Lysin (original) (raw)
Een endolysine is een enzym dat in staat is het peptidoglycaan dat teruggevonden wordt in de celwand van bacteriën af te breken. Hierdoor raakt de celwand van de bacterie beschadigd, wat kan leiden tot het lyseren van de bacteriële cel. Bacteriofagen produceren deze lysines om op het einde van hun (lytische) cyclus zichzelf terug vrij te zetten uit de bacteriële cel om zo nieuwe cellen te infecteren.Afhankelijk van het type binding dat deze endolysines breken, spreken we van muramidases, transglycosylases, amidases of endopeptidases.
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dbo:abstract | Endolysine (auch Murein-Hydrolasen) sind hydrolytische Enzyme, die von Bakteriophagen (kurz: Phagen) kodiert werden und von Bakterien während einer Infektion hergestellt werden. Sie werden in der letzten Phase des lytischen Zyklus produziert, um die Zellwand des Bakterienwirts an spezifischen Stellen zu zerschneiden und so die Freisetzung der Phagennachkommen sicherzustellen. Endolysine sind hochspezialisierte Enzyme, die die Zellwände Gram-positiver Bakterien auflösen und daher als Bacteriocine wirken. Endolysine hydrolysieren das Murein in der Peptidoglykanschicht bakterieller Zellwände, weshalb sie unter anderem als mögliche Alternative zur Therapie antibiotikaresistenter Bakterien diskutiert werden. Bisher gibt es nur ein als Medizinprodukt zugelassenes Enzym (in Cremes und Gelen wird das Endolysin Staphefekt eingesetzt), aber noch keine entsprechenden Arzneimittelzulassungen. (de) Lysins, also known as endolysins or murein hydrolases, are hydrolytic enzymes produced by bacteriophages in order to cleave the host's cell wall during the final stage of the lytic cycle. Lysins are highly evolved enzymes that are able to target one of the five bonds in peptidoglycan (murein), the main component of bacterial cell walls, which allows the release of progeny virions from the lysed cell. Cell-wall-containing Archaea are also lysed by specialized pseudomurein-cleaving lysins, while most archaeal viruses employ alternative mechanisms. Similarly, not all bacteriophages synthesize lysins: some small single-stranded DNA and RNA phages produce membrane proteins that activate the host's autolytic mechanisms such as autolysins. Lysins are being used as antibacterial agents due to their high effectiveness and specificity in comparison with antibiotics, which are susceptible to bacterial resistance. (en) Een endolysine is een enzym dat in staat is het peptidoglycaan dat teruggevonden wordt in de celwand van bacteriën af te breken. Hierdoor raakt de celwand van de bacterie beschadigd, wat kan leiden tot het lyseren van de bacteriële cel. Bacteriofagen produceren deze lysines om op het einde van hun (lytische) cyclus zichzelf terug vrij te zetten uit de bacteriële cel om zo nieuwe cellen te infecteren.Afhankelijk van het type binding dat deze endolysines breken, spreken we van muramidases, transglycosylases, amidases of endopeptidases. (nl) |
dbo:ecNumber | 3.2.1.17 |
dbo:thumbnail | wiki-commons:Special:FilePath/Crystal_structure_of_..._peptidoglycan_analogue.jpg?width=300 |
dbo:wikiPageID | 10439768 (xsd:integer) |
dbo:wikiPageLength | 15869 (xsd:nonNegativeInteger) |
dbo:wikiPageRevisionID | 1043176054 (xsd:integer) |
dbo:wikiPageWikiLink | dbr:Bacterial_flora dbr:Endoglycosidase_H dbr:Endopeptidase dbr:Enzybiotics dbr:Mucous_membrane dbr:Lytic_cycle dbc:Viral_enzymes dbr:Cytokine_storm dbr:Virions dbr:Decolonization_(medicine) dbr:Signal_peptide dbc:EC_3.2.1 dbr:Antibiotics dbr:Archaea dbr:Lysozyme dbr:Peptidoglycan dbr:Protein_Data_Bank dbr:Gram-negative dbr:Gram-positive dbr:Cell_wall dbr:Protein_domain dbr:Bacterial_outer_membrane dbr:Bacteriophage dbr:Hydrolase dbr:Atomic_mass_unit dbr:Holin dbr:Autolysin dbr:Autolysis_(biology) dbr:C-terminus dbr:OBPgp279 dbr:Lysibody dbr:N-acetylmuramoyl-L-alanine_amidase dbr:N-terminus dbr:Phage_therapy dbr:N-acetylglucosamine dbr:N-acetylmuramic_acid dbr:Streptococcus_pyogenes dbr:Pseudomurein dbr:Γ-D-glutaminyl-L-lysine_endopeptidase |
dbp:caption | Crystal structure of the modular CPL-1 endolysin from Streptococcus phage Cp-1 complexed with a peptidoglycan analogue. PDB entry . (en) |
dbp:casNumber | 9001 (xsd:integer) |
dbp:ecNumber | 3.200000 (xsd:double) |
dbp:goCode | 3796 (xsd:integer) |
dbp:iubmbEcNumber | 3 (xsd:integer) |
dbp:name | Lysozyme-like phage lysin (en) |
dbp:width | 270 (xsd:integer) |
dbp:wikiPageUsesTemplate | dbt:Distinguish dbt:EC_number dbt:Enzyme dbt:Enzymes dbt:Other_uses dbt:Portal_bar dbt:Reflist dbt:Sugar_hydrolases dbt:PDBe |
dct:subject | dbc:Viral_enzymes dbc:EC_3.2.1 |
gold:hypernym | dbr:Enzymes |
rdf:type | owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8047 yago:Abstraction100002137 yago:Activator114723079 yago:Catalyst114723628 yago:Chemical114806838 yago:Compound114818238 yago:Enzyme114732946 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 dbo:Enzyme yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 yago:WikicatEnzymes |
rdfs:comment | Een endolysine is een enzym dat in staat is het peptidoglycaan dat teruggevonden wordt in de celwand van bacteriën af te breken. Hierdoor raakt de celwand van de bacterie beschadigd, wat kan leiden tot het lyseren van de bacteriële cel. Bacteriofagen produceren deze lysines om op het einde van hun (lytische) cyclus zichzelf terug vrij te zetten uit de bacteriële cel om zo nieuwe cellen te infecteren.Afhankelijk van het type binding dat deze endolysines breken, spreken we van muramidases, transglycosylases, amidases of endopeptidases. (nl) Endolysine (auch Murein-Hydrolasen) sind hydrolytische Enzyme, die von Bakteriophagen (kurz: Phagen) kodiert werden und von Bakterien während einer Infektion hergestellt werden. Sie werden in der letzten Phase des lytischen Zyklus produziert, um die Zellwand des Bakterienwirts an spezifischen Stellen zu zerschneiden und so die Freisetzung der Phagennachkommen sicherzustellen. Endolysine sind hochspezialisierte Enzyme, die die Zellwände Gram-positiver Bakterien auflösen und daher als Bacteriocine wirken. Endolysine hydrolysieren das Murein in der Peptidoglykanschicht bakterieller Zellwände, weshalb sie unter anderem als mögliche Alternative zur Therapie antibiotikaresistenter Bakterien diskutiert werden. Bisher gibt es nur ein als Medizinprodukt zugelassenes Enzym (in Cremes und Gelen wird (de) Lysins, also known as endolysins or murein hydrolases, are hydrolytic enzymes produced by bacteriophages in order to cleave the host's cell wall during the final stage of the lytic cycle. Lysins are highly evolved enzymes that are able to target one of the five bonds in peptidoglycan (murein), the main component of bacterial cell walls, which allows the release of progeny virions from the lysed cell. Cell-wall-containing Archaea are also lysed by specialized pseudomurein-cleaving lysins, while most archaeal viruses employ alternative mechanisms. Similarly, not all bacteriophages synthesize lysins: some small single-stranded DNA and RNA phages produce membrane proteins that activate the host's autolytic mechanisms such as autolysins. (en) |
rdfs:label | Endolysine (de) Lysin (en) Endolysine (nl) |
owl:differentFrom | dbr:Lysine |
owl:sameAs | freebase:Lysin wikidata:Lysin http://bs.dbpedia.org/resource/Lizini dbpedia-de:Lysin dbpedia-gl:Lysin dbpedia-nl:Lysin dbpedia-nn:Lysin http://uz.dbpedia.org/resource/Lizin https://global.dbpedia.org/id/2UufL |
prov:wasDerivedFrom | wikipedia-en:Lysin?oldid=1043176054&ns=0 |
foaf:depiction | wiki-commons:Special:FilePath/Crystal_structure_of_...xed_with_a_peptidoglycan_analogue.jpg |
foaf:isPrimaryTopicOf | wikipedia-en:Lysin |
foaf:name | Lysozyme-like phage lysin (en) |
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