LY-503430 is an AMPA receptor positive allosteric modulator developed by Eli Lilly. LY-503430 produces both nootropic and neuroprotective effects, reducing brain damage caused by 6-hydroxydopamine or MPTP and also increasing levels of the neurotrophic factor BDNF in the brain, particularly in the substantia nigra, hippocampus, and striatum. It is orally active and the main application it is currently being developed for is treatment of Parkinson's disease, although it has also been proposed to be useful in the treatment of Alzheimer's disease, depression, and schizophrenia.
| Property |
Value |
| dbo:abstract |
LY-503430 is an AMPA receptor positive allosteric modulator developed by Eli Lilly. LY-503430 produces both nootropic and neuroprotective effects, reducing brain damage caused by 6-hydroxydopamine or MPTP and also increasing levels of the neurotrophic factor BDNF in the brain, particularly in the substantia nigra, hippocampus, and striatum. It is orally active and the main application it is currently being developed for is treatment of Parkinson's disease, although it has also been proposed to be useful in the treatment of Alzheimer's disease, depression, and schizophrenia. (en) |
| dbo:casNumber |
625820-83-9 |
| dbo:fdaUniiCode |
3NKZ7DGF3R |
| dbo:pubchem |
9952446 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/LY503430.svg?width=300 |
| dbo:wikiPageID |
16186586 (xsd:integer) |
| dbo:wikiPageLength |
5014 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1107521769 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:6-hydroxydopamine dbr:Schizophrenia dbr:Depression_(mood) dbc:Experimental_drugs dbc:Organofluorides dbr:Oral_administration dbr:Substantia_nigra dbr:Eli_Lilly_and_Company dbr:MPTP dbr:Positive_allosteric_modulator dbr:BDNF dbc:Benzamides dbr:Alzheimer's_disease dbr:Nootropic dbr:Parkinson's_disease dbr:Hippocampus dbr:AMPA_receptor dbr:AMPA_receptor_positive_allosteric_modulator dbc:AMPA_receptor_positive_allosteric_modulators dbc:Sulfonamides dbc:Eli_Lilly_and_Company_brands dbr:Striatum dbr:Neuroprotective |
| dbp:c |
20 (xsd:integer) |
| dbp:casNumber |
625820 (xsd:integer) |
| dbp:chemspiderid |
8128056 (xsd:integer) |
| dbp:f |
1 (xsd:integer) |
| dbp:h |
25 (xsd:integer) |
| dbp:iupacName |
4 (xsd:integer) |
| dbp:legalUs |
Investigational New Drug (en) |
| dbp:n |
2 (xsd:integer) |
| dbp:o |
3 (xsd:integer) |
| dbp:pubchem |
9952446 (xsd:integer) |
| dbp:routesOfAdministration |
dbr:Oral_administration |
| dbp:s |
1 (xsd:integer) |
| dbp:smiles |
CCSNCCcccc2-cccc1CNC (en) |
| dbp:stdinchi |
1 (xsd:integer) |
| dbp:stdinchikey |
MFJKNXILEXBWNQ-FQEVSTJZSA-N (en) |
| dbp:synonyms |
(LY-503430; -4'-[1-fluoro-1-methyl-2--ethyl]-biphenyl-4-carboxylic acid methylamide) (en) |
| dbp:unii |
3 (xsd:integer) |
| dbp:verifiedfields |
changed (en) |
| dbp:verifiedrevid |
424901917 (xsd:integer) |
| dbp:watchedfields |
changed (en) |
| dbp:width |
150 (xsd:integer) |
| dbp:wikiPageUsesTemplate |
dbt:Drugbox dbt:Ionotropic_glutamate_receptor_modulators dbt:Nervous-system-drug-stub dbt:Reflist dbt:Short_description dbt:Cascite dbt:Chemspidercite dbt:Drugbankcite dbt:Fdacite dbt:Stdinchicite |
| dct:subject |
dbc:Experimental_drugs dbc:Organofluorides dbc:Benzamides dbc:AMPA_receptor_positive_allosteric_modulators dbc:Sulfonamides dbc:Eli_Lilly_and_Company_brands |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:Drug |
| rdfs:comment |
LY-503430 is an AMPA receptor positive allosteric modulator developed by Eli Lilly. LY-503430 produces both nootropic and neuroprotective effects, reducing brain damage caused by 6-hydroxydopamine or MPTP and also increasing levels of the neurotrophic factor BDNF in the brain, particularly in the substantia nigra, hippocampus, and striatum. It is orally active and the main application it is currently being developed for is treatment of Parkinson's disease, although it has also been proposed to be useful in the treatment of Alzheimer's disease, depression, and schizophrenia. (en) |
| rdfs:label |
LY-503430 (en) |
| owl:sameAs |
wikidata:LY-503430 dbpedia-sh:LY-503430 dbpedia-sr:LY-503430 https://global.dbpedia.org/id/4prtn |
| prov:wasDerivedFrom |
wikipedia-en:LY-503430?oldid=1107521769&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/LY503430.svg |
| foaf:isPrimaryTopicOf |
wikipedia-en:LY-503430 |
| is dbo:wikiPageRedirects of |
dbr:C20H25FN2O3S dbr:LY-503,430 dbr:LY503430 |
| is dbo:wikiPageWikiLink of |
dbr:Mibampator dbr:C20H25FN2O3S dbr:LY-503,430 dbr:LY503430 dbr:AMPA_receptor dbr:AMPA_receptor_positive_allosteric_modulator dbr:Pesampator |
| is foaf:primaryTopic of |
wikipedia-en:LY-503430 |
