Kazal domain (original) (raw)

The Kazal domain is an evolutionary conserved protein domain usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. In animals, serine protease inhibitors that act via their Kazal domain are grouped under the MEROPS inhibitor family I1, clan IA.