| dbo:abstract |
McN5652 is a molecule that can be radiolabeled and then used as a radioligand in positron emission tomography (PET) studies. The [11C]-(+)-McN5652 enantiomer binds to the serotonin transporter. The radioligand is used for molecular neuroimaging and for imaging of the lungs. It was developed by Johnson & Johnson's McNeil Laboratories. According to McNeil, McN5652 was among the strongest SRI ever reported at the time of its discovery (sub nM Ki). However, it is not completely 5-HT selective: the racemate has 5-HT=0.68, NA=2.9, and D=36.8nM, whereas (+)-enantiomer has 5-HT=0.39, NA=1.8, and D=23.5 nM. Paroxetine was listed as 5-HT=0.44 nM, NA=20, and DA=460nM in the same paper by the same authors. (en) |
| dbo:alternativeName |
trans-McN-5652 (en) |
| dbo:iupacName |
rel-(6R,10bS)-6-[4-(Methylsulfanyl)phenyl]-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline (en) |
| dbo:thumbnail |
wiki-commons:Special:FilePath/McN5652.svg?width=300 |
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| dbo:wikiPageWikiLink |
dbr:Enantiomer dbr:Johnson_&_Johnson dbr:QSAR dbc:Thioethers dbr:Radioligand dbc:Radiopharmaceuticals dbr:DASB dbc:Neuroimaging dbc:Pyrroloisoquinolines dbr:JNJ-7925476 dbc:Johnson_&_Johnson_brands dbr:Positron_emission_tomography dbr:McNeil_Laboratories dbr:Serotonin_transporter dbr:Neuroimaging |
| dbp:imagefile |
McN5652.svg (en) |
| dbp:imagesize |
200 (xsd:integer) |
| dbp:iupacname |
rel--6-[4-phenyl]-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline (en) |
| dbp:othernames |
trans-McN-5652 (en) |
| dbp:verifiedfields |
changed (en) |
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462100775 (xsd:integer) |
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changed (en) |
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| dct:subject |
dbc:Thioethers dbc:Radiopharmaceuticals dbc:Neuroimaging dbc:Pyrroloisoquinolines dbc:Johnson_&_Johnson_brands |
| gold:hypernym |
dbr:Molecule |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q11173 yago:Agent114778436 yago:CausalAgent100007347 yago:Drug103247620 yago:Matter100020827 yago:Medicine103740161 yago:Pharmaceutical103920989 yago:PhysicalEntity100001930 yago:Radiopharmaceutical104043268 dbo:ChemicalCompound yago:Substance100020090 yago:WikicatRadiopharmaceuticals |
| rdfs:comment |
McN5652 is a molecule that can be radiolabeled and then used as a radioligand in positron emission tomography (PET) studies. The [11C]-(+)-McN5652 enantiomer binds to the serotonin transporter. The radioligand is used for molecular neuroimaging and for imaging of the lungs. (en) |
| rdfs:label |
McN5652 (en) |
| owl:sameAs |
freebase:McN5652 yago-res:McN5652 wikidata:McN5652 http://azb.dbpedia.org/resource/امسیان_۵۶۵۲ dbpedia-fa:McN5652 dbpedia-sh:McN5652 dbpedia-sr:McN5652 https://global.dbpedia.org/id/4rgbU |
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wikipedia-en:McN5652?oldid=1118993988&ns=0 |
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wiki-commons:Special:FilePath/McN5652.svg |
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