HDMP-28 (original) (raw)

HDMP-28 or methylnaphthidate is a piperidine based stimulant drug, closely related to methylphenidate, but with the benzene ring replaced by naphthalene. It is a potent dopamine reuptake inhibitor, with several times the potency of methylphenidate and a short duration of action, and is a structural isomer of another potent dopamine reuptake inhibitor, N,O-Dimethyl-4-(2-naphthyl)piperidine-3-carboxylate. D.R. = Discrimination Ratio = [3H]DA ÷ [3H]CFT. A low D.R. = addictive, whereas a high D.R. = low propensity for self-administration.