Lodenafil (original) (raw)
Iodenafil ou carbonato de iodenafil é o princípio ativo do medicamento Helleva®, desenvolvido pelo laboratório farmacêutico brasileiro Cristália, utilizado no tratamento da disfunção erétil masculina. Foi aprovado para consumo no Brasil, pela Anvisa no dia 22 de outubro de 2007.
| Property | Value |
|---|---|
| dbo:abstract | Lodenafil (also known as hydroxyhomosildenafil, trade name Helleva) is a drug belonging to a class of drugs called PDE5 inhibitor, which many other erectile dysfunction drugs such as sildenafil, tadalafil, and vardenafil also belong to. Like udenafil and avanafil it belongs to a new generation of PDE5 inhibitors. Lodenafil is formulated as a prodrug in the form of the carbonate ester dimer, lodenafil carbonate, which breaks down in the body to form two molecules of the active drug lodenafil. This formulation has higher oral bioavailability than the parent drug. It is manufactured by in Brazil and sold there under the brand-name Helleva. It has undergone Phase III clinical trials, but is not yet approved for use in the United States by the U.S. Food and Drug Administration. (en) Iodenafil ou carbonato de iodenafil é o princípio ativo do medicamento Helleva®, desenvolvido pelo laboratório farmacêutico brasileiro Cristália, utilizado no tratamento da disfunção erétil masculina. Foi aprovado para consumo no Brasil, pela Anvisa no dia 22 de outubro de 2007. (pt) |
| dbo:alternativeName | Helleva (en) |
| dbo:casNumber | 398507-55-6 |
| dbo:fdaUniiCode | 29X84F932D |
| dbo:pubchem | 4742795 |
| dbo:thumbnail | wiki-commons:Special:FilePath/Lodenafil.svg?width=300 |
| dbo:wikiPageID | 24362636 (xsd:integer) |
| dbo:wikiPageLength | 4087 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1120101094 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Brazil dbr:Homosildenafil dbr:Udenafil dbr:United_States dbr:Vardenafil dbr:Oral_administration dbr:Sildenafil dbr:Prodrug dbr:Avanafil dbr:U.S._Food_and_Drug_Administration dbr:Carbonate_ester dbr:Dimer_(chemistry) dbc:PDE5_inhibitors dbr:Bioavailability dbr:Tadalafil dbr:PDE5_inhibitor dbr:Cristália_Produtos_Químicos_e_Farmacêuticos dbr:File:Lodenafil_carbonate.svg |
| dbp:c | 23 (xsd:integer) |
| dbp:casNumber | 398507 (xsd:integer) |
| dbp:chemspiderid | 3929995 (xsd:integer) |
| dbp:h | 32 (xsd:integer) |
| dbp:iupacName | 5 (xsd:integer) |
| dbp:legalStatus | Unscheduled (en) |
| dbp:n | 6 (xsd:integer) |
| dbp:o | 5 (xsd:integer) |
| dbp:pregnancyCategory | Not for use in women (en) |
| dbp:pubchem | 4742795 (xsd:integer) |
| dbp:routesOfAdministration | dbr:Oral_administration |
| dbp:s | 1 (xsd:integer) |
| dbp:smiles | CCCc1c2cnC (en) |
| dbp:stdinchi | 1 (xsd:integer) |
| dbp:stdinchikey | NEYKRKVLEWKOBI-UHFFFAOYSA-N (en) |
| dbp:tradename | Helleva (en) |
| dbp:unii | 29 (xsd:integer) |
| dbp:verifiedfields | changed (en) |
| dbp:verifiedrevid | 451225761 (xsd:integer) |
| dbp:watchedfields | changed (en) |
| dbp:width | 250 (xsd:integer) |
| dbp:wikiPageUsesTemplate | dbt:Phosphodiesterase_inhibitors dbt:Drugbox dbt:Genito-urinary-drug-stub dbt:Piperazines dbt:Reflist dbt:Short_description dbt:Cascite dbt:Chemspidercite dbt:Fdacite dbt:Stdinchicite dbt:Sexual_dysfunction_pharmacotherapies |
| dct:subject | dbc:PDE5_inhibitors |
| gold:hypernym | dbr:Drug |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatPDE5Inhibitors yago:Inhibitor114724436 yago:Matter100020827 yago:PhysicalEntity100001930 dbo:Drug yago:Substance100020090 |
| rdfs:comment | Iodenafil ou carbonato de iodenafil é o princípio ativo do medicamento Helleva®, desenvolvido pelo laboratório farmacêutico brasileiro Cristália, utilizado no tratamento da disfunção erétil masculina. Foi aprovado para consumo no Brasil, pela Anvisa no dia 22 de outubro de 2007. (pt) Lodenafil (also known as hydroxyhomosildenafil, trade name Helleva) is a drug belonging to a class of drugs called PDE5 inhibitor, which many other erectile dysfunction drugs such as sildenafil, tadalafil, and vardenafil also belong to. Like udenafil and avanafil it belongs to a new generation of PDE5 inhibitors. Lodenafil is formulated as a prodrug in the form of the carbonate ester dimer, lodenafil carbonate, which breaks down in the body to form two molecules of the active drug lodenafil. This formulation has higher oral bioavailability than the parent drug. (en) |
| rdfs:label | Lodenafil (en) Iodenafil (pt) |
| owl:sameAs | freebase:Lodenafil wikidata:Lodenafil dbpedia-pt:Lodenafil dbpedia-sh:Lodenafil dbpedia-sr:Lodenafil https://global.dbpedia.org/id/4rAcd yago-res:Lodenafil |
| prov:wasDerivedFrom | wikipedia-en:Lodenafil?oldid=1120101094&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Lodenafil.svg wiki-commons:Special:FilePath/Lodenafil_carbonate.svg |
| foaf:isPrimaryTopicOf | wikipedia-en:Lodenafil |
| is dbo:wikiPageRedirects of | dbr:Helleva dbr:Hydroxyhomosildenafil |
| is dbo:wikiPageWikiLink of | dbr:List_of_designer_drugs dbr:Helleva dbr:PDE5_inhibitor dbr:Hydroxyhomosildenafil |
| is foaf:primaryTopic of | wikipedia-en:Lodenafil |
