Ketazocine (original) (raw)
Ketazocine (INN), also known as ketocyclazocine, is a benzomorphan derivative used in opioid receptor research. Ketazocine, for which the receptor is named, is an exogenous opioid that binds to the κ opioid receptor. Unlike other opioids, substances that only bind to the κ receptor theoretically do not depress the respiratory system. The crystal structure of ketazocine was determined in 1983.
| Property | Value |
|---|---|
| dbo:abstract | Ketazocine (INN), also known as ketocyclazocine, is a benzomorphan derivative used in opioid receptor research. Ketazocine, for which the receptor is named, is an exogenous opioid that binds to the κ opioid receptor. Activation of this receptor is known to cause sleepiness, a decrease in pain sensation and (potentially) dysphoria, paranoia, and hallucinations. It also causes an increase in urine production because it inhibits the release of vasopressin. (Vasopressin is an endogenous substance that assists in regulating fluid and electrolyte balance in the body and decreases the amount of water released into the urine.) Unlike other opioids, substances that only bind to the κ receptor theoretically do not depress the respiratory system. The crystal structure of ketazocine was determined in 1983. (en) La chetazocina (INN), anche nota come chetociclazocina, è un derivato del benzomorfano utilizzato nella ricerca sui recettori oppioidi. La chetociclazocina è un oppioide esogeno che lega i recettori κ-oppioidi. L'attivazione di questo recettore è noto per causare sonnolenza, una riduzione della percezione del dolore e (potenzialmente) anche disforia, paranoia e allucinazioni. È anche causa di un aumento nella produzione urinaria in quanto inibisce il rilascio di vasopressina (è una sostanza endogena che coadiuva la regolazione del bilanciamento elettrolitico e dei fluidi nel corpo umano modulando la quantità di acqua rilasciata con le urine). (it) |
| dbo:casNumber | 36292-69-0 |
| dbo:fdaUniiCode | 6IO4IG518S |
| dbo:kegg | D04649 |
| dbo:pubchem | 3054741 |
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| dbp:pubchem | 3054741 (xsd:integer) |
| dbp:routesOfAdministration | Oral (en) |
| dbp:smiles | O=C2c1c[C@]3C (en) |
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| dcterms:subject | dbc:Ketones dbc:Phenols dbc:Kappa-opioid_receptor_agonists dbc:Benzomorphans dbc:Synthetic_opioids |
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| rdfs:comment | Ketazocine (INN), also known as ketocyclazocine, is a benzomorphan derivative used in opioid receptor research. Ketazocine, for which the receptor is named, is an exogenous opioid that binds to the κ opioid receptor. Unlike other opioids, substances that only bind to the κ receptor theoretically do not depress the respiratory system. The crystal structure of ketazocine was determined in 1983. (en) La chetazocina (INN), anche nota come chetociclazocina, è un derivato del benzomorfano utilizzato nella ricerca sui recettori oppioidi. La chetociclazocina è un oppioide esogeno che lega i recettori κ-oppioidi. (it) |
| rdfs:label | Ketazocine (en) Chetazocina (it) |
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