Lobucavir (original) (raw)
Lobucavir (previously known as BMS-180194, Cyclobut-G) is an antiviral drug that shows broad-spectrum activity against herpesviruses, hepatitis B and other hepadnaviruses, HIV/AIDS and cytomegalovirus. It initially demonstrated positive results in human clinical trials against hepatitis B with minimal adverse effects but was discontinued from further development following the discovery of increased risk of cancer associated with long-term use in mice. Although this carcinogenic risk is present in other antiviral drugs, such as zidovudine and ganciclovir that have been approved for clinical use, development was halted by Bristol-Myers Squibb, its manufacturer.
| Property | Value |
|---|---|
| dbo:abstract | Lobucavir (previously known as BMS-180194, Cyclobut-G) is an antiviral drug that shows broad-spectrum activity against herpesviruses, hepatitis B and other hepadnaviruses, HIV/AIDS and cytomegalovirus. It initially demonstrated positive results in human clinical trials against hepatitis B with minimal adverse effects but was discontinued from further development following the discovery of increased risk of cancer associated with long-term use in mice. Although this carcinogenic risk is present in other antiviral drugs, such as zidovudine and ganciclovir that have been approved for clinical use, development was halted by Bristol-Myers Squibb, its manufacturer. (en) |
| dbo:alternativeName | Lobucavir (en) |
| dbo:casNumber | 127759-89-1 |
| dbo:chEMBL | 23550 |
| dbo:drugbank | DB12531 |
| dbo:fdaUniiCode | 8U5PYQ1R2E |
| dbo:kegg | D04757 |
| dbo:pubchem | 135413519 |
| dbo:thumbnail | wiki-commons:Special:FilePath/Lobucavir_structure.png?width=300 |
| dbo:wikiPageID | 63120463 (xsd:integer) |
| dbo:wikiPageLength | 7310 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 991292230 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Primer_(molecular_biology) dbr:Nucleotide dbr:Antiviral_drug dbr:Cytomegalovirus dbr:DNA_polymerase dbr:DNA_replication dbc:Antiviral_drugs dbc:Diols dbc:Purines dbr:Ganciclovir dbr:Zidovudine dbr:Bristol-Myers_Squibb dbr:Carcinogenesis dbr:Reverse_transcriptase dbc:Cyclobutanes dbr:Guanine dbr:HIV/AIDS dbr:Hepatitis_B dbr:Herpes_simplex_virus dbr:Human_betaherpesvirus_5 dbr:Herpesvirus dbr:Hepadnavirus |
| dbp:c | 11 (xsd:integer) |
| dbp:casNumber | 127759 (xsd:integer) |
| dbp:chembl | 23550 (xsd:integer) |
| dbp:chemspiderid | 54782 (xsd:integer) |
| dbp:drugbank | DB12531 (en) |
| dbp:h | 15 (xsd:integer) |
| dbp:iupacName | 2 (xsd:integer) |
| dbp:kegg | D04757 (en) |
| dbp:legalUs | Investigational New Drug (en) |
| dbp:molecularWeight | 265.270000 (xsd:double) |
| dbp:n | 5 (xsd:integer) |
| dbp:o | 3 (xsd:integer) |
| dbp:pubchem | 135413519 (xsd:integer) |
| dbp:smiles | C1[C@@H]CO (en) |
| dbp:stdinchi | 1 (xsd:integer) |
| dbp:stdinchikey | GWFOVSGRNGAGDL-FSDSQADBSA-N (en) |
| dbp:tradename | Lobucavir (en) |
| dbp:unii | 8 (xsd:integer) |
| dbp:wikiPageUsesTemplate | dbt:Antivirals dbt:Drugbox dbt:Reflist dbt:Antiinfective-drug-stub |
| dcterms:subject | dbc:Antiviral_drugs dbc:Diols dbc:Purines dbc:Cyclobutanes |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:Drug |
| rdfs:comment | Lobucavir (previously known as BMS-180194, Cyclobut-G) is an antiviral drug that shows broad-spectrum activity against herpesviruses, hepatitis B and other hepadnaviruses, HIV/AIDS and cytomegalovirus. It initially demonstrated positive results in human clinical trials against hepatitis B with minimal adverse effects but was discontinued from further development following the discovery of increased risk of cancer associated with long-term use in mice. Although this carcinogenic risk is present in other antiviral drugs, such as zidovudine and ganciclovir that have been approved for clinical use, development was halted by Bristol-Myers Squibb, its manufacturer. (en) |
| rdfs:label | Lobucavir (en) |
| owl:sameAs | wikidata:Lobucavir dbpedia-fa:Lobucavir https://global.dbpedia.org/id/2YGzt |
| prov:wasDerivedFrom | wikipedia-en:Lobucavir?oldid=991292230&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Lobucavir_structure.png |
| foaf:isPrimaryTopicOf | wikipedia-en:Lobucavir |
| is dbo:wikiPageWikiLink of | dbr:List_of_drugs:_Lo |
| is foaf:primaryTopic of | wikipedia-en:Lobucavir |
