| dbo:abstract |
Ketanserin ist ein Arzneistoff aus der Gruppe der , der zur Behandlung des Bluthochdrucks (Hypertonie) eingesetzt wird. Ketanserin ist im deutschsprachigen Raum nicht zur Therapie zugelassen. In der experimentellen Pharmakologie findet Ketanserin bei der Untersuchung von Arzneimittelwirkmechanismen Anwendung. Der Wirkstoff wurde 1980 von Janssen Pharmaceutica patentiert. (de) La ketanserina es un antagonista selectivo de los receptores serotoninérgicos 5-HT2 desprovisto de propiedades agonistas. Aunque creada como antagonista de los receptores de 5-HT, bloquea también los receptores adrenérgicos α1. La ketanserina abrió una nueva época en la farmacología de los receptores de 5-hidroxitriptamina (5-HT) y es el prototipo de antagonista de los receptores 5-HT2A a los que bloquea de manera poderosa. Ahora bien, antagoniza con menor potencia en los receptores 5-HT2C y carece de efecto importante sobre los receptores 5-HT3 o 5-HT4 o sobre cualesquiera de los miembros de la familia de receptores de 5-HT1. Es importante señalar que también tiene gran afinidad por los receptores adrenérgicos α y los receptores de histamina H1. (es) Ketanserin (INN, USAN, BAN) (brand name Sufrexal; former developmental code name R41468) is a drug used clinically as an antihypertensive agent and in scientific research to study the serotonin system; specifically, the 5-HT2 receptor family. It was discovered at Janssen Pharmaceutica in 1980. It is not available in the United States. (en) ケタンセリン（Ketanserin）とは5-HT受容体拮抗薬の1つである。海外で高血圧治療薬として用いられているほか、セロトニン系の研究手法、特に5-HT2受容体群の研究に用いられる。5-HT2A受容体を遮断することにより5-ヒドロキシトリプタミン（セロトニン）との結合を抑制し、抗セロトニン作用を示す。1980年に発見された。商品名Sufrexal。開発コードR41468。 (ja) Cetanserina é um fármaco da classe dos anti-hipertensivos e antagonista dos receptores de serotonina 5-HT2. É indicado nas , doença de Raynaud e hipertensão leve e moderada. Antagoniza os receptores de serotonina de forma seletiva. Sua ação foi descoberta por investigadores da em 1980. (pt) |
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| rdfs:comment |
Ketanserin ist ein Arzneistoff aus der Gruppe der , der zur Behandlung des Bluthochdrucks (Hypertonie) eingesetzt wird. Ketanserin ist im deutschsprachigen Raum nicht zur Therapie zugelassen. In der experimentellen Pharmakologie findet Ketanserin bei der Untersuchung von Arzneimittelwirkmechanismen Anwendung. Der Wirkstoff wurde 1980 von Janssen Pharmaceutica patentiert. (de) Ketanserin (INN, USAN, BAN) (brand name Sufrexal; former developmental code name R41468) is a drug used clinically as an antihypertensive agent and in scientific research to study the serotonin system; specifically, the 5-HT2 receptor family. It was discovered at Janssen Pharmaceutica in 1980. It is not available in the United States. (en) ケタンセリン（Ketanserin）とは5-HT受容体拮抗薬の1つである。海外で高血圧治療薬として用いられているほか、セロトニン系の研究手法、特に5-HT2受容体群の研究に用いられる。5-HT2A受容体を遮断することにより5-ヒドロキシトリプタミン（セロトニン）との結合を抑制し、抗セロトニン作用を示す。1980年に発見された。商品名Sufrexal。開発コードR41468。 (ja) Cetanserina é um fármaco da classe dos anti-hipertensivos e antagonista dos receptores de serotonina 5-HT2. É indicado nas , doença de Raynaud e hipertensão leve e moderada. Antagoniza os receptores de serotonina de forma seletiva. Sua ação foi descoberta por investigadores da em 1980. (pt) La ketanserina es un antagonista selectivo de los receptores serotoninérgicos 5-HT2 desprovisto de propiedades agonistas. Aunque creada como antagonista de los receptores de 5-HT, bloquea también los receptores adrenérgicos α1. (es) |
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Ketanserin (de) Ketanserina (es) Ketanserin (en) ケタンセリン (ja) Cetanserina (pt) |
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