52CP80V8FY |
| dbo:pubchem | 44397500 |
| dbo:thumbnail | wiki-commons:Special:FilePath/JWH-203.svg?width=300 |
| dbo:wikiPageID | 26636686 (xsd:integer) |
| dbo:wikiPageLength | 5494 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1106367774 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Alkyl dbr:John_W._Huffman dbr:Methoxy dbr:Cannabinoid_receptor_2_(macrophage) dbr:Schedule_I_Controlled_Substance dbc:Chloroarenes dbc:Designer_drugs dbc:JWH_cannabinoids dbr:Synthetic_cannabis dbr:MN-25 dbr:Bromine dbr:Dissociation_constant dbr:Acetyl dbr:Agonist dbr:Analgesic dbr:Amino dbc:CB1_receptor_agonists dbc:CB2_receptor_agonists dbr:JWH-249 dbr:JWH-250 dbr:JWH-251 dbr:Methyl dbr:Indole dbr:Cannabinoid dbc:Phenylacetylindoles dbr:Phenylacetylindole dbr:Cannabinoid_receptor_1 dbr:Phenyl dbr:Naphthoyl dbr:File:JWH-204.svg |
| dbp:c | 21 (xsd:integer) |
| dbp:casNumber | 864445 (xsd:integer) |
| dbp:casSupplemental | 864445 (xsd:integer) |
| dbp:chemspiderid | 23256082 (xsd:integer) |
| dbp:cl | 1 (xsd:integer) |
| dbp:h | 22 (xsd:integer) |
| dbp:iupacName | 2 (xsd:integer) |
| dbp:legalCa | Schedule II (en) |
| dbp:legalDe | Anlage II (en) |
| dbp:legalStatus | I-N (en) |
| dbp:legalUk | Class B (en) |
| dbp:legalUs | Schedule I (en) |
| dbp:n | 1 (xsd:integer) |
| dbp:o | 1 (xsd:integer) |
| dbp:pubchem | 44397500 (xsd:integer) |
| dbp:smiles | Clc2ccccc2CCc1cnc3ccccc13 (en) |
| dbp:stdinchi | 1 (xsd:integer) |
| dbp:stdinchikey | YDINKDBAZJOSLV-UHFFFAOYSA-N (en) |
| dbp:unii | 52 (xsd:integer) |
| dbp:verifiedrevid | 451554581 (xsd:integer) |
| dbp:width | 150 (xsd:integer) |
| dbp:wikiPageUsesTemplate | dbt:Cannabinoids dbt:Clear_left dbt:Drugbox dbt:Reflist dbt:Short_description dbt:Use_dmy_dates dbt:Cascite dbt:Fdacite |
| dcterms:subject | dbc:Chloroarenes dbc:Designer_drugs dbc:JWH_cannabinoids dbc:CB1_receptor_agonists dbc:CB2_receptor_agonists dbc:Phenylacetylindoles |
| gold:hypernym | dbr:Chemical |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatAromaticKetones yago:Abstraction100002137 yago:Chemical114806838 yago:Compound114818238 yago:Ketone114926294 yago:Material114580897 yago:Matter100020827 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Relation100031921 dbo:ChemicalCompound dbo:Drug yago:Substance100019613 |
| rdfs:comment | JWH-203 – organiczny związek chemiczny, syntetyczny kanabinoid zsyntezowany przez Johna W. Huffmana (stąd akronim JWH). W Polsce od 2011 roku jest w grupie I-N Ustawy o przeciwdziałaniu narkomanii. (pl) JWH-203 (1-пентил-3-(2-хлорфенилацетил)индол) — анальгетик, , действующий как каннабиноидный агонист с практически равным сродством с CB1 и CB2 рецепторами. Так, ингибиторная константа, показывающая степень сродства к CB1, составляет 8 нМ. Был создан химиком Джоном Хаффманом в экспериментальных целях, откуда и сокращение «JWH». (ru) JWH-203 (1-pentyl-3-(2-chlorophenylacetyl)indole) is an analgesic chemical from the phenylacetylindole family that acts as a cannabinoid agonist with approximately equal affinity at both the CB1 and CB2 receptors, having a Ki of 8.0 nM at CB1 and 7.0 nM at CB2. It was originally discovered by, and named after, John W. Huffman, but has subsequently been sold without his permission as an ingredient of synthetic cannabis smoking blends. Similar to the related 2'-methoxy compound JWH-250, the 2'-bromo compound JWH-249, and the 2'-methyl compound JWH-251, JWH-203 has a phenylacetyl group in place of the naphthoyl ring used in most aminoalkylindole cannabinoid compounds, and has the strongest in vitro binding affinity for the cannabinoid receptors of any compound in the phenylacetyl group. (en) |
| rdfs:label | JWH-203 (en) JWH-203 (pl) JWH-203 (ru) |
| owl:sameAs | freebase:JWH-203 yago-res:JWH-203 wikidata:JWH-203 dbpedia-pl:JWH-203 dbpedia-ru:JWH-203 dbpedia-sh:JWH-203 dbpedia-sr:JWH-203 https://global.dbpedia.org/id/4oFW2 |
| prov:wasDerivedFrom | wikipedia-en:JWH-203?oldid=1106367774&ns=0 |
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| foaf:isPrimaryTopicOf | wikipedia-en:JWH-203 |
| is dbo:wikiPageRedirects of | dbr:C21H22ClNO |
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| is foaf:primaryTopic of | wikipedia-en:JWH-203 |
