MSCRAMM (original) (raw)
MSCRAMM (acronym for "microbial surface components recognizing adhesive matrix molecules") adhesin proteins mediate the initial attachment of bacteria to host tissue, providing a critical step to establish infection. The MSCRAMMs have mainly been studied in Gram positive pathogens and are promising drug targets. The monoclonal antibody tefibazumab targets ClfA and has been tested in a phase II trial.
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| dbo:abstract | Les MSCRAMM (microbial surface components recognizing adhesive matrix molecules : composants de la surface microbienne reconnaissant les molécules adhésives de la matrice en français) sont des protéines de l', assurant la médiation de la fixation initiale des bactéries au tissu hôte, étape essentielle dans l'établissement de l'infection. Les principales sont la protéine A, le facteur d'agglutination A (ClfA), la protéine A liant la fibronectine (FnbpA) de Staphylococcus aureus, SdrG de Staphylococcus epidermidis, la protéine M de Streptococcus pyogenes et la Protéine G streptococcique d'autres espèces de Streptococcus. Tous ces MSCRAMM se lient au fibrinogène, à l'exception de la protéine A qui lie les IgG, mais d'autres cibles pour les MSCRAMM sont connues, comme la fibronectine, ou dans le cas de la protéine M, la région Fc de certains anticorps. Les MSCRAMM ont principalement été étudiés chez les bactéries à Gram positif et constituent des cibles thérapeutiques prometteuses. L'anticorps monoclonal cible la ClfA et a été testé dans un essai de phase II. (fr) MSCRAMM (acronym for "microbial surface components recognizing adhesive matrix molecules") adhesin proteins mediate the initial attachment of bacteria to host tissue, providing a critical step to establish infection. Examples include protein A, clumping factor A (ClfA), fibronectin binding protein A (FnbpA) from Staphylococcus aureus, from Staphylococcus epidermidis, M protein from Streptococcus pyogenes, and protein G in other Streptococcus species. All of these MSCRAMMs bind to fibrinogen except protein A, that binds IgG, but also other targets for MSCRAMMs are known, such as fibronectin. Protein M binds to the Fc region of certain antibodies. The MSCRAMMs have mainly been studied in Gram positive pathogens and are promising drug targets. The monoclonal antibody tefibazumab targets ClfA and has been tested in a phase II trial. Staphylococcus aureusAn example for MSCRAMMs is S. aureus. On its surface, protein A is expressed, which binds to the Fc region of IgG antibodies (the default antibody type, dealing with bacterial and viral infections). This has an antiphagocytic effect, i.e. macrophages cannot "see" these bacteria as easily as if they were correctly opsonised by antigen. Also, S. aureus expresses fibronectin-binding proteins, which promote binding to mucosal cells and tissue matrices. This protein is also referred to as clumping factor. (en) |
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| dbo:wikiPageWikiLink | dbr:Protein_A dbr:Protein_G dbr:Gram_positive dbr:Staphylococcus_epidermidis dbr:Staphylococcus_aureus dbr:Clinical_trial dbr:Clumping_factor_A dbc:Bacterial_proteins dbr:Tefibazumab dbr:Fibronectin_binding_protein_A dbr:Antibodies dbr:M_protein_(Streptococcus) dbr:Immunoglobulin_G dbr:Streptococcus_pyogenes dbr:SdrG |
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| dcterms:subject | dbc:Bacterial_proteins |
| rdf:type | yago:WikicatBacterialProteins yago:Abstraction100002137 yago:Chemical114806838 yago:Compound114818238 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 |
| rdfs:comment | MSCRAMM (acronym for "microbial surface components recognizing adhesive matrix molecules") adhesin proteins mediate the initial attachment of bacteria to host tissue, providing a critical step to establish infection. The MSCRAMMs have mainly been studied in Gram positive pathogens and are promising drug targets. The monoclonal antibody tefibazumab targets ClfA and has been tested in a phase II trial. (en) Les MSCRAMM (microbial surface components recognizing adhesive matrix molecules : composants de la surface microbienne reconnaissant les molécules adhésives de la matrice en français) sont des protéines de l', assurant la médiation de la fixation initiale des bactéries au tissu hôte, étape essentielle dans l'établissement de l'infection. Les MSCRAMM ont principalement été étudiés chez les bactéries à Gram positif et constituent des cibles thérapeutiques prometteuses. L'anticorps monoclonal cible la ClfA et a été testé dans un essai de phase II. (fr) |
| rdfs:label | MSCRAMM (fr) MSCRAMM (en) |
| owl:sameAs | freebase:MSCRAMM yago-res:MSCRAMM wikidata:MSCRAMM dbpedia-fr:MSCRAMM https://global.dbpedia.org/id/4r6DW |
| prov:wasDerivedFrom | wikipedia-en:MSCRAMM?oldid=983493524&ns=0 |
| foaf:isPrimaryTopicOf | wikipedia-en:MSCRAMM |
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