KCNK9 (original) (raw)
Potassium channel subfamily K member 9 is a protein that in humans is encoded by the KCNK9 gene. This gene encodes K2P9.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This open channel is highly expressed in the cerebellum. It is inhibited by extracellular acidification and arachidonic acid, and strongly inhibited by phorbol 12-myristate 13-acetate. Phorbol 12-myristate 13-acetate is also known as 12-O-tetradecanoylphorbol-13-acetate (TPA). TASK channels are additionally inhibited by hormones and transmitters that signal through GqPCRs. The resulting cellular depolarization is thought to regulate processes such as motor control and aldosterone secretion. Despite early controversy about the exact mechanism underlying this inhibi
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| dbo:abstract | Potassium channel subfamily K member 9 is a protein that in humans is encoded by the KCNK9 gene. This gene encodes K2P9.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This open channel is highly expressed in the cerebellum. It is inhibited by extracellular acidification and arachidonic acid, and strongly inhibited by phorbol 12-myristate 13-acetate. Phorbol 12-myristate 13-acetate is also known as 12-O-tetradecanoylphorbol-13-acetate (TPA). TASK channels are additionally inhibited by hormones and transmitters that signal through GqPCRs. The resulting cellular depolarization is thought to regulate processes such as motor control and aldosterone secretion. Despite early controversy about the exact mechanism underlying this inhibition, the current view is that Diacyl-glycerol, produced by the breakdown of Phosphatidylinositol-4,5-bis-phosphate by Phospholipase Cβ causes channel closure. (en) KCNK9 (англ. Potassium two pore domain channel subfamily K member 9) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 8-ї хромосоми. Довжина поліпептидного ланцюга білка становить 374 амінокислот, а молекулярна маса — 42 264. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Кодований геном білок за функцією належить до іонних каналів. Задіяний у таких біологічних процесах, як транспорт іонів, транспорт, транспорт калію. Білок має сайт для зв'язування з калію. Локалізований у клітинній мембрані, мембрані. (uk) |
| dbo:wikiPageExternalLink | https://escholarship.org/uc/item/9z7112ns |
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| dbo:wikiPageWikiLink | dbr:12-O-Tetradecanoylphorbol-13-acetate dbr:Gene dbr:Arachidonic_acid dbr:Phospholipase_C dbr:Aldosterone dbc:Ion_channels dbr:KCNK3 dbr:Protein dbr:Phosphatidylinositol_4,5-bisphosphate dbr:Tandem_pore_domain_potassium_channel dbr:Diacyl_glycerol |
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| dcterms:subject | dbc:Ion_channels |
| gold:hypernym | dbr:Protein |
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| rdfs:comment | Potassium channel subfamily K member 9 is a protein that in humans is encoded by the KCNK9 gene. This gene encodes K2P9.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This open channel is highly expressed in the cerebellum. It is inhibited by extracellular acidification and arachidonic acid, and strongly inhibited by phorbol 12-myristate 13-acetate. Phorbol 12-myristate 13-acetate is also known as 12-O-tetradecanoylphorbol-13-acetate (TPA). TASK channels are additionally inhibited by hormones and transmitters that signal through GqPCRs. The resulting cellular depolarization is thought to regulate processes such as motor control and aldosterone secretion. Despite early controversy about the exact mechanism underlying this inhibi (en) KCNK9 (англ. Potassium two pore domain channel subfamily K member 9) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 8-ї хромосоми. Довжина поліпептидного ланцюга білка становить 374 амінокислот, а молекулярна маса — 42 264. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин (uk) |
| rdfs:label | KCNK9 (en) KCNK9 (uk) |
| owl:sameAs | freebase:KCNK9 yago-res:KCNK9 wikidata:KCNK9 dbpedia-uk:KCNK9 https://global.dbpedia.org/id/kPUD |
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| is dbo:wikiPageWikiLink of | dbr:FAM135B dbr:Hydroxy-alpha-sanshool dbr:Index_of_biophysics_articles dbr:List_of_human_protein-coding_genes_2 dbr:Potassium_channel dbr:KCNK9_(gene) dbr:Potassium_channel_opener dbr:General_anaesthetic dbr:Cation_channel_superfamily dbr:List_of_OMIM_disorder_codes dbr:Birk-Barel_syndrome dbr:Xenon dbr:Two-pore-domain_potassium_channel dbr:K2p9.1 dbr:TASK-3 |
| is foaf:primaryTopic of | wikipedia-en:KCNK9 |