MiR-125 (original) (raw)

MicroRNA-125 (miR-125) is a highly conserved microRNA family consisting of miR-125a and miR-125b. MiR-125 can be found throughout diverse species from nematode to humans. MiR-125 family members are involved in cell differentiation, proliferation and apoptosis as a result of targeting messenger RNAs related to these cellular processes. By affecting these cellular processes, miR-125 can cause promotion or suppression of pathological processes including carcinogenesis, muscle abnormalities, neurological disorders and pathologies of the immune system. Moreover, miR-125 also plays an important role in normal immune functions and was described to affect development and function of immune cells as well as playing role in immunological host defense in response to bacterial and viral infections.