Lysin (original) (raw)

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Een endolysine is een enzym dat in staat is het peptidoglycaan dat teruggevonden wordt in de celwand van bacteriën af te breken. Hierdoor raakt de celwand van de bacterie beschadigd, wat kan leiden tot het lyseren van de bacteriële cel. Bacteriofagen produceren deze lysines om op het einde van hun (lytische) cyclus zichzelf terug vrij te zetten uit de bacteriële cel om zo nieuwe cellen te infecteren.Afhankelijk van het type binding dat deze endolysines breken, spreken we van muramidases, transglycosylases, amidases of endopeptidases.

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dbo:abstract Endolysine (auch Murein-Hydrolasen) sind hydrolytische Enzyme, die von Bakteriophagen (kurz: Phagen) kodiert werden und von Bakterien während einer Infektion hergestellt werden. Sie werden in der letzten Phase des lytischen Zyklus produziert, um die Zellwand des Bakterienwirts an spezifischen Stellen zu zerschneiden und so die Freisetzung der Phagennachkommen sicherzustellen. Endolysine sind hochspezialisierte Enzyme, die die Zellwände Gram-positiver Bakterien auflösen und daher als Bacteriocine wirken. Endolysine hydrolysieren das Murein in der Peptidoglykanschicht bakterieller Zellwände, weshalb sie unter anderem als mögliche Alternative zur Therapie antibiotikaresistenter Bakterien diskutiert werden. Bisher gibt es nur ein als Medizinprodukt zugelassenes Enzym (in Cremes und Gelen wird das Endolysin Staphefekt eingesetzt), aber noch keine entsprechenden Arzneimittelzulassungen. (de) Lysins, also known as endolysins or murein hydrolases, are hydrolytic enzymes produced by bacteriophages in order to cleave the host's cell wall during the final stage of the lytic cycle. Lysins are highly evolved enzymes that are able to target one of the five bonds in peptidoglycan (murein), the main component of bacterial cell walls, which allows the release of progeny virions from the lysed cell. Cell-wall-containing Archaea are also lysed by specialized pseudomurein-cleaving lysins, while most archaeal viruses employ alternative mechanisms. Similarly, not all bacteriophages synthesize lysins: some small single-stranded DNA and RNA phages produce membrane proteins that activate the host's autolytic mechanisms such as autolysins. Lysins are being used as antibacterial agents due to their high effectiveness and specificity in comparison with antibiotics, which are susceptible to bacterial resistance. (en) Een endolysine is een enzym dat in staat is het peptidoglycaan dat teruggevonden wordt in de celwand van bacteriën af te breken. Hierdoor raakt de celwand van de bacterie beschadigd, wat kan leiden tot het lyseren van de bacteriële cel. Bacteriofagen produceren deze lysines om op het einde van hun (lytische) cyclus zichzelf terug vrij te zetten uit de bacteriële cel om zo nieuwe cellen te infecteren.Afhankelijk van het type binding dat deze endolysines breken, spreken we van muramidases, transglycosylases, amidases of endopeptidases. (nl)
dbo:ecNumber 3.2.1.17
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dbp:caption Crystal structure of the modular CPL-1 endolysin from Streptococcus phage Cp-1 complexed with a peptidoglycan analogue. PDB entry . (en)
dbp:casNumber 9001 (xsd:integer)
dbp:ecNumber 3.200000 (xsd:double)
dbp:goCode 3796 (xsd:integer)
dbp:iubmbEcNumber 3 (xsd:integer)
dbp:name Lysozyme-like phage lysin (en)
dbp:width 270 (xsd:integer)
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rdfs:comment Een endolysine is een enzym dat in staat is het peptidoglycaan dat teruggevonden wordt in de celwand van bacteriën af te breken. Hierdoor raakt de celwand van de bacterie beschadigd, wat kan leiden tot het lyseren van de bacteriële cel. Bacteriofagen produceren deze lysines om op het einde van hun (lytische) cyclus zichzelf terug vrij te zetten uit de bacteriële cel om zo nieuwe cellen te infecteren.Afhankelijk van het type binding dat deze endolysines breken, spreken we van muramidases, transglycosylases, amidases of endopeptidases. (nl) Endolysine (auch Murein-Hydrolasen) sind hydrolytische Enzyme, die von Bakteriophagen (kurz: Phagen) kodiert werden und von Bakterien während einer Infektion hergestellt werden. Sie werden in der letzten Phase des lytischen Zyklus produziert, um die Zellwand des Bakterienwirts an spezifischen Stellen zu zerschneiden und so die Freisetzung der Phagennachkommen sicherzustellen. Endolysine sind hochspezialisierte Enzyme, die die Zellwände Gram-positiver Bakterien auflösen und daher als Bacteriocine wirken. Endolysine hydrolysieren das Murein in der Peptidoglykanschicht bakterieller Zellwände, weshalb sie unter anderem als mögliche Alternative zur Therapie antibiotikaresistenter Bakterien diskutiert werden. Bisher gibt es nur ein als Medizinprodukt zugelassenes Enzym (in Cremes und Gelen wird (de) Lysins, also known as endolysins or murein hydrolases, are hydrolytic enzymes produced by bacteriophages in order to cleave the host's cell wall during the final stage of the lytic cycle. Lysins are highly evolved enzymes that are able to target one of the five bonds in peptidoglycan (murein), the main component of bacterial cell walls, which allows the release of progeny virions from the lysed cell. Cell-wall-containing Archaea are also lysed by specialized pseudomurein-cleaving lysins, while most archaeal viruses employ alternative mechanisms. Similarly, not all bacteriophages synthesize lysins: some small single-stranded DNA and RNA phages produce membrane proteins that activate the host's autolytic mechanisms such as autolysins. (en)
rdfs:label Endolysine (de) Lysin (en) Endolysine (nl)
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foaf:name Lysozyme-like phage lysin (en)
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