Levuglandin (original) (raw)
Levuglandins are reactive aldehydes formed by the spontaneous rearrangement of prostaglandin H (PGH). Enantiomerically pure levuglandin (LG) E2 can also be formed through the cyclooxygenase (COX) pathway by a rearrangement of the prostaglandin (PG) endoperoxide PGH 2. They are nonclassic eicosanoids. One species, levuglandin E2, (LGE2), forms neurotoxic adducts with amyloid beta.Levuglandins and isolevuglandins can damage proteins by covalent adduction, thereby interfering with their normal functions. These lipid-derived protein modifications may serve as dosimeters of oxidative injury. Elevated plasma levels of isoLG-protein epitopes are associated with atherosclerosis but are independent of total cholesterol, a classical risk factor.
| Property | Value |
|---|---|
| dbo:abstract | Levuglandins are reactive aldehydes formed by the spontaneous rearrangement of prostaglandin H (PGH). Enantiomerically pure levuglandin (LG) E2 can also be formed through the cyclooxygenase (COX) pathway by a rearrangement of the prostaglandin (PG) endoperoxide PGH 2. They are nonclassic eicosanoids. One species, levuglandin E2, (LGE2), forms neurotoxic adducts with amyloid beta.Levuglandins and isolevuglandins can damage proteins by covalent adduction, thereby interfering with their normal functions. These lipid-derived protein modifications may serve as dosimeters of oxidative injury. Elevated plasma levels of isoLG-protein epitopes are associated with atherosclerosis but are independent of total cholesterol, a classical risk factor. (en) Le levuglandine, o levuloglandine, sono eicosanoidi derivati dall'acido arachidonico. Si formano spontaneamente nell'organismo in seguito al riarrangiamento delle prostaglandine tramite condensazione aldolica. (it) |
| dbo:alternativeName | LGE2 (en) |
| dbo:iupacName | (5Z,8R,9R,10E,12S)-8-acetyl-9-formyl-12- hydroxyheptadeca-5,10-dienoic acid (en) (5Z,8R,9R,10E,12S)-9-acetyl-8-formyl-12- hydroxyheptadeca-5,10-dienoic acid (en) |
| dbo:thumbnail | wiki-commons:Special:FilePath/Levuglandin_D2.svg?width=300 |
| dbo:wikiPageID | 14038137 (xsd:integer) |
| dbo:wikiPageLength | 5589 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1042992987 (xsd:integer) |
| dbo:wikiPageWikiLink | dbc:Eicosanoids dbr:Amyloid_beta dbr:Prostaglandin dbr:Adduct dbr:Aldehyde dbr:Nonclassic_eicosanoid |
| dbp:imagefile | Levuglandin D2.svg (en) Levuglandin E2.svg (en) |
| dbp:iupacname | -9 (xsd:integer) -8 (xsd:integer) |
| dbp:name | Levuglandin D2 (en) Levuglandin E2 (en) |
| dbp:othernames | LGE2 (en) |
| dbp:verifiedfields | changed (en) |
| dbp:verifiedrevid | 367263100 (xsd:integer) |
| dbp:watchedfields | changed (en) |
| dbp:wikiPageUsesTemplate | dbt:Chembox dbt:Chembox_Hazards dbt:Chembox_Identifiers dbt:Chembox_Properties dbt:Cascite dbt:Chemspidercite dbt:Keggcite dbt:Stdinchicite |
| dcterms:subject | dbc:Eicosanoids |
| gold:hypernym | dbr:Aldehydes |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q11173 dbo:ChemicalCompound umbel-rc:ChemicalSubstanceType |
| rdfs:comment | Levuglandins are reactive aldehydes formed by the spontaneous rearrangement of prostaglandin H (PGH). Enantiomerically pure levuglandin (LG) E2 can also be formed through the cyclooxygenase (COX) pathway by a rearrangement of the prostaglandin (PG) endoperoxide PGH 2. They are nonclassic eicosanoids. One species, levuglandin E2, (LGE2), forms neurotoxic adducts with amyloid beta.Levuglandins and isolevuglandins can damage proteins by covalent adduction, thereby interfering with their normal functions. These lipid-derived protein modifications may serve as dosimeters of oxidative injury. Elevated plasma levels of isoLG-protein epitopes are associated with atherosclerosis but are independent of total cholesterol, a classical risk factor. (en) Le levuglandine, o levuloglandine, sono eicosanoidi derivati dall'acido arachidonico. Si formano spontaneamente nell'organismo in seguito al riarrangiamento delle prostaglandine tramite condensazione aldolica. (it) |
| rdfs:label | Levuglandine (it) Levuglandin (en) |
| owl:sameAs | freebase:Levuglandin wikidata:Levuglandin http://azb.dbpedia.org/resource/لووقلاندین dbpedia-fa:Levuglandin dbpedia-it:Levuglandin dbpedia-sh:Levuglandin dbpedia-sr:Levuglandin https://global.dbpedia.org/id/4pv7Y |
| prov:wasDerivedFrom | wikipedia-en:Levuglandin?oldid=1042992987&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Levuglandin_D2.svg wiki-commons:Special:FilePath/Levuglandin_E2.svg |
| foaf:isPrimaryTopicOf | wikipedia-en:Levuglandin |
| foaf:name | Levuglandin D2 (en) Levuglandin E2 (en) |
| is dbo:wikiPageRedirects of | dbr:Levuglandin_D2 dbr:Levuglandin_E2 |
| is dbo:wikiPageWikiLink of | dbr:Nonclassic_eicosanoid dbr:Levuglandin_D2 dbr:Levuglandin_E2 |
| is foaf:primaryTopic of | wikipedia-en:Levuglandin |
