| dbo:abstract |
In molecular biology the MAPEG (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) family of proteins are a group of membrane associated proteins with highly divergent functions. Included are the 5-lipoxygenase-activating protein (gene FLAP), leukotriene C4 synthase (EC 2.5.1.37), which catalyzes the production of leukotriene C4 (LTC4) from leukotriene A4 (LTA4), and microsomal glutathione S-transferase II (EC 2.5.1.18) (GST-II), which also produces LTC4 from LTA4. Another example is prostaglandin E synthase. This enzyme catalyses the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase, and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity. (en) MAPEG家族（英語：MAPEG family，全称膜相关类花生酸和谷胱甘肽代谢蛋白家族，英語：Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism family）是一类功能高度不同的膜相关蛋白。 (zh) |
| dbo:symbol |
MAPEG |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Protein_LTC4S_PDB_2PNO.png?width=300 |
| dbo:wikiPageID |
14864560 (xsd:integer) |
| dbo:wikiPageLength |
2458 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
995260384 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Prostaglandin_E_synthase dbr:Proteins dbr:MGST3 dbr:Cyclooxygenase dbr:Leukotriene_C4_synthase dbc:Protein_families dbr:PTGES dbr:MGST2 dbr:Arachidonic_acid dbr:Leukotriene_A4 dbr:Leukotriene_C4 dbr:5-lipoxygenase-activating_protein dbr:Glutathione_S-transferase dbc:Protein_domains dbr:LTC4S dbr:MGST1 |
| dbp:caption |
Crystal structure of human leukotriene C4 synthase. (en) |
| dbp:interpro |
IPR001129 (en) |
| dbp:name |
MAPEG family (en) |
| dbp:opmFamily |
178 (xsd:integer) |
| dbp:opmProtein |
4 (xsd:integer) |
| dbp:pdb |
2 (xsd:integer) |
| dbp:pfam |
PF01124 (en) |
| dbp:prosite |
PS01297 (en) |
| dbp:scop |
2 (xsd:integer) |
| dbp:symbol |
MAPEG (en) |
| dbp:wikiPageUsesTemplate |
dbt:EC_number dbt:InterPro_content dbt:Reflist dbt:InterPro dbt:Pfam_box |
| dcterms:subject |
dbc:Protein_families dbc:Protein_domains |
| gold:hypernym |
dbr:Group |
| rdf:type |
owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 dbo:Band dbo:Protein |
| rdfs:comment |
MAPEG家族（英語：MAPEG family，全称膜相关类花生酸和谷胱甘肽代谢蛋白家族，英語：Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism family）是一类功能高度不同的膜相关蛋白。 (zh) In molecular biology the MAPEG (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) family of proteins are a group of membrane associated proteins with highly divergent functions. Included are the 5-lipoxygenase-activating protein (gene FLAP), leukotriene C4 synthase (EC 2.5.1.37), which catalyzes the production of leukotriene C4 (LTC4) from leukotriene A4 (LTA4), and microsomal glutathione S-transferase II (EC 2.5.1.18) (GST-II), which also produces LTC4 from LTA4. (en) |
| rdfs:label |
MAPEG family (en) MAPEG家族 (zh) |
| owl:sameAs |
freebase:MAPEG family wikidata:MAPEG family dbpedia-zh:MAPEG family https://global.dbpedia.org/id/4r93j |
| prov:wasDerivedFrom |
wikipedia-en:MAPEG_family?oldid=995260384&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/Protein_LTC4S_PDB_2PNO.png |
| foaf:isPrimaryTopicOf |
wikipedia-en:MAPEG_family |
| is dbo:wikiPageRedirects of |
dbr:MAPEG dbr:Membrane_Associated_Proteins_in_Eicosanoid_and_Glutathione_metabolism |
| is dbo:wikiPageWikiLink of |
dbr:Prostaglandin_E_synthase dbr:Leukotriene_C4_synthase dbr:Microsomal_glutathione_S-transferase_1 dbr:Glutathione_S-transferase dbr:Transferase dbr:MAPEG dbr:Membrane_Associated_Proteins_in_Eicosanoid_and_Glutathione_metabolism |
| is foaf:primaryTopic of |
wikipedia-en:MAPEG_family |
