Medifoxamine (original) (raw)
Medifoxamin ist ein Arzneistoff, der vor seiner Marktrücknahme zur Behandlung von Depressionen eingesetzt wurde. Es wirkt als Dopaminwiederaufnahmehemmer und als Agonist am 5HT2A und 5HT2C-Rezeptor. Die Merck-Tochter Lipha vertrieb Medifoxamin als Bestandteil eines Arzneimittels unter dem Handelsnamen Cledial. Medifoxamin wurde hauptsächlich in Frankreich eingesetzt. 1999 wurde es vom Markt genommen, da seltene, aber schwere Fälle von Leberschädigungen bekannt wurden.
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| dbo:abstract | Medifoxamin ist ein Arzneistoff, der vor seiner Marktrücknahme zur Behandlung von Depressionen eingesetzt wurde. Es wirkt als Dopaminwiederaufnahmehemmer und als Agonist am 5HT2A und 5HT2C-Rezeptor. Die Merck-Tochter Lipha vertrieb Medifoxamin als Bestandteil eines Arzneimittels unter dem Handelsnamen Cledial. Medifoxamin wurde hauptsächlich in Frankreich eingesetzt. 1999 wurde es vom Markt genommen, da seltene, aber schwere Fälle von Leberschädigungen bekannt wurden. (de) Medifoxamine, previously sold under the brand names Clédial and Gerdaxyl, is an atypical antidepressant with additional anxiolytic properties acting via dopaminergic and serotonergic mechanisms which was formerly marketed in France and Spain, as well as Morocco. The drug was first introduced in France sometime around 1990. It was withdrawn from the market in 1999 (Morocco) and 2000 (France) following incidences of hepatotoxicity. (en) La medifoxamina è un antidepressivo che non appartiene né alla famiglia dei triciclici né a quella degli IMAO. Nel ratto la medifoxamina corregge i disturbi comportamentali che insorgono a seguito di ablazione dei bulbi olfattivi e antagonizza l'ipotermia e la ptosi indotte dalla reserpina.La medifoxamina non modifica l'attività locomotoria ed esplorativa dell'animale e possiede solo un debole effetto anticolinergico.Probabilmente il farmaco attiva il sistema dopaminergico, agendo come un inibitore della ricaptazione della dopamina, ed in misura minore anche quello noradrenergico. Esercita inoltre un'attività di tipo agonistico sui recettori 5-HT2A e sui recettori 5-HT2C. (it) メジホキサミン（INN：medifoxamine、DCF：médifoxamine）とは、N,N-ジメチル-2,2-ジフェノキシエチルアミンの事である。 20世紀の末に、非定型抗精神病薬または抗不安薬として用いられた、薬物の1つである。 (ja) Medifoxamina, anteriormente vendida sob as marcas Clédial e Gerdaxyl, é um antidepressivo atípico com propriedades ansiolíticas que atua por meio de mecanismos dopaminérgicos e serotonérgicos, anteriormente comercializado na França e Espanha, bem como em Marrocos. A droga foi introduzida pela primeira vez na França por volta de 1990. Foi retirado do mercado em 1999 (Marrocos) e 2000 (França) devido a uma sequência de incidentes de hepatotoxicidade. (pt) |
| dbo:alternativeName | Clédial, Gerdaxyl (en) |
| dbo:bioavailability | 21.000000 (xsd:float) |
| dbo:casNumber | 16604-44-7 (picrate) 16604-45-8 (fumarate) 32359-34-5 |
| dbo:fdaUniiCode | KWU7C2A1NT |
| dbo:kegg | D07341 |
| dbo:pubchem | 36109 |
| dbo:thumbnail | wiki-commons:Special:FilePath/Medifoxamine_Structural_Formulae.png?width=300 |
| dbo:wikiPageID | 17052748 (xsd:integer) |
| dbo:wikiPageLength | 12288 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1107676154 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Norepinephrine_reuptake_inhibitor dbr:Pharmacology dbr:Depression_(mood) dbr:Dopamine_reuptake_inhibitor dbr:Dopaminergic dbr:Racemic_mixture dbc:Dimethylamino_compounds dbc:Phenol_ethers dbr:Oral_administration dbr:Clomipramine dbr:Fumarate dbr:Morocco dbc:Hepatotoxins dbr:Anticholinergic dbr:Anxiolytic dbr:Liver dbr:Clinical_trial dbr:Receptor_antagonist dbr:Stimulant dbr:Muscarinic_acetylcholine_receptor dbc:5-HT2C_antagonists dbr:Active_metabolite dbr:Tricyclic_antidepressant dbr:Alpha_blocker dbr:Amitriptyline dbr:5-HT1A_receptor dbr:5-HT1B_receptor dbr:5-HT1D_receptor dbr:5-HT2A_receptor dbr:5-HT2C_receptor dbr:5-HT3_receptor dbc:5-HT2A_antagonists dbc:Antidepressants dbc:Anxiolytics dbr:France dbr:Double-blind dbr:Generic_term dbc:Withdrawn_drugs dbr:Atypical_antidepressant dbc:Serotonin–dopamine_reuptake_inhibitors dbr:Affinity_(pharmacology) dbr:Hepatotoxicity dbr:Maprotiline dbr:Spain dbr:Imipramine dbr:Sedative dbr:Serotonergic dbr:Serotonin_reuptake_inhibitor dbr:Serotonin_transporter dbr:IC50 dbr:Picrate dbr:Drug_tolerability dbr:Serotonin_receptor dbr:First-pass_metabolism dbr:Controlled_study dbr:Α1-adrenergic_receptor dbr:Withdrawn_drug dbr:CRE-10086 dbr:CRE-10357 |
| dbp:atcPrefix | N06 (en) |
| dbp:atcSuffix | AX13 (en) |
| dbp:bioavailability | 21.0 |
| dbp:c | 16 (xsd:integer) |
| dbp:casNumber | 32359 (xsd:integer) |
| dbp:casSupplemental | 16604 (xsd:integer) |
| dbp:chemspiderid | 33212 (xsd:integer) |
| dbp:chirality | dbr:Racemic_mixture |
| dbp:eliminationHalfLife | 14400.0 10080.0 |
| dbp:h | 19 (xsd:integer) |
| dbp:iupacName | N,N-dimethyl-2,2-diphenoxyethanamine (en) |
| dbp:kegg | D07341 (en) |
| dbp:legalStatus | Rx-only (en) |
| dbp:n | 1 (xsd:integer) |
| dbp:o | 2 (xsd:integer) |
| dbp:pubchem | 36109 (xsd:integer) |
| dbp:routesOfAdministration | dbr:Oral_administration |
| dbp:smiles | CNCCOC2=CC=CC=C2 (en) |
| dbp:stdinchi | 1 (xsd:integer) |
| dbp:stdinchikey | QNMGHBMGNRQPNL-UHFFFAOYSA-N (en) |
| dbp:synonyms | Medifoxamine fumarate; N,N-Dimethyl-2,2-diphenoxyethylamine (en) |
| dbp:tradename | Clédial, Gerdaxyl (en) |
| dbp:unii | KWU7C2A1NT (en) |
| dbp:verifiedrevid | 444759950 (xsd:integer) |
| dbp:width | 200 (xsd:integer) |
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| dcterms:subject | dbc:Dimethylamino_compounds dbc:Phenol_ethers dbc:Hepatotoxins dbc:5-HT2C_antagonists dbc:5-HT2A_antagonists dbc:Antidepressants dbc:Anxiolytics dbc:Withdrawn_drugs dbc:Serotonin–dopamine_reuptake_inhibitors |
| gold:hypernym | dbr:Antidepressant |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatAntidepressants yago:WikicatBicyclicAntidepressants yago:WikicatWithdrawnDrugs yago:Agent114778436 yago:Antidepressant102718811 yago:CausalAgent100007347 yago:Drug103247620 yago:Matter100020827 yago:Medicine103740161 yago:PhysicalEntity100001930 dbo:Drug yago:Substance100020090 umbel-rc:DrugProduct |
| rdfs:comment | Medifoxamin ist ein Arzneistoff, der vor seiner Marktrücknahme zur Behandlung von Depressionen eingesetzt wurde. Es wirkt als Dopaminwiederaufnahmehemmer und als Agonist am 5HT2A und 5HT2C-Rezeptor. Die Merck-Tochter Lipha vertrieb Medifoxamin als Bestandteil eines Arzneimittels unter dem Handelsnamen Cledial. Medifoxamin wurde hauptsächlich in Frankreich eingesetzt. 1999 wurde es vom Markt genommen, da seltene, aber schwere Fälle von Leberschädigungen bekannt wurden. (de) Medifoxamine, previously sold under the brand names Clédial and Gerdaxyl, is an atypical antidepressant with additional anxiolytic properties acting via dopaminergic and serotonergic mechanisms which was formerly marketed in France and Spain, as well as Morocco. The drug was first introduced in France sometime around 1990. It was withdrawn from the market in 1999 (Morocco) and 2000 (France) following incidences of hepatotoxicity. (en) La medifoxamina è un antidepressivo che non appartiene né alla famiglia dei triciclici né a quella degli IMAO. Nel ratto la medifoxamina corregge i disturbi comportamentali che insorgono a seguito di ablazione dei bulbi olfattivi e antagonizza l'ipotermia e la ptosi indotte dalla reserpina.La medifoxamina non modifica l'attività locomotoria ed esplorativa dell'animale e possiede solo un debole effetto anticolinergico.Probabilmente il farmaco attiva il sistema dopaminergico, agendo come un inibitore della ricaptazione della dopamina, ed in misura minore anche quello noradrenergico. Esercita inoltre un'attività di tipo agonistico sui recettori 5-HT2A e sui recettori 5-HT2C. (it) メジホキサミン（INN：medifoxamine、DCF：médifoxamine）とは、N,N-ジメチル-2,2-ジフェノキシエチルアミンの事である。 20世紀の末に、非定型抗精神病薬または抗不安薬として用いられた、薬物の1つである。 (ja) Medifoxamina, anteriormente vendida sob as marcas Clédial e Gerdaxyl, é um antidepressivo atípico com propriedades ansiolíticas que atua por meio de mecanismos dopaminérgicos e serotonérgicos, anteriormente comercializado na França e Espanha, bem como em Marrocos. A droga foi introduzida pela primeira vez na França por volta de 1990. Foi retirado do mercado em 1999 (Marrocos) e 2000 (França) devido a uma sequência de incidentes de hepatotoxicidade. (pt) |
| rdfs:label | Medifoxamin (de) Medifoxamina (it) メジホキサミン (ja) Medifoxamine (en) Medifoxamina (pt) |
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| foaf:depiction | wiki-commons:Special:FilePath/Medifoxamine_Structural_Formulae.png |
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