| dbo:abstract |
3-((2-Methyl-4-thiazolyl)ethynyl)pyridine (MTEP) is a research drug that was developed by Merck & Co. as a selective allosteric antagonist of the metabotropic glutamate receptor subtype mGluR5. Identified through structure-activity relationship studies on an older mGluR5 antagonist MPEP, MTEP has subsequently itself acted as a lead compound for newer and even more improved drugs. MTEP is both more potent and more selective than MPEP as a mGluR5 antagonist, and produces similar neuroprotective, antidepressant, analgesic, and anxiolytic effects but with either similar or higher efficacy depending on the test used. MTEP also has similar efficacy to MPEP in reducing the symptoms of morphine withdrawal, and has anti-addictive effects in a variety of animal models, both reducing ethanol self-administration, and also decreasing the addictive effects of nicotine, cocaine and methamphetamine. (en) |
| dbo:casNumber |
329205-68-7 |
| dbo:pubchem |
9794218 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Mtep.png?width=300 |
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| dbp:alt |
Skeletal formula (en) Space-filling model (en) |
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| dbp:image |
MTEP-3D-spacefill.png (en) |
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CC1=NCC#CC2=CN=CC=C2 (en) |
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NRBNGHCYDWUVLC-UHFFFAOYSA-N (en) |
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changed (en) |
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| dcterms:subject |
dbc:Alkyne_derivatives dbc:3-Pyridyl_compounds dbc:Thiazoles dbc:MGlu5_receptor_antagonists |
| gold:hypernym |
dbr:Drug |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:Abstraction100002137 yago:Acetylene114600742 yago:AliphaticCompound114601294 yago:Base114618253 yago:Chemical114806838 yago:Compound114818238 yago:Material114580897 yago:Matter100020827 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Pyridine114692510 yago:Relation100031921 dbo:Drug yago:Substance100019613 yago:WikicatAlkynes yago:WikicatPyridines umbel-rc:DrugProduct |
| rdfs:comment |
3-((2-Methyl-4-thiazolyl)ethynyl)pyridine (MTEP) is a research drug that was developed by Merck & Co. as a selective allosteric antagonist of the metabotropic glutamate receptor subtype mGluR5. Identified through structure-activity relationship studies on an older mGluR5 antagonist MPEP, MTEP has subsequently itself acted as a lead compound for newer and even more improved drugs. (en) |
| rdfs:label |
MTEP (en) |
| owl:sameAs |
freebase:MTEP yago-res:MTEP wikidata:MTEP dbpedia-sh:MTEP dbpedia-sr:MTEP https://global.dbpedia.org/id/MsfM |
| prov:wasDerivedFrom |
wikipedia-en:MTEP?oldid=1122882327&ns=0 |
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wiki-commons:Special:FilePath/MTEP-3D-spacefill.png wiki-commons:Special:FilePath/Mtep.png |
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wikipedia-en:MTEP |
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dbr:3-((2-Methyl-4-thiazolyl)ethynyl)pyridine |
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wikipedia-en:MTEP |
