LCCL domain (original) (raw)
In molecular biology, the LCCL domain is a protein domain which has been named after several well-characterised proteins that were found to contain it, namely Limulus clotting factor C, Cochlin (Coch-5b2) and Lgl1 (CRISPLD2). It is an about 100 amino acids domain whose C-terminal part contains a highly conserved histidine in a conserved motif YxxxSxxCxAAVHxGVI. The LCCL module is thought to be an autonomously folding domain that has been used for the construction of various modular proteins through exon-shuffling. It has been found in various metazoan proteins in association with , C-type lectin domains, , CUB domains, or CAP domains. It has been proposed that the LCCL domain could be involved in lipopolysaccharide (LPS) binding. LCCL exhibits a novel fold.
| Property | Value |
|---|---|
| dbo:abstract | In molecular biology, the LCCL domain is a protein domain which has been named after several well-characterised proteins that were found to contain it, namely Limulus clotting factor C, Cochlin (Coch-5b2) and Lgl1 (CRISPLD2). It is an about 100 amino acids domain whose C-terminal part contains a highly conserved histidine in a conserved motif YxxxSxxCxAAVHxGVI. The LCCL module is thought to be an autonomously folding domain that has been used for the construction of various modular proteins through exon-shuffling. It has been found in various metazoan proteins in association with , C-type lectin domains, , CUB domains, or CAP domains. It has been proposed that the LCCL domain could be involved in lipopolysaccharide (LPS) binding. LCCL exhibits a novel fold. Some proteins known to contain a LCCL domain include Limulus factor C, an LPS endotoxin-sensitive trypsin type serine protease which serves to protect the organism from bacterial infection; vertebrate cochlear protein cochlin or coch-5b2 (Cochlin is probably a secreted protein, mutations affecting the LCCL domain of coch-5b2 cause the deafness disorder DFNA9 in humans); and mammalian late gestation lung protein Lgl1, contains two tandem copies of the LCCL domain. (en) |
| dbo:symbol | LCCL |
| dbo:thumbnail | wiki-commons:Special:FilePath/Protein_COCH_PDB_1jbi.png?width=300 |
| dbo:wikiPageID | 34577796 (xsd:integer) |
| dbo:wikiPageLength | 3647 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 997567242 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Proteins dbr:C-terminal dbr:C-type_lectin_domain dbr:CAP_protein_family dbr:Vertebrate dbr:Limulus_clotting_factor_C dbr:Cochlea dbr:Conserved_sequence dbr:Mammalia dbr:Bacteria dbr:CUB_domain dbr:Lipopolysaccharide dbr:Amino_acid dbr:Binding_(molecular) dbr:Protein_domain dbr:Protein_folding dbr:Protein dbc:Protein_domains dbr:Histidine dbr:Cochlin dbr:CRISPLD2 dbr:Metazoan dbr:Organism dbr:Autonomous dbr:Lung dbr:Exon_shuffling dbr:Trypsin dbr:Gestation dbr:Serine_protease dbr:Protein_fold dbr:Protein_motif dbr:Secreted dbr:Complement_B-type_domain dbr:Discoidin_lectin_domain dbr:Von_Willebrand_type_A_domain |
| dbp:caption | LCCL domain in human Cochlin (en) |
| dbp:cath | 1 (xsd:integer) |
| dbp:interpro | IPR004043 (en) |
| dbp:name | LCCL (en) |
| dbp:pfam | PF03815 (en) |
| dbp:pfamClan | CL0513 (en) |
| dbp:scop | 1 (xsd:integer) |
| dbp:symbol | LCCL (en) |
| dbp:wikiPageUsesTemplate | dbt:Commons_category dbt:Infobox_protein_family dbt:InterPro_content dbt:Reflist dbt:PDB |
| dcterms:subject | dbc:Protein_domains |
| gold:hypernym | dbr:Domain |
| rdf:type | owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 yago:Abstraction100002137 yago:Family108078020 yago:Group100031264 yago:Organization108008335 yago:YagoLegalActor yago:YagoLegalActorGeo yago:YagoPermanentlyLocatedEntity dbo:Protein yago:SocialGroup107950920 yago:Unit108189659 |
| rdfs:comment | In molecular biology, the LCCL domain is a protein domain which has been named after several well-characterised proteins that were found to contain it, namely Limulus clotting factor C, Cochlin (Coch-5b2) and Lgl1 (CRISPLD2). It is an about 100 amino acids domain whose C-terminal part contains a highly conserved histidine in a conserved motif YxxxSxxCxAAVHxGVI. The LCCL module is thought to be an autonomously folding domain that has been used for the construction of various modular proteins through exon-shuffling. It has been found in various metazoan proteins in association with , C-type lectin domains, , CUB domains, or CAP domains. It has been proposed that the LCCL domain could be involved in lipopolysaccharide (LPS) binding. LCCL exhibits a novel fold. (en) |
| rdfs:label | LCCL domain (en) |
| owl:sameAs | freebase:LCCL domain wikidata:LCCL domain https://global.dbpedia.org/id/2L8zH |
| prov:wasDerivedFrom | wikipedia-en:LCCL_domain?oldid=997567242&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Protein_COCH_PDB_1jbi.png |
| foaf:isPrimaryTopicOf | wikipedia-en:LCCL_domain |
| is dbo:wikiPageWikiLink of | dbr:Cysteine-rich_secretory_protein_superfamily dbr:Limulus_clotting_factor_C dbr:Cochlin |
| is foaf:primaryTopic of | wikipedia-en:LCCL_domain |
